Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0171 | 0.4354 | 0.614 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0639 | 0.0639 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0168 | 0.4262 | 0.4262 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0767 | 0.1553 |
Brugia malayi | hypothetical protein | 0.0144 | 0.3526 | 0.4971 |
Plasmodium vivax | vivapain-2 | 0.0044 | 0.0471 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0044 | 0.0471 | 0.1287 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0471 | 0.0665 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0355 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.003 | 0.002 | 0.0029 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0044 | 0.0471 | 1 |
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0044 | 0.0471 | 0.0471 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0044 | 0.0471 | 0.0471 |
Brugia malayi | RNA binding protein | 0.0144 | 0.3531 | 0.4979 |
Plasmodium vivax | vivapain-2 | 0.0044 | 0.0471 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0767 | 0.0447 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Mycobacterium ulcerans | hypothetical protein | 0.0187 | 0.4845 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0044 | 0.0471 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0144 | 0.3531 | 0.4979 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.0471 | 0.0471 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.0471 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0767 | 0.1553 |
Echinococcus multilocularis | GPCR, family 2 | 0.0054 | 0.0767 | 0.0447 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0044 | 0.0471 | 0.0665 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Onchocerca volvulus | Huntingtin homolog | 0.0144 | 0.3526 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0736 | 0.1037 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3531 | 0.73 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0767 | 0.1553 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.003 | 0.002 | 0.0029 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0044 | 0.0471 | 0.0638 |
Loa Loa (eye worm) | ctsf protein | 0.0044 | 0.0471 | 0.0665 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0471 | 0.0665 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0044 | 0.0471 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0736 | 0.1488 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0171 | 0.4354 | 0.614 |
Echinococcus multilocularis | tar DNA binding protein | 0.0144 | 0.3531 | 0.4621 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0144 | 0.3531 | 0.4979 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0054 | 0.0767 | 0.1056 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.0471 | 0.0938 |
Loa Loa (eye worm) | RNA binding protein | 0.0144 | 0.3531 | 0.4979 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0044 | 0.0471 | 0.1287 |
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0355 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0767 | 0.1056 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0736 | 0.1488 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3526 | 0.4971 |
Echinococcus granulosus | cathepsin l1 | 0.0044 | 0.0471 | 0.0638 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0864 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0044 | 0.0471 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0054 | 0.0767 | 0.1056 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0044 | 0.0471 | 0.0665 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0044 | 0.0471 | 0.5456 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.005 | 0.0639 | 0.0639 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.0471 | 0.0471 |
Echinococcus granulosus | tar DNA binding protein | 0.0144 | 0.3531 | 0.4964 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0117 | 0.2694 | 0.3799 |
Loa Loa (eye worm) | TAR-binding protein | 0.0144 | 0.3531 | 0.4979 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3531 | 0.73 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0044 | 0.0471 | 0.0638 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3531 | 0.73 |
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.002 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0044 | 0.0471 | 0.0938 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.0471 | 0.0471 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0168 | 0.4262 | 0.4262 |
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0044 | 0.0471 | 0.0471 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.026 | 0.7092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.7092 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.026 | 0.7092 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0187 | 0.4845 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.002 | 0.0029 |
Onchocerca volvulus | 0.0044 | 0.0471 | 0.1287 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.4829 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0639 | 0.0639 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0471 | 0.0665 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0054 | 0.0767 | 0.1082 |
Loa Loa (eye worm) | cysteine protease | 0.0044 | 0.0471 | 0.0665 |
Onchocerca volvulus | Cathepsin F homolog | 0.0044 | 0.0471 | 0.1287 |
Onchocerca volvulus | Huntingtin homolog | 0.0144 | 0.3526 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Leishmania major | cathepsin L-like protease | 0.0044 | 0.0471 | 0.0471 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0168 | 0.4262 | 0.4262 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0054 | 0.0767 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3526 | 0.4971 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.2694 | 0.3799 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0639 | 0.0639 |
Brugia malayi | Cathepsin L-like precursor | 0.003 | 0.002 | 0.0029 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.003 | 0.002 | 0.002 |
Echinococcus granulosus | geminin | 0.0186 | 0.4829 | 0.68 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0471 | 0.0665 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0044 | 0.0471 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.002 | 0.0029 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0061 | 0.0974 | 0.0974 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0767 | 0.1553 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0054 | 0.0767 | 0.1082 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.2694 | 0.556 |
Brugia malayi | hypothetical protein | 0.026 | 0.7092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.002 | 0.0029 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0054 | 0.0767 | 0.0447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3531 | 0.73 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0767 | 0.1082 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.4829 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.4354 | 0.614 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0044 | 0.0471 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0044 | 0.0471 | 0.0471 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0044 | 0.0471 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0471 | 0.0665 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0171 | 0.4354 | 0.614 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0044 | 0.0471 | 0.0665 |
Brugia malayi | TAR-binding protein | 0.0144 | 0.3531 | 0.4979 |
Onchocerca volvulus | 0.0053 | 0.0736 | 0.2041 | |
Echinococcus multilocularis | geminin | 0.0186 | 0.4829 | 0.6582 |
Brugia malayi | Cathepsin L-like precursor | 0.0044 | 0.0471 | 0.0665 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0355 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0144 | 0.3531 | 0.73 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0471 | 0.0665 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 28 mg kg-1 | Analgesic activity for inflamed rat-paw reversal of abnormal (three legged) gait expressed as ED50 (po). | ChEMBL. | 7241504 |
ED50 (functional) | = 29 mg kg-1 | Analgesic activity was measured using mouse anti-writhing method expressed as ED50 (po) | ChEMBL. | 7241504 |
ED50 (functional) | = 50 mg kg-1 | Analgesic activity was measured using inflamed rat paw pressure threshold method expressed as ED50 (po) | ChEMBL. | 7241504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.