TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.475 | Formula: C20H30N4O7
H donors: 7 H acceptors: 4 LogP: -2.23 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: NCC1OC(OC2C(NC(=O)OCc3ccccc3)CC(C(C2O)O)N)C2C(C1O)N2
InChi: 1S/C20H30N4O7/c21-7-12-16(26)13-14(24-13)19(30-12)31-18-11(6-10(22)15(25)17(18)27)23-20(28)29-8-9-4-2-1-3-5-9/h1-5,10-19,24-27H,6-8,21-22H2,(H,23,28)
InChiKey: URJDZGOEGYNFHI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0021	0.0446	0.0338
Echinococcus multilocularis	cpg binding protein	0.0028	0.0631	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0021	0.0446	0.0376
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0021	0.0446	0.0338
Loa Loa (eye worm)	blistered cuticle protein 3	0.0084	0.212	0.2029
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0021	0.0446	0.0376
Echinococcus multilocularis	two pore calcium channel protein 2	0.0021	0.0446	0.0376
Echinococcus granulosus	carbonic anhydrase	0.0179	0.4645	0.4606
Schistosoma mansoni	notch	0.0027	0.0618	0.0618
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0021	0.0446	0.0376
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0021	0.0446	0.0376
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.212	0.2031
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0381	1	1
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0021	0.0446	0.0446
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.212	0.2031
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0021	0.0446	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Echinococcus granulosus	sodium channel protein	0.0021	0.0446	0.0376
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0021	0.0446	1
Echinococcus multilocularis	peroxidasin	0.0084	0.212	0.2062
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Onchocerca volvulus	Slit protein homolog	0.0027	0.0618	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Echinococcus granulosus	neurogenic locus notch protein 4	0.0027	0.0618	0.0549
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0381	1	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Echinococcus granulosus	protein jagged 1	0.0027	0.0618	0.0549
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0446	0.0446
Echinococcus granulosus	voltage gated potassium channel	0.0021	0.0446	0.0376
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0021	0.0446	0.0376
Echinococcus multilocularis	two pore calcium channel protein 1	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0021	0.0446	0.0446
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0021	0.0446	0.0338
Schistosoma mansoni	carbonic anhydrase-related	0.0179	0.4645	0.4645
Brugia malayi	olfactory channel protein osm-9	0.0021	0.0446	0.0338
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0021	0.0446	0.0338
Echinococcus granulosus	carbonic anhydrase	0.0179	0.4645	0.4606
Echinococcus granulosus	cpg binding protein	0.0028	0.0631	0.0562
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0591	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Echinococcus multilocularis	voltage gated potassium channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Brugia malayi	Cadherin domain containing protein	0.0027	0.0618	0.0512
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.0446	0.0376
Echinococcus granulosus	transient receptor potential cation channel	0.0021	0.0446	0.0376
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Onchocerca volvulus		0.0027	0.0618	0.1029
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0027	0.0618	0.1029
Schistosoma mansoni	septate junction protein	0.0027	0.0618	0.0618
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0115	0.0042
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Brugia malayi	notch-like transmembrane receptor	0.0027	0.0618	0.0512
Echinococcus multilocularis	neurogenic locus protein delta	0.0027	0.0618	0.0549
Schistosoma mansoni	carbonic anhydrase	0.0179	0.4645	0.4645
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0179	0.4645	0.4583
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0021	0.0446	0.0335
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Onchocerca volvulus	Dual oxidase homolog	0.0084	0.212	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0381	1	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0021	0.0446	0.0446
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Echinococcus granulosus	peroxidasin	0.0084	0.212	0.2062
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0021	0.0446	0.0338
Echinococcus granulosus	neural cadherin	0.0027	0.0618	0.0549
Echinococcus granulosus	sodium leak channel non selective protein	0.0021	0.0446	0.0376
Brugia malayi	voltage-dependent calcium channel	0.0021	0.0446	0.0338
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Echinococcus granulosus	carbonic anhydrase II	0.0381	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.212	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0021	0.0446	0.0376
Schistosoma mansoni	calcium-activated potassium channel	0.0294	0.7683	0.7683
Plasmodium falciparum	carbonic anhydrase	0.0179	0.4645	1
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0021	0.0446	0.0376
Echinococcus multilocularis	transient receptor potential gamma protein	0.0021	0.0446	0.0376
Echinococcus granulosus	transient receptor potential cation channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0021	0.0446	0.0446
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0179	0.4645	0.4584
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.212	0.2031
Echinococcus granulosus	hyperpolarization activated cyclic	0.0021	0.0446	0.0376
Schistosoma mansoni	voltage-gated cation channel	0.0021	0.0446	0.0446
Echinococcus granulosus	transient receptor potential cation channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Echinococcus multilocularis	fibropellin Ia	0.0027	0.0618	0.0549
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.0446	0.0376
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0021	0.0446	0.0376
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0021	0.0446	0.0376
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0078	0.197	0.1595
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Schistosoma mansoni	cpg binding protein	0.0028	0.0631	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Plasmodium vivax	potassium channel, putative	0.0078	0.197	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0027	0.0618	0.0618
Schistosoma mansoni	cpg binding protein	0.0026	0.0591	0.0591
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0021	0.0446	0.0376
Onchocerca volvulus	Peroxidasin homolog	0.0084	0.212	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0021	0.0446	0.0376
Schistosoma mansoni	two-pore calcium channel	0.0021	0.0446	0.0446
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0021	0.0446	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Schistosoma mansoni	voltage-dependent calcium channel	0.0021	0.0446	0.0446
Onchocerca volvulus		0.0027	0.0618	0.1029
Echinococcus multilocularis	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.0446	0.0376
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0055	0.1365	0.1365
Brugia malayi	cation channel family protein	0.0021	0.0446	0.0338
Schistosoma mansoni	peroxidasin	0.0084	0.212	0.212
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0179	0.4645	0.4584
Echinococcus granulosus	voltage dependent calcium channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	Notch2	0.0027	0.0618	0.0509
Onchocerca volvulus	Peroxidase homolog	0.0084	0.212	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Echinococcus multilocularis	slit 2 protein	0.0027	0.0618	0.0549
Schistosoma mansoni	cpg binding protein	0.0028	0.0631	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0115	0.0042
Schistosoma mansoni	notch	0.0027	0.0618	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Echinococcus granulosus	carbonic anhydrase	0.0179	0.4645	0.4606
Echinococcus multilocularis	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Echinococcus multilocularis	transfer RNA-Gly	0.0021	0.0446	0.0376
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Echinococcus granulosus	protein jagged 1	0.0027	0.0618	0.0549
Schistosoma mansoni	notch	0.0027	0.0618	0.0618
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0618	0.0512
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0021	0.0446	0.0338
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0021	0.0446	0.0338
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0021	0.0446	0.0376
Echinococcus multilocularis	protein jagged 1	0.0027	0.0618	0.0549
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Schistosoma mansoni	notch	0.0027	0.0618	0.0618
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0027	0.0618	0.0549
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.212	0.2029
Echinococcus multilocularis	calcium activated potassium channel variant	0.0273	0.7138	0.7117
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus multilocularis	sodium leak channel non selective protein	0.0021	0.0446	0.0376
Echinococcus multilocularis	carbonic anhydrase	0.0179	0.4645	0.4606
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Brugia malayi	Transient-receptor-potential like protein	0.0021	0.0446	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Onchocerca volvulus		0.0027	0.0618	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0021	0.0446	0.0446
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	ryanodine receptor	0.0021	0.0446	0.0335
Echinococcus multilocularis	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0021	0.0446	0.0446
Echinococcus multilocularis	neural cadherin	0.0027	0.0618	0.0549
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0021	0.0446	0.0446
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0021	0.0446	0.0376
Echinococcus granulosus	TRP transient receptor potential channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0179	0.4645	0.4584
Loa Loa (eye worm)	notch protein	0.0027	0.0618	0.0509
Schistosoma mansoni	notch	0.0027	0.0618	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0021	0.0446	0.0338
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0591	0.0485
Echinococcus multilocularis	protein jagged 2	0.0027	0.0618	0.0549
Schistosoma mansoni	cell polarity protein	0.0027	0.0618	0.0618
Leishmania major	carbonic anhydrase-like protein	0.0381	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.212	0.2029
Schistosoma mansoni	peroxidasin	0.0084	0.212	0.212
Echinococcus multilocularis	neurogenic locus notch protein	0.0027	0.0618	0.0549
Echinococcus granulosus	two pore calcium channel protein 1	0.0021	0.0446	0.0376
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Giardia lamblia	High cysteine protein	0.0027	0.0618	0.5
Brugia malayi	GCC2 and GCC3 family protein	0.0027	0.0618	0.0512
Onchocerca volvulus	Peroxidase homolog	0.0084	0.212	1
Schistosoma mansoni	transient receptor potential channel	0.0021	0.0446	0.0446
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0021	0.0446	0.0376
Echinococcus granulosus	protein jagged 2	0.0027	0.0618	0.0549
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0021	0.0446	0.0376
Brugia malayi	cation channel family protein	0.0021	0.0446	0.0338
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0179	0.4645	0.4584
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0078	0.197	0.1595
Loa Loa (eye worm)	voltage-gated potassium channel	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4645	0.4583
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Brugia malayi	Cadherin domain containing protein	0.0027	0.0618	0.0512
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.0446	0.0376
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0049	0.1209	0.1817
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4645	0.4583
Echinococcus multilocularis	shaker cognate	0.0021	0.0446	0.0376
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0027	0.0618	0.0549
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0021	0.0446	0.0335
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Onchocerca volvulus		0.0084	0.212	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0021	0.0446	0.0376
Schistosoma mansoni	60S ribosomal protein L21	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Echinococcus granulosus	transient receptor potential cation channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0484	0.0373
Echinococcus granulosus	delta-like protein 1	0.0027	0.0618	0.0549
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0273	0.7138	0.7105
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0021	0.0446	0.0338
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0021	0.0446	0.0376
Schistosoma mansoni	hypothetical protein	0.0179	0.4645	0.4645
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0381	1	1
Schistosoma mansoni	carbonic anhydrase-related	0.0179	0.4645	0.4645
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0021	0.0446	0.0376
Echinococcus granulosus	ryanodine receptor 44f	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0021	0.0446	0.0446
Echinococcus multilocularis	conserved hypothetical protein	0.0021	0.0446	0.0376
Echinococcus granulosus	shaker cognate	0.0021	0.0446	0.0376
Echinococcus granulosus	transient receptor potential gamma protein	0.0021	0.0446	0.0376
Onchocerca volvulus		0.0084	0.212	1
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.212	0.2029
Echinococcus multilocularis	carbonic anhydrase	0.0179	0.4645	0.4606
Echinococcus granulosus	voltage gated potassium channel	0.0021	0.0446	0.0376
Echinococcus multilocularis	calcium activated potassium channel	0.0294	0.7683	0.7666
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	MaxiK calcium-activated potassium channel	0.0195	0.507	0.5012
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0618	0.0512
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.212	0.2031
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0381	1	1
Echinococcus multilocularis	carbonic anhydrase	0.0179	0.4645	0.4606
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0021	0.0446	0.0376
Echinococcus multilocularis	short transient receptor potential channel 6	0.0021	0.0446	0.0376
Echinococcus multilocularis	ryanodine receptor 44f	0.0021	0.0446	0.0376
Schistosoma mansoni	voltage-gated ion channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0021	0.0446	0.0335
Onchocerca volvulus		0.0027	0.0618	0.1029
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0021	0.0446	0.0376
Schistosoma mansoni	laminin gamma-3 chain	0.0027	0.0618	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	hypothetical protein	0.0021	0.0446	0.0376
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0021	0.0446	0.0338
Brugia malayi	Blistered cuticle protein 3	0.0084	0.212	0.2031
Brugia malayi	Peroxidasin	0.0084	0.212	0.2031
Loa Loa (eye worm)	carbonic anhydrase 3	0.0381	1	1
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0021	0.0446	0.0446
Toxoplasma gondii	ion channel protein	0.0078	0.197	0.3629
Echinococcus granulosus	short transient receptor potential channel 6	0.0021	0.0446	0.0376
Leishmania major	calcium/potassium channel (CAKC), putative	0.0078	0.197	0.1595
Loa Loa (eye worm)	voltage-gated calcium channel	0.0021	0.0446	0.0335
Schistosoma mansoni	vesicular amine transporter	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0021	0.0446	0.0376
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0381	1	1
Brugia malayi	hypothetical protein	0.0021	0.0446	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Echinococcus granulosus	neurogenic locus notch protein	0.0027	0.0618	0.0549
Brugia malayi	Calcium binding EGF domain containing protein	0.0027	0.0618	0.0512
Brugia malayi	ion channel NompC	0.0021	0.0446	0.0338
Toxoplasma gondii	ion channel protein	0.0078	0.197	0.3629
Echinococcus granulosus	neurogenic locus protein delta	0.0027	0.0618	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	potassium large conductance calcium activated	0.0294	0.7683	0.7666
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Echinococcus granulosus	short transient receptor potential channel 6	0.0021	0.0446	0.0376
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Echinococcus granulosus	transient receptor potential cation channel	0.0021	0.0446	0.0376
Schistosoma mansoni	calcium-activated potassium channel	0.0273	0.7138	0.7138
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0021	0.0446	0.0338
Echinococcus multilocularis	notch	0.0027	0.0618	0.0549
Echinococcus multilocularis	voltage dependent calcium channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Echinococcus granulosus	hyperpolarization activated cyclic	0.0021	0.0446	0.0376
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0195	0.507	0.5012
Loa Loa (eye worm)	calcium channel	0.0021	0.0446	0.0335
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0078	0.197	0.1595
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0072	0.0072
Onchocerca volvulus	Peroxidasin homolog	0.0084	0.212	1
Echinococcus granulosus	voltage dependent calcium channel	0.0021	0.0446	0.0376
Echinococcus granulosus	two pore calcium channel protein 2	0.0021	0.0446	0.0376
Toxoplasma gondii	hypothetical protein	0.0179	0.4645	1
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0021	0.0446	0.0376
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0021	0.0446	0.0338
Echinococcus multilocularis	sodium channel protein	0.0021	0.0446	0.0376
Echinococcus granulosus	calcium activated potassium channel variant	0.0273	0.7138	0.7117
Echinococcus granulosus	neurogenic locus notch protein	0.0027	0.0618	0.0549
Leishmania major	hypothetical protein, conserved	0.0078	0.197	0.1595
Echinococcus granulosus	fibropellin Ia	0.0027	0.0618	0.0549
Echinococcus granulosus	slit 2 protein	0.0027	0.0618	0.0549
Onchocerca volvulus	Neurogenic locus notch homolog	0.0027	0.0618	0.1029
Echinococcus multilocularis	voltage gated potassium channel	0.0021	0.0446	0.0376
Echinococcus granulosus	notch	0.0027	0.0618	0.0549
Schistosoma mansoni	transient receptor potential channel 4	0.0021	0.0446	0.0446
Schistosoma mansoni	slit	0.0027	0.0618	0.0618
Brugia malayi	Delta serrate ligand family protein	0.0027	0.0618	0.0512
Schistosoma mansoni	transient receptor potential channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	voltage-gated potassium channel	0.0021	0.0446	0.0335
Onchocerca volvulus		0.0026	0.0591	0.0869
Onchocerca volvulus		0.0027	0.0618	0.1029
Echinococcus multilocularis	potassium large conductance calcium activated	0.0294	0.7683	0.7666
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Echinococcus multilocularis	voltage dependent calcium channel	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Brugia malayi	Muscle positioning protein 4	0.0027	0.0618	0.0512
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Schistosoma mansoni	calcium-activated potassium channel	0.0078	0.197	0.197
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0021	0.0446	0.0376
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0021	0.0446	0.0446
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0021	0.0446	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Echinococcus granulosus	protein jagged 2	0.0027	0.0618	0.0549
Schistosoma mansoni	transient receptor potential channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0618	0.0509
Onchocerca volvulus	Putative cubilin	0.0027	0.0618	0.1029
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0179	0.4645	0.4584
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0021	0.0446	0.0446
Schistosoma mansoni	ryanodine receptor related	0.0021	0.0446	0.0446
Echinococcus multilocularis	neurogenic locus notch protein	0.0027	0.0618	0.0549
Toxoplasma gondii	EGF family domain-containing protein	0.0027	0.0618	0.041
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0195	0.507	0.5014
Echinococcus multilocularis	transient receptor potential cation channel	0.0021	0.0446	0.0376
Echinococcus multilocularis	short transient receptor potential channel 6	0.0021	0.0446	0.0376
Trypanosoma brucei	carbonic anhydrase-like protein	0.0381	1	1
Onchocerca volvulus		0.0084	0.212	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0021	0.0446	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0078	0.197	0.1877
Echinococcus multilocularis	protein jagged 1	0.0027	0.0618	0.0549
Echinococcus granulosus	calcium activated potassium channel	0.0294	0.7683	0.7666
Loa Loa (eye worm)	hypothetical protein	0.0084	0.212	0.2029
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Echinococcus multilocularis	carbonic anhydrase II	0.0381	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0021	0.0446	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0179	0.4645	0.4583
Echinococcus granulosus	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0021	0.0446	0.0376
Echinococcus multilocularis	neurogenic locus protein delta	0.0027	0.0618	0.0549
Schistosoma mansoni	hypothetical protein	0.0027	0.0618	0.0618
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.212	0.2029
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0027	0.0618	0.0512
Brugia malayi	EGF-like domain containing protein	0.0027	0.0618	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Brugia malayi	hypothetical protein	0.0084	0.212	0.2031
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0021	0.0446	0.0376
Echinococcus granulosus	potassium voltage gated channel protein	0.0021	0.0446	0.0376
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Schistosoma mansoni	notch	0.0027	0.0618	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Schistosoma mansoni	carbonic anhydrase-related	0.0179	0.4645	0.4645
Onchocerca volvulus	Chorion peroxidase homolog	0.0084	0.212	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0021	0.0446	0.0338
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0484	0.0376
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0446	0.0446
Echinococcus granulosus	transient receptor potential cation channel	0.0021	0.0446	0.0376
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0446	0.0446
Loa Loa (eye worm)	ion channel NompC	0.0021	0.0446	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0446	0.0335
Schistosoma mansoni	hypothetical protein	0.0021	0.0446	0.0446
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0021	0.0446	0.0376

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 63 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20507, in combination with Kanamycin A at specified concentration	ChEMBL.	6244410
MIC (functional)	= 63 ug ml-1	Minimum inhibitory concentration of the compound was measured against Proteus rettgeri A 21615, in combination with Kanamycin A at specified concentration.	ChEMBL.	6244410
MIC (functional)	= 63 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20507, in combination with Kanamycin A at specified concentration	ChEMBL.	6244410
MIC (functional)	= 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20665	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20507	ChEMBL.	6244410
MIC (functional)	= 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 9632	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Proteus rettgeri A 21615	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Proteus rettgeri A 9637	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Pseudomonas aeruginosa A 20653	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Pseudomonas aeruginosa A 20357	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20665, in combination with Kanamycin A at 8 ug/mL concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20507, in combination with Kanamycin A at 8 ug/mL concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Proteus rettgeri A 21615, in combination with Kanamycin A at 8 ug/mL concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Pseudomonas aeruginosa A 20653, in combination with Kanamycin A at 8 ug/mL concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20665, in combination with Kanamycin A at specified concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Pseudomonas aeruginosa A 20653 in combination with Kanamycin A at specified concentration.	ChEMBL.	6244410
MIC (functional)	= 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20665	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20507	ChEMBL.	6244410
MIC (functional)	= 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 9632	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20665, in combination with Kanamycin A at 8 ug/mL concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20507, in combination with Kanamycin A at 8 ug/mL concentration	ChEMBL.	6244410
MIC (functional)	> 125 ug ml-1	Minimum inhibitory concentration of the compound was measured against Escherichia coli A 20665, in combination with Kanamycin A at specified concentration	ChEMBL.	6244410

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL147278

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 251928