Detailed information for compound 252665

Basic information

Technical information
  • TDR Targets ID: 252665
  • Name: 3-methylacridin-9-amine
  • MW: 208.258 | Formula: C14H12N2
  • H donors: 1 H acceptors: 1 LogP: 3.21 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)nc1c(c2N)cccc1
  • InChi: 1S/C14H12N2/c1-9-6-7-11-13(8-9)16-12-5-3-2-4-10(12)14(11)15/h2-8H,1H3,(H2,15,16)
  • InChiKey: YDNFAUYKNHHSDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methyl-9-acridinamine
  • (3-methylacridin-9-yl)amine
  • 23045-13-8
  • BRN 0159422
  • 4-21-00-04256 (Beilstein Handbook Reference)
  • 5-Amino-2-methylacridine (European)
  • ACRIDINE, 9-AMINO-3-METHYL-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0231 0.024 0.024
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.045 0.0734 0.0734
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4488 0.9826 0.9706
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0231 0.024 0.024
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0231 0.024 0.024
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0231 0.024 0.024
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0382 0.058 0.058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.056 0.0982 0.0982
Echinococcus granulosus glycine receptor subunit alpha 1 0.0231 0.024 0.024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0231 0.024 0.3265
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.4488 0.9826 0.9826
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0231 0.024 0.024
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0231 0.024 0.024
Brugia malayi Cation transporter family protein 0.0231 0.024 0.3265
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4488 0.9826 0.9706
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0231 0.024 0.024
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0231 0.024 0.024
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.045 0.0734 0.0734
Echinococcus granulosus glycine receptor subunit beta 0.0231 0.024 0.024
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0231 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0231 0.024 0.024
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0231 0.024 0.3265
Loa Loa (eye worm) hypothetical protein 0.0382 0.058 0.058
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Giardia lamblia Hypothetical protein 0.2694 0.5787 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.045 0.0734 0.0734
Echinococcus granulosus glycine receptor subunit alpha 1 0.0231 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Onchocerca volvulus 0.045 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Echinococcus multilocularis glycine receptor subunit beta 0.0231 0.024 0.024
Echinococcus granulosus glycine receptor subunit alpha 1 0.0231 0.024 0.024
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0231 0.024 0.024
Brugia malayi Cation transporter family protein 0.045 0.0734 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0231 0.024 0.3265
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0231 0.024 0.3265
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4565 1 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) LGC-31 protein 0.0231 0.024 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0231 0.024 0.3265
Brugia malayi Cation transporter family protein 0.0231 0.024 0.3265
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0231 0.024 0.3265
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0231 0.024 0.024
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0231 0.024 0.3265
Onchocerca volvulus Putative nachr subunit 0.0382 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.2617 0.5613 0.5613
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0344 0.0495 0.0495
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0231 0.024 0.024
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4565 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0231 0.024 0.3265
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0382 0.058 0.058
Giardia lamblia Hypothetical protein 0.2694 0.5787 0.5
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.2694 0.5787 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0231 0.024 0.024
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0231 0.024 0.3265
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0231 0.024 0.3265
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Schistosoma mansoni 6-phosphofructokinase 0.4565 1 1
Onchocerca volvulus 0.0231 0.024 0.024
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4565 1 1
Loa Loa (eye worm) ACC-1 protein 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.045 0.0734 0.0734
Onchocerca volvulus 0.4565 1 1
Echinococcus granulosus nAChR subunit 0.0231 0.024 0.024
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0231 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Loa Loa (eye worm) ACC-1 protein 0.0231 0.024 0.024
Onchocerca volvulus 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.4565 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0231 0.024 0.3265
Brugia malayi excitatory GABA receptor EXP-1A 0.0231 0.024 0.3265
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0382 0.058 0.058
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0231 0.024 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0231 0.024 0.3265
Echinococcus multilocularis nAChR subunit 0.0231 0.024 0.024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0231 0.024 0.3265
Onchocerca volvulus 0.045 0.0734 0.0734
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0231 0.024 0.3265
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.2694 0.5787 0.5
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0231 0.024 0.024
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0382 0.058 0.058
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.4565 1 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0382 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.4565 1 1
Mycobacterium ulcerans hypothetical protein 0.2694 0.5787 0.5
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0231 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Echinococcus multilocularis glycine receptor subunit beta 0.0231 0.024 0.024
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.4488 0.9826 0.9706
Onchocerca volvulus 0.045 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.4488 0.9826 0.9706
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0382 0.058 0.058
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0231 0.024 0.024
Echinococcus granulosus tm gpcr rhodopsin 0.056 0.0982 0.0982
Echinococcus multilocularis expressed protein 0.0361 0.0532 0.0532
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0231 0.024 0.3265
Onchocerca volvulus 0.0231 0.024 0.024
Echinococcus granulosus expressed protein 0.0361 0.0532 0.0532
Schistosoma mansoni nAChR subunit 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0231 0.024 0.024
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0382 0.058 0.7903
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0382 0.058 0.058

Activities

Activity type Activity value Assay description Source Reference
Minimal bacteriostatic concentration (functional) 0 Minimal bacteriostatic concentration against streptococcus pyogenes under conditions of pH 7.3, 37 degree C; 1 in 160000 ChEMBL. 6979630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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