Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0598 | 1 | 1 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0414 | 0.6761 | 1 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0029 | 0 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0257 | 0.4017 | 0.4017 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Onchocerca volvulus | 0.0184 | 0.2735 | 0.2735 | |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0414 | 0.6761 | 1 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0414 | 0.6761 | 0.6761 |
Onchocerca volvulus | 0.0414 | 0.6761 | 0.6761 | |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0414 | 0.6761 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.2148 | 0.2148 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.3996 | 0.3996 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0414 | 0.6761 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0414 | 0.6761 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0598 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Onchocerca volvulus | 0.0414 | 0.6761 | 0.6761 | |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0414 | 0.6761 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Brugia malayi | Trypsin family protein | 0.0414 | 0.6761 | 0.6761 |
Loa Loa (eye worm) | trypsin family protein | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | hypothetical protein | 0.013 | 0.1781 | 0.1781 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0414 | 0.6761 | 0.6761 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0257 | 0.4017 | 0.4017 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0598 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0414 | 0.6761 | 1 |
Echinococcus granulosus | Mastin | 0.0414 | 0.6761 | 1 |
Onchocerca volvulus | 0.0414 | 0.6761 | 0.6761 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6761 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0267 | 0.419 | 0.419 |
Onchocerca volvulus | 0.0414 | 0.6761 | 0.6761 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0257 | 0.4017 | 0.4017 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Loa Loa (eye worm) | hypothetical protein | 0.0598 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Brugia malayi | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0151 | 0.2148 | 0.3176 |
Onchocerca volvulus | 0.0414 | 0.6761 | 0.6761 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.2148 | 0.2148 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.013 | 0.1781 | 0.2634 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Mycobacterium ulcerans | hypothetical protein | 0.0414 | 0.6761 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0414 | 0.6761 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0414 | 0.6761 | 0.6761 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0414 | 0.6761 | 1 |
Brugia malayi | Trypsin family protein | 0.0414 | 0.6761 | 0.6761 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0598 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0414 | 0.6761 | 0.6761 |
Echinococcus multilocularis | Mastin | 0.0414 | 0.6761 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.013 | 0.1781 | 0.2634 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0029 | 0 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0414 | 0.6761 | 0.6761 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 0.6 | In vitro antimycotic activity of compound against C. albicans was determined as -log MIC90 compound to that of -log MIC90 bifonazole | ChEMBL. | 8632429 |
Ratio (functional) | = 6.8 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MICcompd/MICbifonazole) | ChEMBL. | 16078834 |
Ratio (functional) | = 0.25 | Anticandida activity- (MIC90 compound) / (MIC90 bifonazole) | ChEMBL. | 12061875 |
Ratio (functional) | = 0.6 | In vitro antimycotic activity of compound against C. albicans was determined as -log MIC90 compound to that of -log MIC90 bifonazole | ChEMBL. | 8632429 |
Ratio (functional) | = 6.8 | Ratio of the in vitro minimal inhibitory to that of bifonazole against Candida albicans (MICcompd/MICbifonazole) | ChEMBL. | 16078834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.