Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0431 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0431 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0431 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0431 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0431 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0431 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0431 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0431 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0431 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0431 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 1000 nM | Displacement of [3H]- DPCPX binding at human Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- SCH-58,261 binding at human Adenosine A2A receptor expressed in CHO cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK-293 cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- MRE 308F20 binding from human Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- DPCPX binding at human Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- SCH-58,261 binding at human Adenosine A2A receptor expressed in CHO cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- DPCPX from human adenosine A2B receptor expressed in HEK-293 cells | ChEMBL. | 12646033 |
Ki (binding) | > 1000 nM | Displacement of [3H]- MRE 308F20 binding from human Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 12646033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.