Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0797 | 0.9602 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0797 | 0.9602 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0336 | 0.3611 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0336 | 0.3611 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0305 | 0.3213 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9246 | 0.963 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | 0 | Transcriptional activation of Retinoid X receptor RXR beta; NA is Not Active | ChEMBL. | 10585206 |
(binding) | 0 | In vitro binding affinity for RetinoidX receptor RXR beta; NT is Not Tested | ChEMBL. | 10585206 |
(functional) | 0 | Transcriptional activation of Retinoic acid receptor RAR alpha; NA is Not Active | ChEMBL. | 10585206 |
Affinity (binding) | In vitro binding affinity for RetinoidX receptor RXR beta; NT is Not Tested | ChEMBL. | 10585206 | |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoid X receptor RXR alpha | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoid X receptor RXR gamma | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoic acid receptor RAR beta | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoic acid receptor RAR gamma | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoid X receptor RXR alpha | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoid X receptor RXR gamma | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoic acid receptor RAR beta | ChEMBL. | 10585206 |
EC50 (functional) | > 1000 nM | Transcriptional activation of Retinoic acid receptor RAR gamma | ChEMBL. | 10585206 |
Expression (functional) | = 12.2 % | Granulocytic marker CD11b expression in HL-60 cell differentiation assay | ChEMBL. | 10585206 |
Expression (functional) | = 12.2 % | Granulocytic marker CD11b expression in HL-60 cell differentiation assay | ChEMBL. | 10585206 |
Expression (functional) | = 13 % | Granulocytic marker CD11b expression in HL-60 cell differentiation assay | ChEMBL. | 10585206 |
Expression (functional) | = 13 % | Granulocytic marker CD11b expression in HL-60 cell differentiation assay | ChEMBL. | 10585206 |
Expression (functional) | = 82.6 % | Monocytic marker CD14 expression in HL-60 cell differentiation assay | ChEMBL. | 10585206 |
Expression (functional) | = 82.6 % | Monocytic marker CD14 expression in HL-60 cell differentiation assay | ChEMBL. | 10585206 |
IC50 (functional) | = 74 uM | Cytostatic activity against HL-60 cells | ChEMBL. | 10585206 |
IC50 (functional) | = 74 uM | Cytostatic activity against HL-60 cells | ChEMBL. | 10585206 |
Kd (binding) | = 1000 nM | In vitro binding affinity for Retinoic acid receptor RAR alpha | ChEMBL. | 10585206 |
Kd (binding) | = 1000 nM | In vitro binding affinity for Retinoic acid receptor RAR alpha | ChEMBL. | 10585206 |
Kd (binding) | = 1400 nM | In vitro binding affinity for Retinoid X receptor RXR gamma | ChEMBL. | 10585206 |
Kd (binding) | = 1400 nM | In vitro binding affinity for Retinoid X receptor RXR gamma | ChEMBL. | 10585206 |
Kd (binding) | = 2000 nM | In vitro binding affinity for Retinoic acid receptor RAR gamma | ChEMBL. | 10585206 |
Kd (binding) | = 2000 nM | In vitro binding affinity for Retinoic acid receptor RAR gamma | ChEMBL. | 10585206 |
Kd (binding) | = 2100 nM | In vitro binding affinity for Retinoid X receptor RXR alpha | ChEMBL. | 10585206 |
Kd (binding) | = 2100 nM | In vitro binding affinity for Retinoid X receptor RXR alpha | ChEMBL. | 10585206 |
Kd (binding) | > 30000 nM | In vitro binding affinity for Retinoic acid receptor RAR beta | ChEMBL. | 10585206 |
Kd (binding) | > 30000 nM | In vitro binding affinity for Retinoic acid receptor RAR beta | ChEMBL. | 10585206 |
Transcriptional activation (functional) | Transcriptional activation of Retinoic acid receptor RAR alpha; NA is Not Active | ChEMBL. | 10585206 | |
Transcriptional activation (functional) | Transcriptional activation of Retinoid X receptor RXR beta; NA is Not Active | ChEMBL. | 10585206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.