Detailed information for compound 251496

Basic information

Technical information
  • TDR Targets ID: 251496
  • Name: benzyl N-[[3-methyl-2-[2-methyl-6-(2-pyridin- 2-ylethylcarbamoyl)phenyl]phenyl]methyl]carba mate
  • MW: 493.596 | Formula: C31H31N3O3
  • H donors: 2 H acceptors: 3 LogP: 5.49 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1cccc(c1c1c(C)cccc1C(=O)NCCc1ccccn1)C)OCc1ccccc1
  • InChi: 1S/C31H31N3O3/c1-22-10-8-14-25(20-34-31(36)37-21-24-12-4-3-5-13-24)28(22)29-23(2)11-9-16-27(29)30(35)33-19-17-26-15-6-7-18-32-26/h3-16,18H,17,19-21H2,1-2H3,(H,33,35)(H,34,36)
  • InChiKey: FYIDUMMKLNXSFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl N-[[3-methyl-2-[2-methyl-6-[2-(2-pyridyl)ethylcarbamoyl]phenyl]phenyl]methyl]carbamate
  • N-[[3-methyl-2-[2-methyl-6-[oxo-[2-(2-pyridyl)ethylamino]methyl]phenyl]phenyl]methyl]carbamic acid benzyl ester
  • phenylmethyl N-[[3-methyl-2-[2-methyl-6-(2-pyridin-2-ylethylcarbamoyl)phenyl]phenyl]methyl]carbamate
  • N-[3-methyl-2-[2-methyl-6-[2-(2-pyridyl)ethylcarbamoyl]phenyl]benzyl]carbamic acid benzyl ester
  • phenylmethyl N-[[3-methyl-2-[2-methyl-6-[2-(2-pyridyl)ethylcarbamoyl]phenyl]phenyl]methyl]carbamate
  • N-[[3-methyl-2-[2-methyl-6-[oxo-[2-(2-pyridyl)ethylamino]methyl]phenyl]phenyl]methyl]carbamic acid phenylmethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel protein Shaker, putative Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel subfamily A member 5, putative Get druggable targets OG5_127659 All targets in OG5_127659
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit Get druggable targets OG5_127659 All targets in OG5_127659
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis voltage gated potassium channel potassium voltage-gated channel, shaker-related subfamily, member 5 613 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0021 0.0279 0.0405
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.2759 0.2759
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0809 0.1173
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0581 0.2104
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.2759 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0338 0.0338
Echinococcus multilocularis potassium voltage gated channel protein 0.0104 0.2651 0.2651
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0809 0.0809
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0809 0.2194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0144 0.0144
Trichomonas vaginalis esterase, putative 0.004 0.0809 0.2194
Mycobacterium tuberculosis Conserved protein 0.004 0.0809 0.1157
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0809 0.1157
Brugia malayi beta-lactamase family protein 0.004 0.0809 0.1173
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1417 0.1417
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.0854
Leishmania major cytochrome p450-like protein 0.0021 0.0279 0.1012
Echinococcus granulosus potassium voltage gated channel protein 0.0104 0.2651 0.2651
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.2759 1
Mycobacterium ulcerans beta-lactamase 0.004 0.0809 0.571
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0261 0.0946
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0808 0.0853
Echinococcus multilocularis tumor protein p63 0.0359 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0261 0.0946
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.2759 0.2759
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0809 0.2194
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.2408
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1119 0.1182
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0839 0.304
Loa Loa (eye worm) hypothetical protein 0.0104 0.2651 0.2799
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0338 0.1225
Entamoeba histolytica hypothetical protein 0.004 0.0808 0.9472
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.0308
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0809 0.571
Schistosoma mansoni hypothetical protein 0.0036 0.0704 0.0744
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0279 0.0295
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0809 0.2932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1119 0.1182
Loa Loa (eye worm) inositol-1 0.0041 0.0839 0.0886
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0144 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1119 0.1119
Mycobacterium leprae conserved hypothetical protein 0.004 0.0809 1
Leishmania major hypothetical protein, conserved 0.004 0.0809 0.2932
Mycobacterium ulcerans hypothetical protein 0.004 0.0809 0.571
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.0152
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0839 0.0839
Echinococcus multilocularis GPCR, family 2 0.0017 0.0144 0.0144
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0809 0.0809
Schistosoma mansoni ap endonuclease 0.0021 0.0261 0.0276
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0104 0.2651 0.3843
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.2759 1
Echinococcus multilocularis snurportin 1 0.034 0.9471 0.9471
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0809 0.1157
Brugia malayi Cytochrome P450 family protein 0.0021 0.0279 0.0405
Schistosoma mansoni importin beta-1 0.0032 0.0581 0.0613
Brugia malayi RNA, U transporter 1 0.0091 0.2275 0.3298
Trypanosoma brucei protein kinase, putative 0.0107 0.2759 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.6824 0.7206
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0809 0.1157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0809 0.0854
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0704 0.1021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0808 0.0808
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.2759 1
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0839 0.0839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1119 0.1182
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0839 0.5919
Onchocerca volvulus 0.0051 0.1137 0.8976
Mycobacterium tuberculosis Conserved protein 0.004 0.0809 0.1157
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.2759 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.049
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0338 0.1225
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0407 0.0584
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0338 0.1225
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.252 0.252
Toxoplasma gondii exonuclease III APE 0.0021 0.0261 0.0946
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1119 0.1119
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0809 0.2932
Trichomonas vaginalis ran, putative 0.0023 0.0338 0.0308
Schistosoma mansoni hypothetical protein 0.034 0.9471 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1137 0.1649
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0338 0.0357
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0581 0.0581
Entamoeba histolytica Ran family GTPase 0.0023 0.0338 0.1332
Mycobacterium tuberculosis Conserved protein 0.004 0.0809 0.1157
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0809 0.2194
Onchocerca volvulus 0.0052 0.1175 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.2759 1
Brugia malayi follicle stimulating hormone receptor 0.0248 0.6824 0.9895
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0407 0.0584
Brugia malayi beta-lactamase 0.004 0.0809 0.1173
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0261 0.0946
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0839 0.2313
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.2759 0.2913
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0279 0.0295
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0581 0.2104
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.2759 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0144 0.0209
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1299 0.1371
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0261 0.1842
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1187 0.1721
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.6992 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0839 0.2313
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0839 0.304
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0279 0.1012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0809 0.1157
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0261 0.0373
Brugia malayi Importin beta-1 subunit 0.0032 0.0581 0.0842
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.2759 1
Schistosoma mansoni ran 0.0023 0.0338 0.0357
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0809 0.571
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.0854
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.0854
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.2759 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0261 0.0261
Brugia malayi Cytochrome P450 family protein 0.0033 0.0608 0.0882
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0407 0.1474
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0279 0.1012
Schistosoma mansoni inositol monophosphatase 0.0041 0.0839 0.0886
Echinococcus granulosus GPCR family 2 0.0017 0.0144 0.0144
Brugia malayi beta-lactamase family protein 0.004 0.0809 0.1173
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0808 0.0808
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0715 0.1023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0144 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0809 0.2194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0809 0.0854
Schistosoma mansoni ran 0.0023 0.0338 0.0357
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0839 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0338 0.1225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1119 0.1182
Leishmania major importin beta-1 subunit, putative 0.0026 0.0407 0.1474
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.0854
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0104 0.2651 0.2651
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0809 0.1157
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0839 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0809 0.1157
Plasmodium vivax hypothetical protein, conserved 0.004 0.0809 1
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.2651 0.2799
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.1175 0.1241
Leishmania major GTP-binding protein, putative 0.0023 0.0338 0.1225
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0261 0.0276
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1187 0.1253
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0839 0.304
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0809 0.2194
Loa Loa (eye worm) hypothetical protein 0.0032 0.0581 0.0613
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1417 0.1417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1119 0.1119
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0809 0.0854
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.1417 0.5136
Schistosoma mansoni survival motor neuron protein 0.0051 0.1137 0.1201
Mycobacterium ulcerans lipase LipD 0.004 0.0809 0.571
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0839 0.304
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0839 0.304
Entamoeba histolytica hypothetical protein 0.004 0.0808 0.9472
Loa Loa (eye worm) hypothetical protein 0.0251 0.6897 0.7282
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.0152
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.9471 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.1417 0.1496
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.1417 0.2054
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0261 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0581 0.2104
Plasmodium falciparum importin beta, putative 0.0032 0.0581 1
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0809 0.1157
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.2759 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.0854
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.6897 0.6897
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0715 0.8842
Schistosoma mansoni ap endonuclease 0.0021 0.0261 0.0276
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0261 0.0946
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.2759 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.2759 0.2759
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0407 0.0584
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.0152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0144 0.0144
Toxoplasma gondii ABC1 family protein 0.004 0.0809 0.2932
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1417 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0581 0.5831
Loa Loa (eye worm) hypothetical protein 0.0017 0.0144 0.0152
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1187 0.1721
Echinococcus granulosus importin subunit beta 1 0.0032 0.0581 0.0581
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0279 0.0295
Brugia malayi MAP kinase sur-1 0.0107 0.2759 0.4
Mycobacterium leprae Probable lipase LipE 0.004 0.0809 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0809 0.0854
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.2759 1
Brugia malayi Inositol-1 0.0041 0.0839 0.1216
Schistosoma mansoni hypothetical protein 0.004 0.0808 0.0853
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0839 0.2313
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.6897 0.6897
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0279 0.1012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1119 0.1623
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0144 0.0209
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.2651 0.2799
Schistosoma mansoni hypothetical protein 0.0051 0.1137 0.1201
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.2759 1
Brugia malayi hypothetical protein 0.0251 0.6897 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1187 0.1253
Entamoeba histolytica hypothetical protein 0.0026 0.0407 0.2523
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0261 0.0378
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1417 1
Entamoeba histolytica hypothetical protein 0.004 0.0808 0.9472
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0608 0.0642
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.0152
Loa Loa (eye worm) hypothetical protein 0.0052 0.1175 0.1241
Echinococcus granulosus snurportin 1 0.034 0.9471 0.9471
Loa Loa (eye worm) hypothetical protein 0.004 0.0809 0.0854
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0338 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.2759 0.2913
Entamoeba histolytica hypothetical protein 0.004 0.0808 0.9472
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0261 0.0261
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0279 0.197
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0809 0.2932
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1417 0.2027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1119 0.1119
Loa Loa (eye worm) hypothetical protein 0.0036 0.0704 0.0744
Schistosoma mansoni inositol monophosphatase 0.0041 0.0839 0.0886
Brugia malayi hypothetical protein 0.004 0.0808 0.1172
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.2759 0.2759
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0338 0.1404
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0144 0.0152

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.7 uM Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes ChEMBL. 12570371
IC50 (binding) = 0.7 uM Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes ChEMBL. 12570371
IC50 (binding) = 1.7 uM Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes ChEMBL. 12570371
IC50 (binding) = 1.7 uM Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes ChEMBL. 12570371

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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