Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0592 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0592 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0592 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0101 | 0.002 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0101 | 0.002 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0101 | 0.002 | 0.5 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Schistosoma mansoni | adenosine kinase | 0.0101 | 0.002 | 0.002 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.01 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.01 | 0 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.0101 | 0.002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0592 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.01 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0592 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0101 | 0.002 | 0.002 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0101 | 0.002 | 0.5 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.002 | 0.002 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.01 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.01 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0592 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0101 | 0.002 | 0.5 |
Echinococcus multilocularis | adenosine kinase | 0.0101 | 0.002 | 0.002 |
Echinococcus granulosus | acetylcholinesterase | 0.0592 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0592 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0592 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0592 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Echinococcus granulosus | adenosine kinase | 0.0101 | 0.002 | 0.002 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0592 | 1 | 1 |
Onchocerca volvulus | 0.01 | 0 | 0.5 | |
Brugia malayi | Adenosine kinase-like | 0.0101 | 0.002 | 0.002 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0592 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.1 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 12.5 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 1.2 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 3.1 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 1.4 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 6.2 ug/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 2 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 25 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 3 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 50 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 1.1 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 12.5 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 1.2 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 3.1 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 1.4 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 6.2 ug/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 2 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 25 microg/mL) | ChEMBL. | 6779008 |
Activity (functional) | = 3 | Compound is evaluated for lamda-phage induction activity in Escherichia coli (dose at 50 microg/mL) | ChEMBL. | 6779008 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.