Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0394 | 0.3013 | 0.3013 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0297 | 0.1706 | 0.6016 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.021 | 0.0536 | 0.0536 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0366 | 0.263 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0366 | 0.263 | 0.263 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0366 | 0.263 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1706 | 0.6485 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0366 | 0.263 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0366 | 0.263 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0912 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.1706 | 0.6016 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0297 | 0.1706 | 0.6485 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0214 | 0.0581 | 0.0581 |
Echinococcus granulosus | geminin | 0.0194 | 0.031 | 0.031 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0366 | 0.263 | 0.263 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0297 | 0.1706 | 0.1706 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.1706 | 0.6016 |
Schistosoma mansoni | apoptosis regulator bax | 0.0297 | 0.1706 | 0.6016 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0366 | 0.263 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0297 | 0.1706 | 0.6016 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0366 | 0.263 | 1 |
Echinococcus multilocularis | geminin | 0.0194 | 0.031 | 0.031 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0394 | 0.3013 | 0.3013 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0184 | 0.0172 | 0.0172 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0184 | 0.0172 | 0.0172 |
Leishmania major | 0.0366 | 0.263 | 0.5 | |
Toxoplasma gondii | fructose-bisphospatase II | 0.0366 | 0.263 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0214 | 0.0581 | 0.0581 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0297 | 0.1706 | 0.6485 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0273 | 0.1378 | 0.4604 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0297 | 0.1706 | 0.1706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 68.8 mg kg-1 | Ability to reinduce anesthesia in mice as a measure of in vivo sedative-hypnotic activity | ChEMBL. | 7241505 |
ED50 (functional) | = 68.8 mg kg-1 | Ability to reinduce anesthesia in mice as a measure of in vivo sedative-hypnotic activity | ChEMBL. | 7241505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.