Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | 0.2843 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1816 | 0.524 | 1 |
Brugia malayi | ecdysteroid receptor | 0.1816 | 0.524 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0686 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1816 | 0.524 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.95 | Inhibition of human leukocyte elastase | ChEMBL. | 2299617 |
Log Ki (binding) | = 5.95 | Inhibition of human leukocyte elastase | ChEMBL. | 2299617 |
Log koff (binding) | = -3 | Component deacylation rate constant for interaction with human leukocyte elastase | ChEMBL. | 2299617 |
Log koff (binding) | = -3 s-1 | Component deacylation rate constant for interaction with human leukocyte elastase | ChEMBL. | 2299617 |
Log kOH- (ADMET) | = 1.69 M-1 s-1 | Alkaline hydrolysis rate of the compound | ChEMBL. | 2299617 |
Log kon (binding) | = 2.95 | Component acylation rate constant for interaction with human leukocyte elastase | ChEMBL. | 2299617 |
Log kon (binding) | = 2.95 M-1 s-1 | Component acylation rate constant for interaction with human leukocyte elastase | ChEMBL. | 2299617 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.