Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0024 | 0.0379 | 0.0085 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0377 | 0.0346 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0331 | 0.9369 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0367 | 0.0252 |
Plasmodium vivax | adenosine deaminase, putative | 0.0193 | 0.5339 | 0.5699 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0367 | 0.007 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0296 | 0.8355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0199 | 0.0087 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0024 | 0.0379 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0312 | 0.8817 | 0.9411 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0377 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0199 | 0.0087 |
Brugia malayi | adenosine monophosphate deaminase | 0.0331 | 0.9369 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0193 | 0.5339 | 0.6251 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.028 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0377 | 0.0142 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0529 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.028 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0377 | 0.0346 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0199 | 0.0212 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.013 | 0.3484 | 0.3719 |
Schistosoma mansoni | adenosine deaminase | 0.0193 | 0.5339 | 0.5699 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0193 | 0.5339 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.2031 | 0.2168 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0529 | 0.0564 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0331 | 0.9369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1358 | 0.1341 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0819 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5388 | 0.5697 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.013 | 0.3484 | 0.3503 |
Echinococcus multilocularis | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Trypanosoma brucei | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.013 | 0.3484 | 0.3503 |
Loa Loa (eye worm) | inositol-1 | 0.0024 | 0.0379 | 0.0283 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0022 | 0.0305 | 0.0262 |
Loa Loa (eye worm) | pyruvate kinase | 0.0022 | 0.0311 | 0.0209 |
Echinococcus multilocularis | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0193 | 0.5339 | 0.5699 |
Leishmania major | adenine aminohydrolase | 0.0193 | 0.5339 | 0.5551 |
Onchocerca volvulus | 0.0024 | 0.0377 | 0.0073 | |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0039 | 0.0819 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1358 | 0.1341 |
Toxoplasma gondii | AMP deaminase | 0.0331 | 0.9369 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.013 | 0.3484 | 0.3945 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0145 | 0.3914 | 0.7243 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0311 | 0.0209 |
Toxoplasma gondii | mitochondrial inner membrane translocase subunit TIM17, putative | 0.0039 | 0.0819 | 0.0874 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0819 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1358 | 0.1341 |
Chlamydia trachomatis | pyruvate kinase | 0.0022 | 0.0311 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.2031 | 0.2168 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.013 | 0.3484 | 0.3719 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0708 | 0.0439 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.2031 | 0.2168 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0529 | 0.0241 |
Echinococcus multilocularis | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0039 | 0.0819 | 0.0874 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0377 | 0.0073 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0367 | 0.0062 |
Giardia lamblia | DNA repair protein RAD52 | 0.0353 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.013 | 0.3484 | 0.6411 |
Loa Loa (eye worm) | pyruvate kinase | 0.0022 | 0.0311 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0377 | 0.028 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.013 | 0.3484 | 0.3503 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 0.8335 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0377 | 0.0262 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0377 | 0.04 |
Schistosoma mansoni | adenosine deaminase-related | 0.0193 | 0.5339 | 0.5699 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0145 | 0.3914 | 0.7227 |
Schistosoma mansoni | AMP deaminase | 0.0331 | 0.9369 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0022 | 0.0311 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3653 | 0.3822 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0377 | 0.0073 |
Brugia malayi | Adenosylhomocysteinase | 0.013 | 0.3484 | 0.3503 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1358 | 0.1341 |
Echinococcus multilocularis | adenosine deaminase | 0.0193 | 0.5339 | 0.5699 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0024 | 0.0379 | 0.0076 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0193 | 0.5339 | 0.5699 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0377 | 0.0142 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0529 | 0.0564 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.01 | 0.2611 | 0.2523 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0377 | 0.0346 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0039 | 0.0819 | 0.0561 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0367 | 0.007 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0377 | 0.0346 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0024 | 0.0379 | 0.0076 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0529 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.5339 | 0.5644 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0024 | 0.0379 | 0.0076 |
Schistosoma mansoni | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0199 | 0.0212 |
Plasmodium falciparum | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0377 | 0.0073 |
Schistosoma mansoni | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 0.8335 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0193 | 0.5339 | 0.5551 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0199 | 0.0056 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0367 | 0.007 |
Schistosoma mansoni | inositol monophosphatase | 0.0024 | 0.0379 | 0.0405 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0024 | 0.0379 | 0.0076 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0377 | 0.0073 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.2108 | 0.1984 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.013 | 0.3484 | 0.6391 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0377 | 0.0346 |
Entamoeba histolytica | AMP deaminase, putative | 0.0331 | 0.9369 | 0.9361 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0377 | 0.0262 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0022 | 0.0311 | 0.0011 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0145 | 0.3914 | 0.7168 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0199 | 0.0087 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0377 | 0.0073 |
Loa Loa (eye worm) | AMP deaminase | 0.0331 | 0.9369 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0296 | 0.8355 | 0.8355 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0193 | 0.5339 | 0.5284 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.013 | 0.3484 | 0.3719 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0331 | 0.9369 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0529 | 0.0241 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0022 | 0.0311 | 0.0332 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0312 | 0.8817 | 0.9404 |
Schistosoma mansoni | adenosylhomocysteinase | 0.013 | 0.3484 | 0.3719 |
Mycobacterium ulcerans | pyruvate kinase | 0.0022 | 0.0311 | 0.0218 |
Onchocerca volvulus | 0.0136 | 0.3653 | 0.369 | |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.013 | 0.3484 | 0.3407 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0193 | 0.5339 | 1 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Brugia malayi | Inositol-1 | 0.0024 | 0.0379 | 0.0076 |
Plasmodium falciparum | adenosylhomocysteinase | 0.013 | 0.3484 | 0.3719 |
Echinococcus multilocularis | snurportin 1 | 0.0312 | 0.8817 | 0.9411 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0193 | 0.5339 | 0.6251 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.013 | 0.3484 | 0.6315 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0024 | 0.0379 | 0.0405 |
Echinococcus granulosus | AMP deaminase 2 | 0.0331 | 0.9369 | 1 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0136 | 0.3653 | 0.369 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0377 | 0.0346 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0377 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0529 | 0.0445 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0193 | 0.5339 | 0.5284 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0377 | 0.0073 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0193 | 0.5339 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0331 | 0.9369 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0529 | 0.0564 |
Echinococcus granulosus | adenosine deaminase | 0.0193 | 0.5339 | 0.5699 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.013 | 0.3484 | 0.3945 |
Loa Loa (eye worm) | pyruvate kinase | 0.0022 | 0.0311 | 0.0209 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0024 | 0.0379 | 0.0405 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0039 | 0.0819 | 0.0561 |
Leishmania major | hypothetical protein, conserved | 0.0136 | 0.3653 | 0.369 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0367 | 0.0062 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0331 | 0.9369 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0377 | 0.04 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0024 | 0.0379 | 0.0085 |
Echinococcus granulosus | snurportin 1 | 0.0312 | 0.8817 | 0.9411 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0529 | 0.0564 |
Plasmodium falciparum | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0529 | 0.0564 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0296 | 0.8355 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0193 | 0.5339 | 0.5699 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0708 | 0.0439 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0024 | 0.0379 | 0.0265 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0024 | 0.0379 | 0.0405 |
Echinococcus granulosus | adenosylhomocysteinase | 0.013 | 0.3484 | 0.3719 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.013 | 0.3484 | 0.3503 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0041 | 0.0869 | 0.0694 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0193 | 0.5339 | 0.5551 |
Echinococcus granulosus | pyruvate kinase | 0.0022 | 0.0311 | 0.0332 |
Schistosoma mansoni | inositol monophosphatase | 0.0024 | 0.0379 | 0.0405 |
Entamoeba histolytica | AMP deaminase, putative | 0.0331 | 0.9369 | 0.9361 |
Entamoeba histolytica | hypothetical protein | 0.01 | 0.2611 | 0.2523 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0024 | 0.0379 | 0.0085 |
Giardia lamblia | Pyruvate kinase | 0.0022 | 0.0311 | 0.0311 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.013 | 0.3484 | 0.3639 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0331 | 0.9369 | 1 |
Leishmania major | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0331 | 0.9369 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0176 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0199 | 0.0087 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0039 | 0.0819 | 0.0561 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.013 | 0.3484 | 0.3719 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0081 | 0.2031 | 0.2168 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0199 | 0.0087 |
Plasmodium vivax | pyruvate kinase, putative | 0.0022 | 0.0311 | 0.0332 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0377 | 0.0346 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0024 | 0.0379 | 0.0352 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0039 | 0.0819 | 0.0874 |
Trypanosoma brucei | AMP deaminase, putative | 0.0331 | 0.9369 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Binding (functional) | = 91.2 % | Serum protein binding of compound was evaluated using rat serum | ChEMBL. | 14698185 |
MIC (functional) | > 320 ug ml-1 | Intrinsic antibacterial activity against Pseudomonas aeruginosa | ChEMBL. | 14698185 |
MPC4 (functional) | = 1 ug ml-1 | Minimum inhibitory concentration Pseudomonas aeruginosa in presence of LVFX substrate, (100% growth inhibition) | ChEMBL. | 14698185 |
MPC8 (functional) | = 8 ug ml-1 | Minimum inhibitory concentration against Pseudomonas aeruginosa in presence of LVFX substrate, (100% growth inhibition) | ChEMBL. | 14698185 |
MPC8 (functional) | = 16 ug ml-1 | Minimum inhibitory concentration against Pseudomonas aeruginosa in presence of aztreonam substrate and with 0.125% human serum albumin, (100% growth inhibition) | ChEMBL. | 14698185 |
MPC8 (functional) | = 32 ug ml-1 | Minimum inhibitory concentration against Pseudomonas aeruginosa in presence of aztreonam substrate and with out human serum albumin, (100% growth inhibition) | ChEMBL. | 14698185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.