Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0065 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0118 | 0.4254 | 0.4254 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0189 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0189 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0065 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0065 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0189 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0189 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0118 | 0.4254 | 0.4254 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0189 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0189 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0065 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0118 | 0.4254 | 0.4254 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0189 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0065 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0065 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0189 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0065 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0189 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0189 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0065 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0189 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0065 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0118 | 0.4254 | 0.4254 |
Loa Loa (eye worm) | glutathione reductase | 0.0189 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0189 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0189 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.