Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0574 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1747 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.1747 | 0.1747 |
Echinococcus multilocularis | acetylcholinesterase | 0.0574 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0574 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0574 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0574 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0574 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0574 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0574 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0574 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0574 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.8 nM | Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor | ChEMBL. | 10585208 |
EC50 (binding) | = 0.8 nM | Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor | ChEMBL. | 10585208 |
Efficacy (functional) | = 74 % | Maximum stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing human 5-HT-1d relative to 5-HT | ChEMBL. | 10585208 |
Efficacy (functional) | = 74 % | Maximum stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing human 5-HT-1d relative to 5-HT | ChEMBL. | 10585208 |
IC50 (binding) | = 0.7 nM | Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
IC50 (binding) | = 0.7 nM | Displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
IC50 (binding) | = 100 nM | Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
IC50 (binding) | = 100 nM | Displacement of [3H]-5-HT binding to cloned 5-hydroxytryptamine 1B receptor stably expressed in CHO cells | ChEMBL. | 10585208 |
Selectivity (binding) | = 140 | Ratio of IC50 for human 5-HT1B to human 5-HT1D receptors | ChEMBL. | 10585208 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.