Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1201 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1201 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0743 | 0.555 | 0.555 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0743 | 0.555 | 0.555 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0743 | 0.555 | 0.555 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1201 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0172 | 0 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1201 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1201 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1201 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1201 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1201 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1201 | 1 | 1 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1201 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0743 | 0.555 | 0.555 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1201 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1201 | 1 | 0.5 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1201 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1201 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0172 | 0 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1201 | 1 | 0.5 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1201 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1201 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1201 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0377 | 0.199 | 0.199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -3 % | Tested for agonist activity through assays of phosphoinositide (PI) metabolism in slices from rat cerebral cortex | ChEMBL. | 9111297 |
IC50 (binding) | = 32 uM | Inhibition of specific [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor in rat brain membranes | ChEMBL. | 9111297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.