Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0629 | 0.7093 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0309 | 0.2907 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0629 | 0.7093 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1072 | 0.1512 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0629 | 0.7093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0542 | 0.5961 | 0.8404 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0629 | 0.7093 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0629 | 0.7093 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Schistosoma mansoni | immunophilin | 0.0629 | 0.7093 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0087 | 0 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0629 | 0.7093 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0629 | 0.7093 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0542 | 0.5961 | 0.8404 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0629 | 0.7093 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0629 | 0.7093 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0629 | 0.7093 | 1 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Echinococcus granulosus | geminin | 0.0169 | 0.1072 | 0.1512 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0309 | 0.2907 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0629 | 0.7093 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0087 | 0 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0629 | 0.7093 | 1 |
Schistosoma mansoni | immunophilin | 0.0542 | 0.5961 | 0.8404 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.1072 | 0.1512 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0087 | 0 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0629 | 0.7093 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0629 | 0.7093 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0629 | 0.7093 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0629 | 0.7093 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0629 | 0.7093 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0629 | 0.7093 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.1072 | 0.1512 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0629 | 0.7093 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0629 | 0.7093 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0542 | 0.5961 | 0.8404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8.1 uM | Anti-viral activity against HIV-1 in human PBM cells | ChEMBL. | 12383014 |
IC50 (ADMET) | > 100 uM | In vitro cytotoxicity against human peripheral blood mononuclear(PBM) cells | ChEMBL. | 12383014 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against CEM cells | ChEMBL. | 12383014 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against Vero cells | ChEMBL. | 12383014 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against CEM cells | ChEMBL. | 12383014 |
k cat (binding) | = 0.94 s-1 | Kinetic parameter Kcat of compound used as substrate for Adenosine deaminase was evaluated | ChEMBL. | 12383014 |
k cat (binding) | = 0.94 s-1 | Kinetic parameter Kcat of compound used as substrate for Adenosine deaminase was evaluated | ChEMBL. | 12383014 |
k cat/Km (binding) | = 0.05 uM-1 s-1 | Ratio of kinetic parameter Kcat to that of binding affinity towards adenosine deaminase KM. | ChEMBL. | 12383014 |
Km (binding) | = 18.3 uM | Binding efficiency towards mammalian Adenosine deaminase from calf intestinal mucosa | ChEMBL. | 12383014 |
Km (binding) | = 18.3 uM | Binding efficiency towards mammalian Adenosine deaminase from calf intestinal mucosa | ChEMBL. | 12383014 |
T1/2 (ADMET) | = 33 min | Half life value of the compound | ChEMBL. | 12383014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.