Detailed information for compound 250753

Basic information

Technical information
  • TDR Targets ID: 250753
  • Name: N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2- [2-[[[3-(trifluoromethyl)phenyl]sulfonylamino ]methyl]phenyl]benzamide
  • MW: 581.605 | Formula: C30H26F3N3O4S
  • H donors: 3 H acceptors: 4 LogP: 5.1 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)[C@@H](NC(=O)c1ccccc1c1ccccc1CNS(=O)(=O)c1cccc(c1)C(F)(F)F)Cc1ccccc1
  • InChi: 1S/C30H26F3N3O4S/c31-30(32,33)22-12-8-13-23(18-22)41(39,40)35-19-21-11-4-5-14-24(21)25-15-6-7-16-26(25)29(38)36-27(28(34)37)17-20-9-2-1-3-10-20/h1-16,18,27,35H,17,19H2,(H2,34,37)(H,36,38)/t27-/m0/s1
  • InChiKey: PFHVDWXLOBKESO-MHZLTWQESA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S)-2-amino-1-benzyl-2-oxo-ethyl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide
  • N-[(1S)-2-amino-1-benzyl-2-oxoethyl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide
  • N-[(2S)-1-azanyl-1-oxo-3-phenyl-propan-2-yl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide
  • N-[(1S)-2-amino-1-benzyl-2-keto-ethyl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide
  • N-[(1S)-2-amino-2-oxo-1-(phenylmethyl)ethyl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide
  • N-[(1S)-2-amino-1-(benzyl)-2-keto-ethyl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide
  • N-[(2S)-1-amino-1-oxo-3-phenyl-propan-2-yl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel subfamily A member 5, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel protein Shaker, putative Get druggable targets OG5_127659 All targets in OG5_127659
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis voltage gated potassium channel potassium voltage-gated channel, shaker-related subfamily, member 5 613 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin L 0.0427 0.4493 0.4458
Schistosoma mansoni cathepsin B (C01 family) 0.0153 0.0738 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Schistosoma mansoni cathepsin s 0.0274 0.2397 0.2349
Giardia lamblia Cathepsin L-like protease 0.0153 0.0738 0.5
Echinococcus granulosus cathepsin l1 0.0555 0.6245 0.6222
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0829 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0153 0.0738 0.068
Schistosoma mansoni cathepsin F (C01 family) 0.0555 0.6245 0.6222
Loa Loa (eye worm) hypothetical protein 0.0829 1 1
Echinococcus granulosus cathepsin b 0.0153 0.0738 0.068
Plasmodium vivax vivapain-2 0.0829 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0153 0.0738 0.068
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Schistosoma mansoni cathepsin S (C01 family) 0.0153 0.0738 0.068
Onchocerca volvulus 0.0829 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0829 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0738 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0829 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Trypanosoma cruzi cysteine peptidase, putative 0.0829 1 1
Giardia lamblia Cathepsin L precursor 0.0153 0.0738 0.5
Onchocerca volvulus 0.0555 0.6245 0.5946
Echinococcus multilocularis cathepsin L 0.0153 0.0738 0.0738
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Giardia lamblia Cysteine protease 0.0153 0.0738 0.5
Echinococcus multilocularis cysteine protease 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Brugia malayi Cathepsin L-like precursor 0.0829 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0274 0.2397 0.2349
Giardia lamblia Cathepsin L-like protease 0.0153 0.0738 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0274 0.2397 0.1791
Giardia lamblia Cathepsin L precursor 0.0153 0.0738 0.5
Loa Loa (eye worm) ctsf protein 0.0829 1 1
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Trypanosoma cruzi cysteine protease, putative 0.0427 0.4493 0.4054
Echinococcus multilocularis cathepsin b 0.0153 0.0738 0.0738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0427 0.4493 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0153 0.0738 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0555 0.6245 0.5946
Loa Loa (eye worm) cathepsin B 0.0153 0.0738 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0829 1 1
Toxoplasma gondii cathepsin CPL 0.0829 1 1
Onchocerca volvulus 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0153 0.0738 0.068
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Brugia malayi Cathepsin L-like precursor 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0829 1 1
Echinococcus granulosus cathepsin l1 0.0829 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0427 0.4493 0.4054
Loa Loa (eye worm) hypothetical protein 0.0274 0.2397 0.2349
Onchocerca volvulus 0.0829 1 1
Loa Loa (eye worm) hypothetical protein 0.0555 0.6245 0.6222
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0738 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0427 0.4493 0.4054
Echinococcus granulosus cathepsin b 0.0153 0.0738 0.068
Brugia malayi Cathepsin L-like precursor 0.0829 1 1
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0829 1 1
Entamoeba histolytica cysteine proteinase 2 0.0427 0.4493 0.4054
Plasmodium vivax vivapain-3 0.0427 0.4493 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0153 0.0738 0.068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0427 0.4493 0.4054
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0153 0.0738 0.068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0738 0.068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0829 1 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Giardia lamblia Cysteine protease 0.0153 0.0738 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0555 0.6245 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0427 0.4493 0.4458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0427 0.4493 0.4458
Plasmodium vivax vivapain-2 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0427 0.4493 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0829 1 1
Schistosoma mansoni cathepsin C 0.0153 0.0738 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0829 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0153 0.0738 0.068
Trypanosoma cruzi cysteine proteinase, putative 0.0427 0.4493 0.4054
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Trypanosoma cruzi cysteine proteinase, putative 0.0427 0.4493 0.4054
Brugia malayi cathepsin L-like precursor 0.0555 0.6245 0.6222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0829 1 1
Onchocerca volvulus 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Leishmania major cathepsin L-like protease 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Plasmodium vivax vivapain-1 0.0427 0.4493 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0829 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0555 0.6245 0.5946
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Giardia lamblia Cathepsin L precursor 0.0153 0.0738 0.5
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Echinococcus multilocularis cathepsin b 0.0153 0.0738 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Giardia lamblia Encystation-specific protease 0.0153 0.0738 0.5
Leishmania major cathepsin L-like protease 0.0829 1 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.2397 0.2349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Leishmania major cysteine peptidase A (CPA) 0.0829 1 1
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0738 0.068
Brugia malayi Cathepsin L-like precursor 0.0274 0.2397 0.2349
Echinococcus multilocularis potassium voltage gated channel protein 0.0104 0.0062 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Echinococcus granulosus cathepsin L 0.0153 0.0738 0.068
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Brugia malayi cathepsin B-like cysteine proteinase 0.0153 0.0738 0.068
Brugia malayi Papain family cysteine protease containing protein 0.0427 0.4493 0.4458
Echinococcus granulosus cysteine protease 0.0427 0.4493 0.4458
Leishmania major cathepsin L-like protease 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0829 1 1
Plasmodium vivax unspecified product 0.0427 0.4493 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Onchocerca volvulus 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Leishmania major cathepsin L-like protease 0.0829 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0153 0.0738 0.068
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Onchocerca volvulus 0.0829 1 1
Giardia lamblia Cathepsin L precursor 0.0153 0.0738 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Leishmania major cathepsin L-like protease 0.0829 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0829 1 1
Giardia lamblia Hypothetical protein 0.0153 0.0738 0.5
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Brugia malayi Cathepsin L-like precursor 0.0555 0.6245 0.6222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0427 0.4493 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0274 0.2397 0.2349
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0153 0.0738 0.068
Giardia lamblia Cathepsin L precursor 0.0153 0.0738 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Echinococcus multilocularis cathepsin L 0.0427 0.4493 0.4493
Giardia lamblia Cathepsin B precursor 0.0153 0.0738 0.5
Entamoeba histolytica cysteine proteinase 1, putative 0.0427 0.4493 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0427 0.4493 0.4054
Loa Loa (eye worm) hypothetical protein 0.0274 0.2397 0.2349
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Giardia lamblia Cysteine protease 0.0153 0.0738 0.5
Loa Loa (eye worm) cysteine protease 0.0829 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0829 1 1
Leishmania major cathepsin L-like protease 0.0829 1 1
Brugia malayi Cathepsin L-like precursor 0.0555 0.6245 0.6222
Trypanosoma cruzi cruzipain precursor, putative 0.0829 1 1
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0427 0.4493 0.4458
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0829 1 1
Loa Loa (eye worm) hypothetical protein 0.0555 0.6245 0.6222
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0427 0.4493 0.4054
Leishmania major cathepsin L-like protease 0.0829 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Leishmania major cathepsin L-like protease 0.0829 1 1
Giardia lamblia Cathepsin L precursor 0.0153 0.0738 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0153 0.0738 0.068
Brugia malayi cathepsin F-like cysteine proteinase 0.0153 0.0738 0.068
Loa Loa (eye worm) hypothetical protein 0.0153 0.0738 0.068
Onchocerca volvulus Cathepsin L homolog 0.0829 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0427 0.4493 0.4458
Trypanosoma cruzi cysteine peptidase, putative 0.0829 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0829 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0153 0.0738 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0427 0.4493 0.4054
Onchocerca volvulus 0.0829 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0153 0.0738 0.068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0274 0.2397 0.2349
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Brugia malayi cathepsin L precursor 0.0153 0.0738 0.068
Plasmodium falciparum cysteine proteinase falcipain 1 0.0427 0.4493 0.4054
Brugia malayi Cathepsin L-like precursor 0.0829 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0829 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0274 0.2397 0.1791
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0153 0.0738 0.068
Plasmodium vivax unspecified product 0.0274 0.2397 0.1791
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0153 0.0738 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0829 1 1
Giardia lamblia Cysteine protease 0.0153 0.0738 0.5
Echinococcus multilocularis cysteine protease 0.0829 1 1
Loa Loa (eye worm) hypothetical protein 0.0555 0.6245 0.6222
Entamoeba histolytica cysteine proteinase, putative 0.0427 0.4493 0.4054
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0555 0.6245 0.6222
Schistosoma mansoni cathepsin F (C01 family) 0.0829 1 1
Giardia lamblia Hypothetical protein 0.0153 0.0738 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.0738 0.068
Entamoeba histolytica cysteine protease, putative 0.0427 0.4493 0.4054
Onchocerca volvulus Cathepsin F homolog 0.0829 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0427 0.4493 0.4458
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0153 0.0738 0.5
Loa Loa (eye worm) fibroinase 0.0829 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0555 0.6245 0.5946
Brugia malayi Cathepsin L-like precursor 0.0829 1 1
Brugia malayi fibroinase precursor 0.0153 0.0738 0.068
Onchocerca volvulus Cathepsin L homolog 0.0829 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.8 uM Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes ChEMBL. 12570371
IC50 (binding) = 4.8 uM Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes ChEMBL. 12570371

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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