Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0058 | 0.4137 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0058 | 0.4137 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0058 | 0.4137 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0058 | 0.4137 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.3203 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.3203 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0058 | 0.4137 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0058 | 0.4137 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0058 | 0.4137 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0058 | 0.4137 | 0.4137 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0029 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0058 | 0.4137 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0058 | 0.4137 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0036 | 0.0996 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0058 | 0.4137 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0029 | 0.0062 | 0.0062 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0058 | 0.4137 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0058 | 0.4137 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0036 | 0.0996 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.4137 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0058 | 0.4137 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0058 | 0.4137 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0058 | 0.4137 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0058 | 0.4137 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0058 | 0.4137 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.02 uM | Inhibitory concentration against HIV-1 wild type Reverse transcriptase(RT) | ChEMBL. | 7490732 |
IC50 (binding) | = 0.02 uM | Inhibitory concentration against HIV-1 wild type Reverse transcriptase(RT) | ChEMBL. | 7490732 |
IC50 (binding) | > 1 uM | Inhibitory activity against HIV-1 Y181C Reverse transcriptase(RT) | ChEMBL. | 7490732 |
IC50 (binding) | > 1 uM | Inhibitory activity against HIV-1 Y181C Reverse transcriptase(RT) | ChEMBL. | 7490732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.