Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii. | ChEMBL. | 10579848 |
IC50 (binding) | = 1.3 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii. | ChEMBL. | 10579848 |
IC50 (binding) | = 3.7 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium avium | ChEMBL. | 10579848 |
IC50 (binding) | = 3.7 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium avium | ChEMBL. | 10579848 |
IC50 (binding) | = 4 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liver | ChEMBL. | 10579848 |
IC50 (binding) | = 4 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liver | ChEMBL. | 10579848 |
IC50 (binding) | = 4.9 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii. | ChEMBL. | 10579848 |
IC50 (binding) | = 4.9 uM | Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii. | ChEMBL. | 10579848 |
Selectivity ratio (binding) | = 0.82 | Ratio of Dihydrofolate reductase inhibitory activity in rat to P. carinii | ChEMBL. | 10579848 |
Selectivity ratio (binding) | = 1.1 | Ratio of Dihydrofolate reductase inhibitory activity in rat to Mycobacterium avium | ChEMBL. | 10579848 |
Selectivity ratio (binding) | = 3.1 | Ratio of Dihydrofolate reductase inhibitory activity in rat to T. gondii | ChEMBL. | 10579848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.