Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0231 | 0.024 | 0.3265 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0231 | 0.024 | 0.3265 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0231 | 0.024 | 0.3265 |
Giardia lamblia | Hypothetical protein | 0.2694 | 0.5787 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4488 | 0.9826 | 0.9706 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0231 | 0.024 | 0.3265 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0231 | 0.024 | 0.3265 |
Brugia malayi | Cation transporter family protein | 0.0231 | 0.024 | 0.3265 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0231 | 0.024 | 0.024 |
Onchocerca volvulus | 0.0231 | 0.024 | 0.024 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0382 | 0.058 | 0.058 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0231 | 0.024 | 0.024 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0382 | 0.058 | 0.7903 |
Onchocerca volvulus | 0.0231 | 0.024 | 0.024 | |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4488 | 0.9826 | 0.9706 |
Echinococcus multilocularis | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0382 | 0.058 | 0.058 |
Loa Loa (eye worm) | ACC-1 protein | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0231 | 0.024 | 0.024 |
Brugia malayi | Cation transporter family protein | 0.045 | 0.0734 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0382 | 0.058 | 0.058 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0231 | 0.024 | 0.3265 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0231 | 0.024 | 0.024 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4565 | 1 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0231 | 0.024 | 0.3265 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0231 | 0.024 | 0.3265 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2694 | 0.5787 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4565 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0231 | 0.024 | 0.3265 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0231 | 0.024 | 0.024 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0382 | 0.058 | 0.058 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2694 | 0.5787 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0382 | 0.058 | 0.058 |
Brugia malayi | Cation transporter family protein | 0.0231 | 0.024 | 0.3265 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0231 | 0.024 | 0.3265 |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0231 | 0.024 | 0.3265 |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.0734 | 0.0734 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4488 | 0.9826 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.045 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Onchocerca volvulus | 0.0231 | 0.024 | 0.024 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Echinococcus multilocularis | expressed protein | 0.0361 | 0.0532 | 0.0532 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4565 | 1 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.056 | 0.0982 | 0.0982 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0231 | 0.024 | 0.3265 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0382 | 0.058 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0231 | 0.024 | 0.024 |
Mycobacterium ulcerans | hypothetical protein | 0.2694 | 0.5787 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4488 | 0.9826 | 0.9706 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0382 | 0.058 | 0.058 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0231 | 0.024 | 0.024 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0231 | 0.024 | 0.3265 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0231 | 0.024 | 0.024 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0231 | 0.024 | 0.024 |
Onchocerca volvulus | 0.4565 | 1 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4565 | 1 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0231 | 0.024 | 0.024 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0231 | 0.024 | 0.3265 |
Schistosoma mansoni | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Onchocerca volvulus | 0.045 | 0.0734 | 0.0734 | |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.056 | 0.0982 | 0.0982 |
Onchocerca volvulus | 0.045 | 0.0734 | 0.0734 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0231 | 0.024 | 0.3265 |
Echinococcus granulosus | expressed protein | 0.0361 | 0.0532 | 0.0532 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4565 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0231 | 0.024 | 0.024 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.058 | 0.058 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.4565 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.045 | 0.0734 | 0.0734 |
Echinococcus granulosus | nAChR subunit | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | ACC-1 protein | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | LGC-31 protein | 0.0231 | 0.024 | 0.024 |
Giardia lamblia | Hypothetical protein | 0.2694 | 0.5787 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0382 | 0.058 | 0.058 |
Onchocerca volvulus | 0.045 | 0.0734 | 0.0734 | |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.045 | 0.0734 | 0.0734 |
Loa Loa (eye worm) | hypothetical protein | 0.4488 | 0.9826 | 0.9826 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.0495 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0231 | 0.024 | 0.3265 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.2617 | 0.5613 | 0.5613 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Minimal bacteriostatic concentration (functional) | 0 | Minimal bacteriostatic concentration against streptococcus pyogenes under conditions of pH 7.3, 37 degree C; 1 in 160000 | ChEMBL. | 6979630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.