Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0306 | 0.4905 | 0.4905 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0343 | 0.5734 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0343 | 0.5734 | 0.5734 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0343 | 0.5734 | 1 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0202 | 0.2585 | 0.7148 |
Plasmodium falciparum | cyclin | 0.0248 | 0.3617 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0206 | 0.2683 | 0.4556 |
Toxoplasma gondii | hypothetical protein | 0.0188 | 0.2279 | 0.8755 |
Toxoplasma gondii | AGC kinase | 0.0202 | 0.2585 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0285 | 0.4437 | 0.7687 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Schistosoma mansoni | cyclin B | 0.0248 | 0.3617 | 0.6222 |
Echinococcus granulosus | cyclins | 0.0248 | 0.3617 | 0.6222 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0202 | 0.2585 | 0.2585 |
Echinococcus granulosus | cyclins | 0.0248 | 0.3617 | 0.6222 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0092 | 0.013 | 0.0358 |
Brugia malayi | protein kinase C II. | 0.0306 | 0.4905 | 0.4905 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0206 | 0.2683 | 0.2683 |
Echinococcus granulosus | cyclin B3 1 | 0.0248 | 0.3617 | 0.6222 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.2585 | 0.4381 |
Trichomonas vaginalis | cyclins, putative | 0.0248 | 0.3617 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0285 | 0.4437 | 0.7687 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0202 | 0.2585 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0248 | 0.3617 | 0.6222 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0248 | 0.3617 | 1 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0202 | 0.2585 | 0.7148 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0965 | 0.0965 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0092 | 0.013 | 0.0358 |
Trypanosoma cruzi | cyclin, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0092 | 0.013 | 0.013 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0248 | 0.3617 | 0.3617 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0157 | 0.1588 | 0.4391 |
Trichomonas vaginalis | cyclin B, putative | 0.0248 | 0.3617 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0248 | 0.3617 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0248 | 0.3617 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0248 | 0.3617 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0248 | 0.3617 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0343 | 0.5734 | 1 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0202 | 0.2585 | 0.2585 |
Trichomonas vaginalis | cyclin A, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.6204 | 0.6204 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0092 | 0.013 | 0.0358 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0214 | 0.2859 | 0.4871 |
Trichomonas vaginalis | cyclins, putative | 0.0248 | 0.3617 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0306 | 0.4905 | 0.8522 |
Entamoeba histolytica | cyclin, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.3617 | 0.3617 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0229 | 0.3178 | 0.544 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0092 | 0.013 | 0.0358 |
Onchocerca volvulus | 0.0294 | 0.4626 | 1 | |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0202 | 0.2585 | 1 |
Schistosoma mansoni | cyclins | 0.0248 | 0.3617 | 0.6222 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.4626 | 0.4626 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.2585 | 0.4381 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.7042 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0306 | 0.4905 | 0.8522 |
Trypanosoma cruzi | cyclin, putative | 0.0248 | 0.3617 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0092 | 0.013 | 0.0358 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Trichomonas vaginalis | cyclin B, putative | 0.0248 | 0.3617 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Trichomonas vaginalis | cyclins, putative | 0.0248 | 0.3617 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0285 | 0.4437 | 0.7687 |
Leishmania major | cyclin | 0.0248 | 0.3617 | 1 |
Giardia lamblia | Cyclin A | 0.0248 | 0.3617 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.024 | 0.3437 | 0.5902 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0248 | 0.3617 | 0.3617 |
Trypanosoma cruzi | cyclin 6, putative | 0.0248 | 0.3617 | 1 |
Echinococcus multilocularis | cyclin B | 0.0248 | 0.3617 | 0.6222 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Brugia malayi | cell division control protein 2 homolog | 0.0092 | 0.013 | 0.013 |
Echinococcus multilocularis | cyclin b3 | 0.0248 | 0.3617 | 0.6222 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0206 | 0.2682 | 0.7417 |
Echinococcus granulosus | cyclins | 0.0248 | 0.3617 | 0.6222 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.2461 | 0.2461 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0306 | 0.4905 | 0.8522 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0092 | 0.013 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2543 | 0.2543 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0343 | 0.5734 | 0.5734 |
Trichomonas vaginalis | cyclins, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0092 | 0.013 | 0.013 |
Entamoeba histolytica | cyclin family protein | 0.0248 | 0.3617 | 1 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0202 | 0.2585 | 0.7042 |
Echinococcus granulosus | protein kinase C gamma type | 0.0214 | 0.2859 | 0.4871 |
Trichomonas vaginalis | cyclin D, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0883 | 0.0883 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Echinococcus granulosus | cyclins | 0.0248 | 0.3617 | 0.6222 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0136 | 0.1105 | 0.1105 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0206 | 0.2683 | 0.2683 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0202 | 0.2585 | 0.7148 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0139 | 0.1172 | 0.1172 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0202 | 0.2585 | 0.7042 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0534 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0247 | 0.3581 | 0.6159 |
Onchocerca volvulus | 0.02 | 0.2543 | 0.431 | |
Echinococcus granulosus | cyclin b3 | 0.0248 | 0.3617 | 0.6222 |
Trichomonas vaginalis | cyclin B, putative | 0.0248 | 0.3617 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0092 | 0.013 | 0.013 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0196 | 0.2445 | 0.4131 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0248 | 0.3617 | 0.6222 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0285 | 0.4437 | 0.7687 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.4626 | 0.4626 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0248 | 0.3617 | 0.3617 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0202 | 0.2585 | 0.7042 |
Onchocerca volvulus | 0.0205 | 0.264 | 0.4576 | |
Brugia malayi | Protein kinase c protein 2 | 0.0209 | 0.275 | 0.275 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0206 | 0.2682 | 0.7417 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0202 | 0.2585 | 0.7042 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0092 | 0.013 | 0.013 |
Giardia lamblia | Kinase, AGC PKA | 0.0202 | 0.2585 | 0.7042 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0126 | 0.0883 | 0.1344 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Onchocerca volvulus | 0.0248 | 0.3617 | 0.7242 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.2585 | 0.4381 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0202 | 0.2585 | 0.4381 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0202 | 0.2585 | 0.7042 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.6454 | 0.6454 |
Schistosoma mansoni | cyclin B3 | 0.0248 | 0.3617 | 0.6222 |
Echinococcus granulosus | protein kinase c iota type | 0.024 | 0.3437 | 0.5902 |
Leishmania major | protein kinase A catalytic subunit | 0.0202 | 0.2585 | 0.7042 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0202 | 0.2585 | 0.7042 |
Trichomonas vaginalis | AGC family protein kinase | 0.0202 | 0.2585 | 0.7148 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Echinococcus multilocularis | cyclin B3 1 | 0.0248 | 0.3617 | 0.6222 |
Echinococcus granulosus | cyclins | 0.0248 | 0.3617 | 0.6222 |
Trichomonas vaginalis | cyclin B3, putative | 0.0248 | 0.3617 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0171 | 0.1894 | 0.1894 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.4626 | 0.4626 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0153 | 0.1491 | 0.2429 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.3617 | 0.3617 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0092 | 0.013 | 0.0358 |
Brugia malayi | protein kinase C3,putative | 0.0165 | 0.175 | 0.175 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2585 | 0.2585 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0196 | 0.2445 | 0.4131 |
Brugia malayi | C1-like domain containing protein | 0.0206 | 0.2683 | 0.2683 |
Entamoeba histolytica | cyclin, putative | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0248 | 0.3617 | 0.3617 |
Trichomonas vaginalis | cyclin B, putative | 0.0248 | 0.3617 | 1 |
Giardia lamblia | Hypothetical protein | 0.0248 | 0.3617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.264 | 0.264 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0202 | 0.2585 | 0.2585 |
Toxoplasma gondii | AGC kinase | 0.0202 | 0.2585 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0248 | 0.3617 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0126 | 0.0883 | 0.1344 |
Echinococcus multilocularis | cyclins | 0.0248 | 0.3617 | 0.6222 |
Entamoeba histolytica | cyclin family protein | 0.0248 | 0.3617 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0126 | 0.0883 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0965 | 0.0965 |
Echinococcus granulosus | cyclin B | 0.0248 | 0.3617 | 0.6222 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative affinity (binding) | = 2.2 | Ability to compete with [125I]-Tyr(3)NT (0.15 nM) for human Neurotensin receptor 1 | ChEMBL. | 10579853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.