Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.0407 | 0.0407 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0108 | 0.0626 | 0.0228 |
Brugia malayi | Animal haem peroxidase family protein | 0.0431 | 0.6271 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.1274 | 0.0691 |
Brugia malayi | Animal haem peroxidase family protein | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0431 | 0.6271 | 1 |
Brugia malayi | Peroxidasin | 0.0431 | 0.6271 | 1 |
Onchocerca volvulus | 0.0431 | 0.6271 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Schistosoma mansoni | peroxidasin | 0.0431 | 0.6271 | 0.6022 |
Echinococcus multilocularis | peroxidasin | 0.0431 | 0.6271 | 0.6271 |
Onchocerca volvulus | Peroxidase homolog | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0108 | 0.0626 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0431 | 0.6271 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0645 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0106 | 0.0588 | 0.0188 |
Schistosoma mansoni | lipoxygenase | 0.0451 | 0.6613 | 0.6387 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0108 | 0.0626 | 0.0228 |
Onchocerca volvulus | Peroxidasin homolog | 0.0431 | 0.6271 | 1 |
Echinococcus granulosus | peroxidasin | 0.0431 | 0.6271 | 0.6113 |
Onchocerca volvulus | 0.0431 | 0.6271 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0108 | 0.0626 | 0.0626 |
Brugia malayi | Animal haem peroxidase family protein | 0.0431 | 0.6271 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0106 | 0.0588 | 0.0588 |
Schistosoma mansoni | lipoxygenase | 0.0645 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0431 | 0.6271 | 1 |
Echinococcus granulosus | RUN | 0.0108 | 0.0626 | 0.0228 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0108 | 0.0626 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0108 | 0.0626 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0167 | 0.1663 | 0.1309 |
Onchocerca volvulus | Peroxidasin homolog | 0.0431 | 0.6271 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0108 | 0.0626 | 0.0626 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0167 | 0.1663 | 0.1663 |
Onchocerca volvulus | Dual oxidase homolog | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Brugia malayi | hypothetical protein | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0431 | 0.6271 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0431 | 0.6271 | 1 |
Onchocerca volvulus | 0.0431 | 0.6271 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0431 | 0.6271 | 1 |
Schistosoma mansoni | peroxidasin | 0.0431 | 0.6271 | 0.6022 |
Echinococcus multilocularis | RUN | 0.0108 | 0.0626 | 0.0626 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0431 | 0.6271 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0108 | 0.0626 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.6271 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.01 uM | In vitro binding assay for the displacement of [3H]-MDL-105,519 from the glycine-site of NMDA receptors | ChEMBL. | 9871605 |
IC50 (binding) | = 0.01 uM | In vitro binding assay for the displacement of [3H]-MDL-105,519 from the glycine-site of NMDA receptors | ChEMBL. | 9871605 |
IC50 (binding) | ~ 10 uM | In vitro binding assay for the displacement of [3H]-AMPA from AMPA receptor | ChEMBL. | 9871605 |
IC50 (binding) | ~ 10 uM | In vitro binding assay for the displacement of [3H]-AMPA from AMPA receptor | ChEMBL. | 9871605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.