Detailed information for compound 252330

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 273.759 | Formula: C12H20ClN3O2
  • H donors: 1 H acceptors: 1 LogP: 2.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C/c1[n+](COC2CCCCC2)ccn1C.[Cl-]
  • InChi: 1S/C12H19N3O2.ClH/c1-14-7-8-15(12(14)9-13-16)10-17-11-5-3-2-4-6-11;/h7-9,11H,2-6,10H2,1H3;1H
  • InChiKey: GMYHTBNBDYNDAI-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0081 0.0097
Echinococcus multilocularis adenosylhomocysteinase 0.0266 0.3961 0.3961
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0266 0.3961 1
Leishmania major cysteine peptidase A (CPA) 0.0047 0.0582 0.1375
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.1203 0.1715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0645 0.0645
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0015 0.0081 0.0081
Plasmodium vivax unspecified product 0.0015 0.0081 0.0061
Toxoplasma gondii cathepsin CPC2 0.0015 0.0081 0.0204
Brugia malayi cathepsin F-like cysteine proteinase 0.0013 0.0057 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0645 0.0645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0266 0.3961 1
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0252 0.3745 0.3745
Loa Loa (eye worm) MBCTL1 0.0061 0.0792 0.113
Entamoeba histolytica cysteine protease, putative 0.0047 0.0582 0.1375
Echinococcus multilocularis muscleblind protein 0.0465 0.7015 0.7015
Brugia malayi Cathepsin L-like precursor 0.0047 0.0582 0.0829
Giardia lamblia Cathepsin B precursor 0.0088 0.1214 1
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0081 0.0081
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0582 0.0829
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0281 0.0281
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0266 0.3961 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0081 0.0115
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0284 0.0615
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0015 0.0081 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0081 0.0097
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Trypanosoma brucei AMP deaminase, putative 0.0083 0.1132 0.2781
Plasmodium vivax adenosine/AMP deaminase, putative 0.0083 0.1132 0.2754
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0083 0.1132 0.2781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0379 0.0857
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0015 0.0081 0.0667
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0678 0.0678
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0645 0.0645
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0027 0.0278 0.0599
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0284 0.0284
Giardia lamblia Cathepsin B precursor 0.0088 0.1214 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0027 0.0278 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Plasmodium falciparum serine repeat antigen 3 0.0015 0.0081 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Trypanosoma brucei AMP deaminase, putative 0.0083 0.1132 0.2781
Loa Loa (eye worm) RNA binding protein 0.0071 0.0949 0.1352
Entamoeba histolytica adenosine deaminase, putative 0.0255 0.3777 0.9532
Treponema pallidum adenosine deaminase 0.0255 0.3777 0.5
Brugia malayi TAR-binding protein 0.0071 0.0949 0.1352
Echinococcus granulosus tar DNA binding protein 0.0071 0.0949 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0284 0.0615
Schistosoma mansoni adenosine deaminase 0.0255 0.3777 0.3777
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0027 0.0278 0.0599
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.1203 0.1715
Loa Loa (eye worm) hypothetical protein 0.0034 0.0379 0.054
Loa Loa (eye worm) hypothetical protein 0.0172 0.2499 0.3563
Loa Loa (eye worm) cathepsin B 0.0088 0.1214 0.1731
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0949 0.0949
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0284 0.0717
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0582 0.1355
Toxoplasma gondii preprocathepsin c precursor, putative 0.0015 0.0081 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0645 0.0919
Loa Loa (eye worm) hypothetical protein 0.0028 0.0281 0.0401
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0582 0.0582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Echinococcus multilocularis muscleblind protein 1 0.0465 0.7015 0.7015
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0949 0.0949
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0284 0.0615
Trypanosoma cruzi cruzipain precursor, putative 0.0013 0.0057 0.0037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0013 0.0057 0.0082
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0582 0.1375
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0015 0.0081 0.0115
Schistosoma mansoni hypothetical protein 0.0122 0.1735 0.1735
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0081 0.0667
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0582 0.1375
Giardia lamblia Encystation-specific protease 0.0015 0.0081 0.0667
Brugia malayi adenosine monophosphate deaminase 0.0083 0.1132 0.1614
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0015 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0081 0.0097
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0015 0.0081 0.0061
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0266 0.3961 1
Schistosoma mansoni cathepsin F (C01 family) 0.0047 0.0582 0.0582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Giardia lamblia Hypothetical protein 0.0015 0.0081 0.0667
Giardia lamblia Cathepsin L precursor 0.0015 0.0081 0.0667
Onchocerca volvulus 0.0047 0.0582 0.1355
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0379 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0284 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0081 0.0667
Trichomonas vaginalis adenosine deaminase, putative 0.0255 0.3777 0.9532
Loa Loa (eye worm) hypothetical protein 0.0083 0.1132 0.1614
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0281 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0015 0.0081 0.0667
Giardia lamblia Cathepsin B precursor 0.0015 0.0081 0.0667
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0582 0.0829
Giardia lamblia Cysteine protease 0.0015 0.0081 0.0667
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0083 0.1132 0.2781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0088 0.1214 0.1214
Plasmodium vivax serine-repeat antigen (SERA) 0.0015 0.0081 0.0061
Schistosoma mansoni adenosylhomocysteinase 0.0165 0.2395 0.2395
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0115
Echinococcus multilocularis cathepsin L 0.0028 0.0284 0.0284
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0792 0.0792
Echinococcus granulosus cathepsin l cysteine peptidase 0.0047 0.0582 0.0582
Brugia malayi Adenosylhomocysteinase 0.0266 0.3961 0.5646
Schistosoma mansoni hypothetical protein 0.0028 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0015 0.0081 0.0097
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0081 0.0097
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0015 0.0081 0.0061
Entamoeba histolytica cysteine protease, putative 0.0015 0.0081 0.0097
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0015 0.0081 0.0097
Entamoeba histolytica cysteine protease, putative 0.0015 0.0081 0.0097
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0949 0.1352
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0255 0.3777 0.9537
Entamoeba histolytica AMP deaminase, putative 0.0083 0.1132 0.2781
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0013 0.0057 0.0082
Trypanosoma cruzi AMP deaminase, putative 0.0083 0.1132 0.2781
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0027 0.0278 0.0701
Plasmodium vivax unspecified product 0.0028 0.0284 0.0581
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0582 0.1375
Onchocerca volvulus 0.0047 0.0582 0.1355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0081 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0061 0.0792 0.113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0081 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0949 0.0949
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0281 0.0281
Brugia malayi Cathepsin L-like precursor 0.0047 0.0582 0.0829
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0083 0.1132 0.2781
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Toxoplasma gondii adenosylhomocysteinase, putative 0.0266 0.3961 1
Echinococcus multilocularis cathepsin L 0.0015 0.0081 0.0081
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0081 0.0081
Plasmodium falciparum AMP deaminase, putative 0.0083 0.1132 0.2859
Schistosoma mansoni microtubule-associated protein tau 0.0658 1 1
Onchocerca volvulus 0.0047 0.0582 0.1355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0015 0.0081 0.0061
Giardia lamblia Cathepsin B precursor 0.0015 0.0081 0.0667
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0015 0.0081 0.0204
Loa Loa (eye worm) hypothetical protein 0.0465 0.7015 1
Echinococcus granulosus adenosylhomocysteinase 0.0266 0.3961 0.3961
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0015 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0082
Echinococcus multilocularis cathepsin b 0.0252 0.3745 0.3745
Brugia malayi Cathepsin L-like precursor 0.0034 0.0379 0.054
Echinococcus granulosus cysteine protease 0.0028 0.0284 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0645 0.0645
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0678 0.0678
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0252 0.3745 0.3745
Loa Loa (eye worm) hypothetical protein 0.0047 0.0582 0.0829
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0027 0.0278 0.0599
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0792 0.0792
Schistosoma mansoni adenosylhomocysteinase 0.0266 0.3961 0.3961
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0081 0.0097
Onchocerca volvulus AMP deaminase 2 homolog 0.0083 0.1132 0.2844
Onchocerca volvulus Cathepsin L homolog 0.0047 0.0582 0.1355
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0015 0.0081 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0115
Giardia lamblia Cathepsin B precursor 0.0015 0.0081 0.0667
Onchocerca volvulus 0.0053 0.0678 0.1616
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Giardia lamblia Cysteine protease 0.0015 0.0081 0.0667
Toxoplasma gondii AMP deaminase 0.0083 0.1132 0.2859
Trypanosoma cruzi major cysteine proteinase, putative 0.0015 0.0081 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0582 0.1375
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0015 0.0081 0.0061
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0207 0.0295
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0266 0.3961 1
Brugia malayi cathepsin L-like precursor 0.0034 0.0379 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0645 0.0645
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0027 0.0278 0.0278
Giardia lamblia Cysteine protease 0.0015 0.0081 0.0667
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0582 0.1375
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0252 0.3745 0.3745
Trypanosoma brucei AMP deaminase, putative 0.0083 0.1132 0.2781
Loa Loa (eye worm) hypothetical protein 0.0034 0.0379 0.054
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0027 0.0278 0.0278
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0134 0.0233
Echinococcus granulosus cathepsin b 0.0252 0.3745 0.3745
Toxoplasma gondii cathepsin CPL 0.0047 0.0582 0.1469
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0082
Schistosoma mansoni cathepsin B (C01 family) 0.0015 0.0081 0.0081
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0582 0.0582
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0027 0.0278 0.0278
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.1203 0.1715
Schistosoma mansoni hypothetical protein 0.0325 0.4864 0.4864
Loa Loa (eye worm) hypothetical protein 0.0088 0.1203 0.1715
Brugia malayi Cathepsin L-like precursor 0.0047 0.0582 0.0829
Plasmodium falciparum serine repeat antigen 5 0.0015 0.0081 0.0204
Onchocerca volvulus 0.0047 0.0582 0.1355
Loa Loa (eye worm) hypothetical protein 0.0172 0.2499 0.3563
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0015 0.0081 0.0061
Schistosoma mansoni adenosylhomocysteinase 0.0165 0.2395 0.2395
Leishmania major adenine aminohydrolase 0.0255 0.3777 0.9532
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0115
Onchocerca volvulus 0.0034 0.0379 0.0805
Trypanosoma cruzi AMP deaminase, putative 0.0083 0.1132 0.2781
Trypanosoma brucei cysteine peptidase C (CPC) 0.0088 0.1214 0.299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0081 0.0115
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0084 0.1143 0.2809
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0284 0.0615
Plasmodium vivax vivapain-2 0.0047 0.0582 0.1343
Loa Loa (eye worm) hypothetical protein 0.0465 0.7015 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0047 0.0582 0.0582
Plasmodium falciparum serine repeat antigen 2 0.0015 0.0081 0.0204
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0081 0.0115
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0284 0.0615
Echinococcus multilocularis cathepsin b 0.0252 0.3745 0.3745
Giardia lamblia Cathepsin L precursor 0.0015 0.0081 0.0667
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0284 0.0615
Schistosoma mansoni cathepsin C 0.0015 0.0081 0.0081
Onchocerca volvulus Adenosine deaminase homolog 0.0255 0.3777 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0015 0.0081 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0949 0.0949
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0284 0.0615
Brugia malayi hypothetical protein 0.0018 0.0134 0.0191
Brugia malayi Cathepsin L-like precursor 0.0047 0.0582 0.0829
Giardia lamblia Cathepsin L-like protease 0.0015 0.0081 0.0667
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0088 0.1214 0.299
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0115
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0678 0.0967
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Entamoeba histolytica cysteine protease, putative 0.0015 0.0081 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0081 0.0097
Schistosoma mansoni adenosylhomocysteinase 0.0165 0.2395 0.2395
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0284 0.0615
Plasmodium falciparum cysteine proteinase falcipain 3 0.0047 0.0582 0.1469
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0645 0.0645
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0284 0.0284
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0015 0.0081 0.0061
Entamoeba histolytica hypothetical protein 0.0015 0.0081 0.0097
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0015 0.0081 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Trichomonas vaginalis adenosine deaminase, putative 0.0255 0.3777 0.9532
Loa Loa (eye worm) AMP deaminase 0.0083 0.1132 0.1614
Brugia malayi Cathepsin L-like precursor 0.0013 0.0057 0.0082
Schistosoma mansoni hypothetical protein 0.0028 0.0281 0.0281
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0081 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Schistosoma mansoni hypothetical protein 0.006 0.0776 0.0776
Brugia malayi Adenosine/AMP deaminase family protein 0.0255 0.3777 0.5385
Giardia lamblia Cathepsin L precursor 0.0015 0.0081 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Brugia malayi cathepsin L-like cysteine proteinase 0.0015 0.0081 0.0115
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Toxoplasma gondii cathepsin B 0.0088 0.1214 0.3065
Leishmania major hypothetical protein, conserved 0.0083 0.1132 0.2781
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0027 0.0278 0.0599
Brugia malayi mbt repeat family protein 0.0053 0.0678 0.0967
Plasmodium falciparum serine repeat antigen 4 0.0015 0.0081 0.0204
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0164 0.0415
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0083 0.1132 0.2781
Onchocerca volvulus 0.0047 0.0582 0.1355
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0081 0.0115
Loa Loa (eye worm) adenosylhomocysteinase 0.0266 0.3961 0.5646
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Loa Loa (eye worm) hypothetical protein 0.0252 0.3745 0.5338
Plasmodium vivax vivapain-2 0.0047 0.0582 0.1343
Onchocerca volvulus Cathepsin F homolog 0.0047 0.0582 0.1355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0081 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0134 0.0233
Loa Loa (eye worm) transcription factor SMAD2 0.0086 0.1179 0.1681
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0284 0.0615
Loa Loa (eye worm) RecQ helicase 0.0023 0.0207 0.0295
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0678 0.0678
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0379 0.0379
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0379 0.0857
Giardia lamblia Cysteine protease 0.0015 0.0081 0.0667
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0582 0.1375
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0027 0.0278 0.0565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Plasmodium vivax adenosine deaminase, putative 0.0255 0.3777 0.9531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0134 0.0233
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0081 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0582 0.1375
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0015 0.0081 0.0061
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0027 0.0278 0.0599
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0281 0.0401
Echinococcus granulosus cathepsin l1 0.0047 0.0582 0.0582
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0255 0.3777 0.9537
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0645 0.0645
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0266 0.3961 1
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0266 0.3961 1
Echinococcus granulosus muscleblind protein 0.0465 0.7015 0.7015
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0949 0.0949
Brugia malayi mbt repeat family protein 0.0053 0.0678 0.0967
Giardia lamblia Cathepsin L precursor 0.0015 0.0081 0.0667
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0057 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0379 0.0857
Loa Loa (eye worm) hypothetical protein 0.0172 0.2499 0.3563
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0582 0.1375
Schistosoma mansoni hypothetical protein 0.0028 0.0281 0.0281
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0266 0.3961 1
Plasmodium vivax vivapain-1 0.0028 0.0284 0.0581
Loa Loa (eye worm) hypothetical protein 0.0255 0.3777 0.5385
Schistosoma mansoni cathepsin S (C01 family) 0.0015 0.0081 0.0081
Echinococcus granulosus geminin 0.0122 0.1735 0.1735
Brugia malayi Cathepsin L-like precursor 0.0047 0.0582 0.0829
Echinococcus multilocularis GPCR, family 2 0.0028 0.0281 0.0281
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0678 0.0678
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0252 0.3745 0.9449
Brugia malayi fibroinase precursor 0.0015 0.0081 0.0115
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0133 0.0133
Leishmania major AMP deaminase, putative 0.0083 0.1132 0.2781
Plasmodium vivax vivapain-3 0.0028 0.0284 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0083 0.1132 0.2781
Loa Loa (eye worm) MH2 domain-containing protein 0.0086 0.1179 0.1681
Echinococcus granulosus GPCR family 2 0.0028 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0115 0.1631 0.2325
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0027 0.0278 0.0599
Giardia lamblia Cathepsin L precursor 0.0015 0.0081 0.0667
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0207 0.042
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0027 0.0278 0.0701
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0284 0.0405
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0678 0.1616
Trypanosoma cruzi AMP deaminase 2, putative 0.0083 0.1132 0.2781
Echinococcus granulosus cathepsin L cysteine proteinase 0.0047 0.0582 0.0582
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0015 0.0081 0.0097
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0134 0.0197
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Loa Loa (eye worm) hypothetical protein 0.0172 0.2499 0.3563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0081 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0015 0.0081 0.0097
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0582 0.0582
Plasmodium falciparum serine repeat antigen 8 0.0015 0.0081 0.0204
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0792 0.113
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0792 0.0792
Onchocerca volvulus 0.0047 0.0582 0.1355
Echinococcus granulosus adenosine deaminase 0.0255 0.3777 0.3777
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0645 0.0919
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Brugia malayi hypothetical protein 0.0012 0.0035 0.005
Entamoeba histolytica cysteine protease, putative 0.0015 0.0081 0.0097
Echinococcus granulosus cathepsin l1 0.0034 0.0379 0.0379
Echinococcus granulosus cathepsin L 0.0028 0.0284 0.0284
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0015 0.0081 0.0061
Onchocerca volvulus 0.0083 0.1132 0.2844
Plasmodium falciparum serine repeat antigen 1 0.0015 0.0081 0.0204
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0027 0.0278 0.0396
Trypanosoma cruzi AMP deaminase, putative 0.0083 0.1132 0.2781
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0047 0.0582 0.0582
Brugia malayi cathepsin B-like cysteine proteinase 0.0252 0.3745 0.5338
Plasmodium falciparum adenosine deaminase 0.0255 0.3777 0.9537
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0134 0.0339
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.000000000066352 0.00000000016752
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0207 0.0207
Echinococcus multilocularis cysteine protease 0.0047 0.0582 0.0582
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0284 0.0615
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0949 0.1352
Brugia malayi cathepsin Z-like cysteine proteinase 0.0015 0.0081 0.0115
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.009 0.0228
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0081 0.0081
Giardia lamblia Hypothetical protein 0.0015 0.0081 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0081 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0134 0.0339
Giardia lamblia Cathepsin L precursor 0.0015 0.0081 0.0667
Echinococcus multilocularis AMP deaminase 2 0.0083 0.1132 0.1132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Echinococcus multilocularis microtubule associated protein 2 0.0658 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.3102 0.3102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Schistosoma mansoni cathepsin s 0.0013 0.0057 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0776 0.1107
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0047 0.0582 0.0829
Onchocerca volvulus 0.0047 0.0582 0.1355
Loa Loa (eye worm) hypothetical protein 0.0015 0.0081 0.0115
Schistosoma mansoni adenosylhomocysteinase 0.0165 0.2395 0.2395
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0015 0.0081 0.0061
Echinococcus granulosus cathepsin b 0.0252 0.3745 0.3745
Giardia lamblia Cathepsin B precursor 0.0088 0.1214 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0207 0.042
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0281 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0081 0.0097
Entamoeba histolytica adenosylhomocysteinase, putative 0.0266 0.3961 1
Echinococcus multilocularis cysteine protease 0.0047 0.0582 0.0582
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0015 0.0081 0.0081
Plasmodium falciparum adenosylhomocysteinase 0.0266 0.3961 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Echinococcus granulosus bloom syndrome protein 0.0023 0.0207 0.0207
Echinococcus granulosus cathepsin L 0.0015 0.0081 0.0081
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0027 0.0278 0.0396
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0284 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0015 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0582 0.1375
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0027 0.0278 0.0599
Loa Loa (eye worm) hypothetical protein 0.0053 0.0678 0.0967
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0015 0.0081 0.0081
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0379 0.054
Loa Loa (eye worm) ctsf protein 0.0047 0.0582 0.0829
Plasmodium falciparum serine repeat antigen 6 0.0015 0.0081 0.0204
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0792 0.0792
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0266 0.3961 1
Entamoeba histolytica AMP deaminase, putative 0.0083 0.1132 0.2781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0284 0.0615
Brugia malayi RNA binding protein 0.0071 0.0949 0.1352
Giardia lamblia Cathepsin B precursor 0.0015 0.0081 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0081 0.0097
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0266 0.3961 1
Schistosoma mansoni hypothetical protein 0.0028 0.0281 0.0281
Plasmodium falciparum serine repeat antigen 9 0.0015 0.0081 0.0204
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Echinococcus multilocularis geminin 0.0122 0.1735 0.1735
Entamoeba histolytica cysteine protease, putative 0.0015 0.0081 0.0097
Echinococcus multilocularis adenosine deaminase 0.0255 0.3777 0.3777
Plasmodium vivax serine-repeat antigen (SERA) 0.0015 0.0081 0.0061
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0047 0.0582 0.1469
Loa Loa (eye worm) fibroinase 0.0047 0.0582 0.0829
Loa Loa (eye worm) hypothetical protein 0.0018 0.0134 0.0191
Leishmania major hypothetical protein, conserved 0.0018 0.0134 0.0233
Schistosoma mansoni hypothetical protein 0.0122 0.1735 0.1735
Schistosoma mansoni adenosine deaminase-related 0.0255 0.3777 0.3777
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0047 0.0582 0.1375
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0088 0.1214 0.299
Trypanosoma cruzi AMP deaminase, putative 0.0083 0.1132 0.2781
Entamoeba histolytica adenosine deaminase, putative 0.0255 0.3777 0.9532
Leishmania major S-adenosylhomocysteine hydrolase 0.0266 0.3961 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0034 0.0379 0.0857
Brugia malayi Cathepsin L-like precursor 0.0034 0.0379 0.054
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0093 0.0091
Entamoeba histolytica cysteine protease, putative 0.0015 0.0081 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0015 0.0081 0.0097
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0284 0.0615
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0678 0.0678
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0678 0.0678
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0027 0.0278 0.0396
Brugia malayi Muscleblind-like protein 0.0465 0.7015 1
Schistosoma mansoni AMP deaminase 0.0083 0.1132 0.1132
Loa Loa (eye worm) cysteine protease 0.0047 0.0582 0.0829
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0284 0.0405
Loa Loa (eye worm) hypothetical protein 0.006 0.0776 0.1107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0281 0.0281
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0015 0.0081 0.0204
Plasmodium falciparum serine repeat antigen 7 0.0015 0.0081 0.0204
Brugia malayi Cathepsin L-like precursor 0.0047 0.0582 0.0829
Entamoeba histolytica cysteine protease, putative 0.0028 0.0284 0.0615
Echinococcus granulosus AMP deaminase 2 0.0083 0.1132 0.1132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0047 0.0582 0.1375
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0284 0.0615
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0792 0.0792
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0083 0.1132 0.2781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0081 0.0097
Leishmania major cathepsin L-like protease 0.0047 0.0582 0.1375
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0949 0.0949
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0134 0.0339
Brugia malayi MH2 domain containing protein 0.0086 0.1179 0.1681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0284 0.0615
Brugia malayi cathepsin L precursor 0.0015 0.0081 0.0115
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0081 0.0115
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0047 0.0582 0.1469
Trypanosoma cruzi AMP deaminase, putative 0.0083 0.1132 0.2781
Giardia lamblia Cathepsin L-like protease 0.0015 0.0081 0.0667
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0088 0.1214 0.299
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0281 0.0401
Toxoplasma gondii cathepsin CPC1 0.0015 0.0081 0.0204
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0949 0.1352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0582 0.1375
Brugia malayi cathepsin Z-like cysteine proteinase 0.0015 0.0081 0.0115
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.3102 0.3102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0252 0.3745 0.3745
Giardia lamblia Cathepsin B precursor 0.0015 0.0081 0.0667

Activities

Activity type Activity value Assay description Source Reference
LD50 (functional) = 0.261 mM kg-1 Tested in mouse for significant protection against the lethal effects of 2xLD50 of soman without atropine. ChEMBL. 2913310
LD50 (functional) = 0.261 mM kg-1 Tested in mouse for significant protection against the lethal effects of 2xLD50 of soman without atropine. ChEMBL. 2913310
logD (ADMET) = -1.2 Partition coefficient (logD7.6) ChEMBL. 2913310
pKa = 8.01 Dissociation constant (pKa) (in 0.1 M phosphate buffer) ChEMBL. 2913310
Survivors (functional) = 0 Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/4 LD50 of 2-PAM. ChEMBL. 2913310
Survivors (functional) = 0 Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/16 LD50 of 2-PAM. ChEMBL. 2913310
Survivors (functional) = 2 Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/8 LD50 of 2-PAM. ChEMBL. 2913310

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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