Detailed information for compound 24982

Basic information

Technical information
  • TDR Targets ID: 24982
  • Name: [6-(2-dimethylaminoethyloxy)-5-methoxy-2,3-di hydroindol-1-yl]-[4-[2-methyl-4-(5-methyl-1,2 ,4-oxadiazol-3-yl)phenyl]phenyl]methanone
  • MW: 512.599 | Formula: C30H32N4O4
  • H donors: 0 H acceptors: 3 LogP: 5.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2CCN(c2cc1OCCN(C)C)C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C
  • InChi: 1S/C30H32N4O4/c1-19-16-24(29-31-20(2)38-32-29)10-11-25(19)21-6-8-22(9-7-21)30(35)34-13-12-23-17-27(36-5)28(18-26(23)34)37-15-14-33(3)4/h6-11,16-18H,12-15H2,1-5H3
  • InChiKey: AXGKNTNGRRGWAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [6-(2-dimethylaminoethyloxy)-5-methoxy-indolin-1-yl]-[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methanone
  • [6-(2-dimethylaminoethyloxy)-5-methoxy-1-indolinyl]-[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methanone
  • [6-(2-dimethylaminoethoxy)-5-methoxy-2,3-dihydroindol-1-yl]-[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methanone
  • [6-(2-dimethylaminoethoxy)-5-methoxy-indolin-1-yl]-[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methanone
  • [6-(2-dimethylaminoethoxy)-5-methoxy-1-indolinyl]-[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0367 0.4614 0.8186
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 0.1139 0.1215
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.046 0.0816
Schistosoma mansoni neuropeptide receptor 0.001 0.0078 0.0138
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0148 0.0262
Echinococcus granulosus serotonin receptor 0.001 0.0078 0.0138
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 0.1139 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.0509 0.0902
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Brugia malayi Protein kinase domain containing protein 0.0016 0.0146 0.0156
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0509 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0094 0.1139 0.1215
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus g-protein coupled receptor 0.001 0.0078 0.0138
Brugia malayi G protein-coupled receptor 0.001 0.0078 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.1139 0.202
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0509 0.0902
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0078 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0791 0.1403
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0146 0.0259
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0078 0.0138
Brugia malayi ecdysone receptor 0.0044 0.0509 0.0543
Loa Loa (eye worm) steroid hormone receptor 0.0237 0.2952 0.3151
Schistosoma mansoni inositol monophosphatase 0.004 0.046 0.0816
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0703 0.889
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus multilocularis somatostatin receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0037 0.0797
Brugia malayi hypothetical protein 0.0044 0.0509 0.0543
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0094 0.1139 0.202
Schistosoma mansoni netrin receptor unc5 0.0016 0.0146 0.0259
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0367 0.4614 0.4924
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0078 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0094 0.1139 0.1215
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0045 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 0.1139 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Schistosoma mansoni amine GPCR 0.001 0.0078 0.0138
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0037 0.0797
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0146 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Brugia malayi hypothetical protein 0.005 0.0576 0.0615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.1139 0.202
Brugia malayi larval opioid receptor 0.001 0.0078 0.0083
Brugia malayi tailless protein 0.0044 0.0509 0.0543
Loa Loa (eye worm) histone methyltransferase 0.001 0.007 0.0074
Echinococcus multilocularis allatostatin A receptor 0.001 0.0078 0.0138
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0078 0.0138
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0094 0.1139 0.202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0791 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0003 0.0006
Echinococcus multilocularis neuropeptide receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Brugia malayi conserved hypotetical protein 0.0044 0.0509 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0094 0.1139 0.1215
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.046 0.5816
Schistosoma mansoni amine GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Brugia malayi ecdysteroid receptor 0.0094 0.1139 0.1215
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.007 0.0124
Schistosoma mansoni hypothetical protein 0.001 0.0078 0.0138
Schistosoma mansoni nuclear receptor 0.0044 0.0509 0.0902
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0045 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 0.1139 0.1215
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.0509 0.0543
Schistosoma mansoni histamine h1 receptor 0.001 0.0078 0.0138
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.046 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0078 0.0083
Echinococcus multilocularis serotonin receptor 0.001 0.0078 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0094 0.1139 0.1215
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0078 0.0138
Echinococcus granulosus neuropeptide s receptor 0.001 0.0078 0.0138
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0078 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0094 0.1139 0.1215
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.0509 0.0543
Echinococcus granulosus hypothetical protein 0.001 0.0078 0.0138
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0078 0.0138
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0078 0.0138
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0078 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0794 0.1408
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0078 0.0138
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.5636 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0146 0.0156
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0094 0.1139 0.202
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0078 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.1139 0.1215
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0078 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0791 1
Brugia malayi nuclear receptor NHR-88 0.0094 0.1139 0.1215
Schistosoma mansoni amine GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0698 0.8808 0.94
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.046 1
Loa Loa (eye worm) DR-78 0.0044 0.0509 0.0543
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0037 0.0797
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0037 0.0797
Schistosoma mansoni hypothetical protein 0.001 0.0078 0.0138
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.046 0.5
Brugia malayi Inositol-1 0.004 0.046 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Schistosoma mansoni thyroid hormone receptor 0.0094 0.1139 0.202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0791 1
Schistosoma mansoni biogenic amine receptor 0.001 0.0078 0.0138
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0078 0.0138
Schistosoma mansoni opsin-like receptor 0.001 0.0078 0.0138
Echinococcus granulosus fmrfamide receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) inositol-1 0.004 0.046 0.0491
Schistosoma mansoni inositol monophosphatase 0.004 0.046 0.0816
Onchocerca volvulus 0.001 0.0078 0.0078
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.0509 0.0902
Schistosoma mansoni cpg binding protein 0.0033 0.0368 0.0654
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.0509 0.0902
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0078 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0094 0.1139 0.1215
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0078 0.0083
Brugia malayi nuclear hormone receptor 0.0094 0.1139 0.1215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Onchocerca volvulus Bile acid receptor homolog 0.0094 0.1139 0.1139
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0094 0.1139 0.202
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.0509 0.0543
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0078 0.0138
Echinococcus multilocularis sex peptide receptor 0.001 0.0078 0.0138
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0078 0.0138
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0078 0.0138
Brugia malayi photoreceptor-specific nuclear receptor 0.0094 0.1139 0.1215
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0078 0.0138
Schistosoma mansoni neuropeptide receptor 0.001 0.0078 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0576 0.0615
Echinococcus multilocularis serotonin receptor 0.001 0.0078 0.0138
Onchocerca volvulus 0.0044 0.0509 0.0509
Schistosoma mansoni nuclear hormone receptor 0.0094 0.1139 0.202
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0094 0.1139 0.202
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0509 0.0902
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0078 0.0083
Onchocerca volvulus 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni neuropeptide receptor 0.001 0.0078 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0078 0.0138
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0576 0.1022
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0791 0.1403
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0791 0.1403
Echinococcus granulosus death domain containing protein 0.0016 0.0146 0.0259
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 0.1139 0.1215
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0346 0.0369
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0509 0.0509
Echinococcus granulosus dnaJ subfamily B 0.0448 0.5636 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Echinococcus granulosus cpg binding protein 0.0033 0.0368 0.0654
Brugia malayi steroid hormone receptor 0.0237 0.2952 0.3151
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0078 0.0083
Schistosoma mansoni biogenic amine receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0323 0.4047 0.4319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0094 0.1139 0.1215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0094 0.1139 0.1215
Brugia malayi Cytochrome P450 family protein 0.0025 0.0261 0.0278
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0037 0.0797
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0078 0.0138
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0078 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0094 0.1139 0.202
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0509 0.0902
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Brugia malayi AKH receptor 0.001 0.0078 0.0083
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0152 0.188 0.3336
Schistosoma mansoni adenoreceptor 0.001 0.0078 0.0138
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0078 0.0138
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0146 0.0146
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.0509 0.0902
Brugia malayi nuclear hormone receptor 0.0742 0.937 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0078 0.0138
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0078 0.0138
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0078 0.0083
Schistosoma mansoni amine GPCR 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0037 0.0797
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0509 0.0902
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0576 0.0615
Brugia malayi G-protein coupled receptor 0.001 0.0078 0.0083
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0146 0.0259
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0078 0.0138
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0094 0.1139 0.202
Brugia malayi CXXC zinc finger family protein 0.0031 0.0346 0.0369
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0078 0.0138
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0078 0.0083
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0045 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni zinc finger protein 0.0044 0.0509 0.0902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0094 0.1139 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Brugia malayi nuclear receptor RXR 0.005 0.0576 0.0615
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Echinococcus multilocularis FTZ F1 alpha 0.0094 0.1139 0.202
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0078 0.0138
Echinococcus granulosus FTZ F1 alpha 0.0094 0.1139 0.202
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0078 0.0138
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Brugia malayi nuclear receptor NHR-88 0.0044 0.0509 0.0543
Onchocerca volvulus 0.001 0.0078 0.0078
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.046 0.5816
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Brugia malayi hypothetical protein 0.005 0.0576 0.0615
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.046 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0094 0.1139 0.1215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0576 0.0615
Echinococcus multilocularis thyroid hormone receptor alpha 0.0094 0.1139 0.202
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus neuropeptide receptor 0.001 0.0078 0.0138
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0406 0.5135
Trichomonas vaginalis helicase, putative 0.0007 0.0037 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.046 0.5816
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0078 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0078 0.0138
Brugia malayi ORL1-like opioid receptor 0.001 0.0078 0.0083
Onchocerca volvulus 0.001 0.0078 0.0078
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0078 0.0138
Echinococcus granulosus g protein coupled receptor 0.001 0.0078 0.0138
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0078 0.0138
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0094 0.1139 0.202
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0146 0.0259
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.3278 0.3498
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0576 0.1022
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0509 0.0902
Onchocerca volvulus 0.001 0.0078 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0094 0.1139 0.202
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Schistosoma mansoni hypothetical protein 0.001 0.0078 0.0138
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni hypothetical protein 0.0016 0.0146 0.0259
Echinococcus granulosus g protein coupled receptor 0.001 0.0078 0.0138
Brugia malayi neuropeptide F receptor 0.001 0.0078 0.0083
Echinococcus multilocularis fmrfamide receptor 0.001 0.0078 0.0138
Echinococcus granulosus somatostatin receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Echinococcus multilocularis g protein coupled receptor 0.001 0.0078 0.0138
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus g protein coupled receptor 0.001 0.0078 0.0138
Echinococcus multilocularis orexin receptor type 2 0.001 0.0078 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.1139 0.202
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0078 0.0138
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0202 0.251 0.4453
Brugia malayi GnHR receptor homolog 0.001 0.0078 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0037 0.0797
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0509 0.0543
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0158
Echinococcus multilocularis cpg binding protein 0.0033 0.0368 0.0654
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus ecdysone induced protein 78C 0.0094 0.1139 0.202
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.1139 0.202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0037 0.0797
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0146 0.0156
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0742 0.937 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0094 0.1139 0.1139
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Echinococcus granulosus orexin receptor type 2 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0078 0.0138
Echinococcus granulosus inositol monophosphatase 1 0.004 0.046 0.0816
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0094 0.1139 0.202
Onchocerca volvulus 0.0094 0.1139 0.1139
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0045 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0094 0.1139 0.1215
Onchocerca volvulus 0.001 0.0078 0.0078
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0078 0.0138
Schistosoma mansoni nuclear receptor 0.0044 0.0509 0.0902
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0078 0.0138
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0971 0.1722
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0576 0.1022
Loa Loa (eye worm) hypothetical protein 0.005 0.0576 0.0615
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0078 0.0083
Echinococcus multilocularis g protein coupled receptor 0.001 0.0078 0.0138
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.0509 0.0543
Schistosoma mansoni opsin-like receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.005 0.0576 0.0615
Brugia malayi Death domain containing protein 0.0016 0.0146 0.0156
Brugia malayi hypothetical protein 0.0044 0.0509 0.0543
Schistosoma mansoni cpg binding protein 0.0033 0.0368 0.0654
Echinococcus multilocularis g protein coupled receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Onchocerca volvulus 0.001 0.0078 0.0078
Schistosoma mansoni myosin xvIII 0.001 0.0078 0.0138
Schistosoma mansoni biogenic amine receptor 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.046 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0078 0.0138
Schistosoma mansoni hypothetical protein 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Echinococcus granulosus Ankyrin 0.0016 0.0148 0.0262
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.0509 0.0902
Loa Loa (eye worm) hypothetical protein 0.0367 0.4614 0.4924
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0078 0.0138
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0367 0.4614 0.4924
Schistosoma mansoni opsin-like receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0078 0.0083
Echinococcus granulosus allatostatin A receptor 0.001 0.0078 0.0138
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0078 0.0138
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0078 0.0138
Brugia malayi Melatonin receptor type 1A 0.001 0.0078 0.0083
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0078 0.0138
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0078 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0094 0.1139 0.202
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 0.1139 0.202
Echinococcus multilocularis fmrfamide receptor 0.001 0.0078 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0094 0.1139 0.1215
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0791 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0094 0.1139 0.1215
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0078 0.0138
Brugia malayi neuropeptide F receptor 0.001 0.0078 0.0083
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.0509 0.0543
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus sex peptide receptor 0.001 0.0078 0.0138
Schistosoma mansoni coup transcription factor 0.0094 0.1139 0.202
Loa Loa (eye worm) hypothetical protein 0.005 0.0576 0.0615
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.046 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.0202 0.251 0.4453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Echinococcus multilocularis ecdysone induced protein 78C 0.0094 0.1139 0.202
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0078 0.0138
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0509 0.0543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0509 0.0902
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0078 0.0138
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0037 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0094 0.1139 0.1215
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0078 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Onchocerca volvulus 0.001 0.0078 0.0078
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0146 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 0.1139 0.1215
Brugia malayi follicle stimulating hormone receptor 0.0262 0.3278 0.3498
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.0509 0.0543
Echinococcus multilocularis Ankyrin 0.0016 0.0148 0.0262
Schistosoma mansoni hypothetical protein 0.0448 0.5636 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0187 0.2322 0.412
Brugia malayi Steroid receptor seven-up type 2 0.0094 0.1139 0.1215
Schistosoma mansoni cpg binding protein 0.0031 0.0346 0.0613
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0078 0.0138
Onchocerca volvulus 0.0031 0.0346 0.0346
Brugia malayi Serotonin receptor 0.001 0.0078 0.0083
Schistosoma mansoni neuropeptide receptor 0.001 0.0078 0.0138
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.046 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0078 0.0083
Brugia malayi sulfakinin receptor protein 0.001 0.0078 0.0083
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0094 0.1139 0.202
Brugia malayi Dopamine receptor protein 1 0.001 0.0078 0.0083
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0971 0.1722
Echinococcus granulosus neuropeptide receptor 0.001 0.0078 0.0138
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Onchocerca volvulus 0.001 0.0078 0.0078
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0068 0.0073
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.0509 0.0902
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0078 0.0138
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0078 0.0138
Echinococcus multilocularis neuropeptide receptor 0.001 0.0078 0.0138
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0576 0.0615
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0083
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0146 0.0259
Schistosoma mansoni thyroid hormone receptor 0.0094 0.1139 0.202
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Giardia lamblia Hypothetical protein 0.0004 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0078 0.0138
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0078 0.0138
Brugia malayi G-protein coupled receptor 0.001 0.0078 0.0083
Brugia malayi nuclear receptor RXR 0.0044 0.0509 0.0543
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0078 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0576 0.0615
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0078 0.0083
Brugia malayi Dopamine receptor protein 2 0.001 0.0078 0.0083
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0509 0.0509
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.007 0.0124
Loa Loa (eye worm) hypothetical protein 0.0094 0.1139 0.1215
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0045 0.0081
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0004 0 0.5
Brugia malayi Serotonin receptor 0.001 0.0078 0.0083
Brugia malayi putative neuropeptide receptor 0.001 0.0078 0.0083
Schistosoma mansoni steroid hormone receptor ad4bp 0.0094 0.1139 0.202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.046 1
Onchocerca volvulus 0.0044 0.0509 0.0509
Brugia malayi RE15519p 0.001 0.0078 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0094 0.1139 0.202
Brugia malayi Uncoordinated protein 44 0.0016 0.0146 0.0156
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0078 0.0083
Brugia malayi nuclear receptor NHR-67 0.0044 0.0509 0.0543
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0078 0.0138
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0078 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0078 0.0138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0509 0.0543
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0509 0.0902
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.0509 0.0902
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0261 0.0278
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0078 0.0083
Schistosoma mansoni amine GPCR 0.001 0.0078 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0078 0.0138
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0078 0.0138
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0078 0.0138
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0078 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0078 0.0138
Brugia malayi hypothetical protein 0.001 0.0078 0.0083
Onchocerca volvulus 0.001 0.0078 0.0078
Brugia malayi Dopamine receptor 0.001 0.0078 0.0083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0576 0.1022
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0791 0.1403
Onchocerca volvulus 0.001 0.0078 0.0078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0094 0.1139 0.202
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0078 0.0138

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6.5 Binding affinity for human 5-hydroxytryptamine 2A receptor ChEMBL. 9548813
Ki (binding) = 8.3 Binding affinity for human 5-hydroxytryptamine 1D receptor ChEMBL. 9548813
Ki (binding) = 9.3 Binding affinity for human 5-hydroxytryptamine 1B receptor ChEMBL. 9548813
Log Ki (binding) = 6.5 Binding affinity for human 5-hydroxytryptamine 2A receptor ChEMBL. 9548813
Log Ki (binding) = 8.3 Binding affinity for human 5-hydroxytryptamine 1D receptor ChEMBL. 9548813
Log Ki (binding) = 9.3 Binding affinity for human 5-hydroxytryptamine 1B receptor ChEMBL. 9548813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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