Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0114 | 0.6378 | 0.6003 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.0968 | 0.0034 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0114 | 0.6378 | 0.6378 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0.0937 | 0.5 | |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0114 | 0.6378 | 1 |
Onchocerca volvulus | 0.0057 | 0.0937 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.4148 | 0.4148 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0057 | 0.0937 | 0.5 |
Brugia malayi | hypothetical protein | 0.0103 | 0.5249 | 0.474 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0968 | 0.0968 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.0968 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0.0937 | 0.5 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.0152 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0088 | 0.3837 | 0.5331 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0134 | 0.8233 | 0.8051 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7383 | 0.7383 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.8544 | 0.8544 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0114 | 0.6378 | 0.6003 |
Echinococcus granulosus | muscleblind protein | 0.0152 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.0968 | 0.0034 |
Onchocerca volvulus | 0.0057 | 0.0937 | 0.5 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.0968 | 0.0057 |
Echinococcus multilocularis | muscleblind protein | 0.0152 | 1 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.0968 | 0.0034 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.0968 | 0.0057 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 0.0968 | 0.0034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.24 uM | Concentration required to inhibit PAF-induced maximum platelet aggregation in rabbit platelet-rich plasma | ChEMBL. | 8558517 |
ID50 (functional) | = 0.0037 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through intravenous route | ChEMBL. | 8558517 |
ID50 (functional) | = 0.0037 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through intravenous route | ChEMBL. | 8558517 |
ID50 (functional) | = 0.011 mg kg-1 | Dose required to reduce the lowering of the arterial blood pressure caused by PAF by 50% after intravenous administration in rats | ChEMBL. | 8558517 |
ID50 (functional) | > 1 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through oral administration | ChEMBL. | 8558517 |
ID50 (functional) | > 1 mg kg-1 | Dosage required to inhibit PAF-induced mortality in mice by 50% through oral administration | ChEMBL. | 8558517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.