Detailed information for compound 252692

Basic information

Technical information
  • TDR Targets ID: 252692
  • Name: 4,7-dimethoxy-2-(4-methoxyphenyl)-1H-indole-3 -carbaldehyde
  • MW: 311.332 | Formula: C18H17NO4
  • H donors: 1 H acceptors: 1 LogP: 3.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1[nH]c2c(c1C=O)c(OC)ccc2OC
  • InChi: 1S/C18H17NO4/c1-21-12-6-4-11(5-7-12)17-13(10-20)16-14(22-2)8-9-15(23-3)18(16)19-17/h4-10,19H,1-3H3
  • InChiKey: UQVKRTDKGBROKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,7-dimethoxy-2-(4-methoxyphenyl)-1H-indole-3-carboxaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0055 0.0083
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0116 0.0628 0.1127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0429 0.0797
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0009 0.001 0.0007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.001 0.0017 0.0034
Onchocerca volvulus Fatty acid synthase homolog 0.0022 0.0088 0.0136
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0009 0.001 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0429 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Leishmania major GTP-binding protein, putative 0.0023 0.0094 0.0524
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0375 0.2288
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0136 0.0245
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0108
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0287 0.1606 0.3019
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Leishmania major hypothetical protein, conserved 0.0045 0.0219 0.1308
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0107 0.0666
Mycobacterium ulcerans Type I modular polyketide synthase 0.0012 0.0031 0.0077
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0095 0.0534
Treponema pallidum sodium- and chloride- dependent transporter 0.0611 0.3468 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0181 0.0299
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0016 0.0054 0.0138
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0181 0.0331
Trypanosoma brucei glycerol uptake protein, putative 0.0009 0.0013 0.0016
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0104 0.0556 0.1038
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0009 0.001 0.0012
Schistosoma mansoni zinc finger protein 0.0009 0.0013 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0094 0.0582
Schistosoma mansoni alpha-glucosidase 0.0148 0.0809 0.1516
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.0429 0.0797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0429 0.0797
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0069 0.038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0021
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0095 0.1015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0012 0.0031 0.003
Echinococcus granulosus serotonin transporter 0.0611 0.3468 0.6535
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0024 0.0025
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0095 0.0534
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0104 0.0556 0.1038
Echinococcus granulosus sterol O acyltransferase 1 0.0093 0.0494 0.092
Toxoplasma gondii ABC1 family protein 0.0023 0.0094 0.058
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0069 0.0119
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.0897 0.1619
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0378
Onchocerca volvulus 0.0241 0.1343 0.2327
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0009 0.0013 0.0012
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Brugia malayi Cathepsin L-like precursor 0.0013 0.0033 0.0043
Brugia malayi hypothetical protein 0.0116 0.0628 0.1127
Treponema pallidum exodeoxyribonuclease (exoA) 0.0009 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0378
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0031 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0055 0.0151
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0163 0.0897 0.1619
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.0429 0.0764
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0013 0.0033 0.0177
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0009 0.0014 0.0025
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0017 0.0059 0.0306
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.0429 0.0797
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0181 0.0313
Brugia malayi CXXC zinc finger family protein 0.0013 0.0034 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0094 0.0529
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0009 0.0014 0.0012
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0852 0.1596
Loa Loa (eye worm) hypothetical protein 0.0163 0.0897 0.1634
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0252 0.1407 0.255
Leishmania major glycerol uptake protein, putative 0.0009 0.0013 0.0016
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.061 0.3461 0.6303
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0252 0.1407 0.255
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0009 0.001 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0009 0.0014 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0009 0.0014 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Entamoeba histolytica hypothetical protein 0.0044 0.0214 0.2437
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Brugia malayi Cell division protein kinase 2 0.0009 0.0014 0.0007
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0009 0.0014 0.0023
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.061 0.3461 0.6297
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0069 0.0104
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0095 0.081
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0116 0.0628 0.1143
Giardia lamblia PHD finger protein 15 0.0015 0.0047 0.0439
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0069 0.0119
Plasmodium falciparum cysteine proteinase falcipain 1 0.001 0.0016 0.0031
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0009 0.0013 0.0023
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0009 0.0014 0.0025
Brugia malayi steroid hormone receptor 0.0082 0.0429 0.0764
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.0429 0.0797
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0252 0.1407 0.2645
Plasmodium falciparum transporter, putative 0.0104 0.0556 0.3599
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0009 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Echinococcus multilocularis carbonic anhydrase II 0.0287 0.1606 0.3019
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0009 0.0014 0.0014
Trypanosoma brucei glucosidase, putative 0.0038 0.0179 0.1061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi hypothetical protein 0.0038 0.0181 0.0313
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.061 0.3461 0.6521
Schistosoma mansoni sodium/chloride dependent transporter 0.0104 0.0558 0.1042
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Trypanosoma cruzi DNA repair protein, putative 0.0017 0.0059 0.0306
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0136 0.0245
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0082 0.0429 0.0797
Schistosoma mansoni alpha-glucosidase 0.0148 0.0809 0.1516
Mycobacterium tuberculosis Probable lipase LipE 0.0023 0.0094 0.0094
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.001 0.0019 0.004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0181 0.0331
Schistosoma mansoni ap endonuclease 0.0009 0.0014 0.0016
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0013 0.0035 0.0035
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0009 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0023 0.009 0.05
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Giardia lamblia Kinase, CAMK CAMKL 0.0009 0.0014 0.0043
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0009 0.001 0.0012
Echinococcus granulosus muscleblind protein 0.0155 0.0852 0.1596
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0151
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0023 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0009 0.0014 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.0996
Loa Loa (eye worm) CYP4Cod1 0.001 0.0018 0.0033
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.061 0.3461 0.6521
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0009 0.0014 0.0028
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0082 0.0429 0.0797
Brugia malayi Blistered cuticle protein 3 0.0023 0.009 0.0146
Mycobacterium ulcerans aldehyde dehydrogenase 0.0157 0.086 0.262
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.0429 0.0797
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0339 0.2062
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Loa Loa (eye worm) hypothetical protein 0.0611 0.3468 0.6317
Echinococcus multilocularis cyclin dependent kinase 9 0.0009 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0042 0.0201
Echinococcus granulosus glycine receptor subunit alpha 1 0.0252 0.1407 0.2645
Echinococcus granulosus serine:threonine protein kinase NLK 0.0009 0.0014 0.0014
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0069 0.0119
Brugia malayi tailless protein 0.0038 0.0181 0.0313
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0172
Brugia malayi Importin beta-1 subunit 0.0032 0.0141 0.024
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0179 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0044 0.0214 0.0393
Leishmania major cathepsin L-like protease 0.0072 0.0375 0.2288
Leishmania major trypanothione reductase 0.0068 0.0349 0.2125
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0141 0.0891
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Onchocerca volvulus 0.0116 0.0628 0.1079
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Leishmania major hypothetical protein, conserved 0.0023 0.0094 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0114 0.0612 0.1145
Echinococcus multilocularis caspase 3 0.0348 0.1957 0.3683
Entamoeba histolytica hypothetical protein 0.0026 0.0107 0.1159
Schistosoma mansoni jumonji/arid domain-containing protein 0.0019 0.0069 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Brugia malayi hypothetical protein 0.0043 0.0208 0.0361
Schistosoma mansoni aldehyde dehydrogenase 0.0157 0.086 0.1612
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0008 0.0007 0.0003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0024 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Onchocerca volvulus 0.0099 0.0531 0.0909
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0011 0.0024 0.0078
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0287 0.1606 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.078 0.4439 0.8366
Loa Loa (eye worm) fatty acid synthase 0.0012 0.003 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0136 0.0245
Brugia malayi hypothetical protein 0.0116 0.0628 0.1127
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0013 0.0033 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0025 0.0106 0.0657
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0023
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0108
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0054 0.0054
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0009 0.001 0.0012
Schistosoma mansoni carbonic anhydrase 0.0163 0.0897 0.1682
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0556 0.3599
Schistosoma mansoni tar DNA-binding protein 0.0114 0.0612 0.1145
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0628 0.1127
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0069 0.0707
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0009 0.0013 0.0031
Brugia malayi hypothetical protein 0.0038 0.0181 0.0313
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0252 0.1407 0.2645
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0009 0.001 0.0009
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0009 0.001 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0107 0.0609
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0094 0.0542
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0013 0.0033 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0181 0.0313
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Brugia malayi hypothetical protein 0.0116 0.0628 0.1127
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0208 0.0361
Brugia malayi nuclear receptor RXR 0.0043 0.0208 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.002 0.0077 0.0134
Onchocerca volvulus Huntingtin homolog 0.0061 0.0312 0.0527
Echinococcus multilocularis caspase 2 0.0498 0.2819 0.5309
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0009 0.0014 0.0017
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0069 0.0119
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0252 0.1407 0.255
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0023 0.0094 0.0271
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0252 0.1407 0.255
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0011 0.0024 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.002 0.0077 0.0134
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0012 0.0031 0.003
Echinococcus granulosus cpg binding protein 0.0014 0.0038 0.006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0027 0.0027
Echinococcus granulosus snurportin 1 0.0337 0.1893 0.356
Plasmodium falciparum ataxin-2 like protein, putative 0.0045 0.0219 0.1369
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi RNA recognition motif domain containing protein 0.0114 0.0612 0.1099
Mycobacterium tuberculosis Probable reductase 0.0154 0.0847 0.0846
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Echinococcus granulosus FTZ F1 alpha 0.0082 0.0429 0.0797
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Onchocerca volvulus 0.0252 0.1407 0.244
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0018 0.0066 0.0065
Brugia malayi MBOAT family protein 0.0009 0.0013 0.0005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0181 0.0331
Onchocerca volvulus 0.0252 0.1407 0.244
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.061 0.3461 0.6521
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0011 0.0024 0.0023
Schistosoma mansoni hypothetical protein 0.002 0.0076 0.0133
Brugia malayi nuclear receptor NHR-88 0.0038 0.0181 0.0313
Echinococcus granulosus mitogen activated protein kinase 15 0.0009 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Echinococcus granulosus apoptotic protease activating factor 1 0.0226 0.1256 0.2359
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0252 0.1407 0.2563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Echinococcus granulosus cathepsin L 0.001 0.0016 0.002
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0287 0.1606 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0016 0.0054 0.0436
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0009 0.0014 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0031 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Leishmania major cytochrome p450-like protein 0.001 0.0018 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) haspin protein kinase 0.0009 0.0014 0.0025
Trypanosoma brucei glycerol uptake protein, putative 0.0009 0.0013 0.0016
Chlamydia trachomatis recombinase RecA 0.0056 0.028 0.2317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0044 0.0214 0.0393
Leishmania major glycerol uptake protein, putative 0.0009 0.0013 0.0016
Mycobacterium tuberculosis Conserved protein 0.0023 0.0094 0.0094
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0128 0.023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0095 0.0534
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Schistosoma mansoni serine/threonine kinase 0.0009 0.0014 0.0014
Loa Loa (eye worm) GABA receptor subunit 0.0136 0.074 0.1348
Echinococcus granulosus tar DNA binding protein 0.0114 0.0612 0.1145
Echinococcus multilocularis PHD finger protein rhinoceros 0.0015 0.0047 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1524 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0049 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0061
Schistosoma mansoni hypothetical protein 0.0163 0.0897 0.1682
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0157 0.086 0.5327
Plasmodium vivax vivapain-1 0.001 0.0016 0.0031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0012 0.0031 0.003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0154 0.0847 0.2526
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0055 0.0148
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Loa Loa (eye worm) LGC-31 protein 0.0252 0.1407 0.2563
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0009 0.0014 0.0053
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0094 0.0165
Leishmania major cathepsin L-like protease 0.0072 0.0375 0.2288
Trichomonas vaginalis transmembrane protein nessy, putative 0.0009 0.0013 0.0043
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0023 0.0094 0.0154
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0252 0.1407 0.2645
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0095 0.0587
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.3622
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0095 0.0168
Plasmodium falciparum ataxin-2 like protein, putative 0.0045 0.0219 0.1369
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0009 0.001 0.0024
Schistosoma mansoni acetylcholine receptor subunit beta 0.0116 0.0628 0.1174
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0172
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0179 0.2018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0157 0.086 0.262
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0009 0.001 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0114 0.0612 0.1145
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0179 0.1061
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0009 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0093 0.0494 0.0899
Echinococcus granulosus serine:threonine protein kinase haspin 0.0009 0.0012 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0141 0.0824
Entamoeba histolytica cysteine protease, putative 0.0019 0.0069 0.0707
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0069 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.0429 0.078
Mycobacterium ulcerans beta-lactamase 0.0023 0.0094 0.0271
Echinococcus multilocularis thioredoxin glutathione reductase 0.0068 0.0349 0.0647
Brugia malayi RNA, U transporter 1 0.009 0.0475 0.0849
Trypanosoma brucei carbonic anhydrase-like protein 0.0287 0.1606 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0009 0.0013 0.0012
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0016 0.0054 0.0053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0024 0.0033
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0009 0.0013 0.0012
Echinococcus granulosus PHD finger protein rhinoceros 0.0015 0.0047 0.0077
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0009 0.0014 0.0017
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0013 0.0033 0.0273
Echinococcus granulosus glycine receptor subunit alpha 1 0.0252 0.1407 0.2645
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0018 0.0033
Brugia malayi jmjC domain containing protein 0.0049 0.0243 0.0426
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0141 0.0256
Brugia malayi hypothetical protein 0.0009 0.0012 0.0003
Toxoplasma gondii cathepsin CPL 0.0019 0.0069 0.0415
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.001 0.0018 0.0037
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0013 0.0035 0.0035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0024 0.0033
Brugia malayi beta-lactamase 0.0023 0.0094 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi Hhat protein 0.0009 0.0013 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0074 0.0383 0.1133
Loa Loa (eye worm) hypothetical protein 0.0611 0.3468 0.6317
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0151 0.0826 0.9727
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0155 0.0849 1
Echinococcus multilocularis dnaJ subfamily B 0.0182 0.1006 0.1887
Echinococcus granulosus nAChR subunit 0.0136 0.074 0.1385
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.0429 0.0797
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Trypanosoma brucei Macro domain containing protein, putative 0.0009 0.0012 0.0011
Echinococcus granulosus caspase 0.062 0.3521 0.6633
Schistosoma mansoni nAChR subunit 0.0116 0.0628 0.1174
Loa Loa (eye worm) DR-78 0.0038 0.0181 0.033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0027 0.0027
Onchocerca volvulus Putative nachr subunit 0.061 0.3461 0.6025
Schistosoma mansoni protein kinase 0.0009 0.0014 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0019 0.0069 0.0119
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0016 0.002
Echinococcus multilocularis serotonin transporter 0.0611 0.3468 0.6535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0082 0.0429 0.078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.0429 0.078
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0252 0.1407 0.2645
Loa Loa (eye worm) hypothetical protein 0.0058 0.0293 0.0533
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0429 0.0797
Loa Loa (eye worm) hypothetical protein 0.061 0.3461 0.6303
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0031 0.0129
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0013 0.0033 0.0144
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0042 0.0201
Brugia malayi Bromodomain containing protein 0.0015 0.0047 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0429 0.0764
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0252 0.1407 0.2645
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0181 0.033
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0009 0.001 0.0024
Trypanosoma brucei Metacaspase-4 0.0272 0.1524 0.9485
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0009 0.0014 0.0053
Brugia malayi excitatory GABA receptor EXP-1A 0.0252 0.1407 0.255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0181 0.0331
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0252 0.1407 0.255
Brugia malayi diacylglycerol acyltransferase 0.0009 0.0013 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0179 0.1142
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.0106
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0116 0.0628 0.1143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.002 0.0077 0.0134
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0023 0.0094 0.0094
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0116 0.0628 0.1127
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0095 0.0551
Entamoeba histolytica hypothetical protein 0.0136 0.074 0.8698
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0252 0.1407 0.2645
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Brugia malayi Pre-SET motif family protein 0.0212 0.1175 0.2126
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1606 0.9175 0.9175
Treponema pallidum recombinase A 0.0056 0.028 0.0792
Echinococcus multilocularis carbonic anhydrase 0.0163 0.0897 0.1682
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0017 0.0055 0.0151
Brugia malayi hypothetical protein 0.0116 0.0628 0.1127
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0042 0.0237
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0095 0.0155
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0157 0.086 0.0859
Entamoeba histolytica hypothetical protein 0.0044 0.0214 0.2437
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0024 0.0033
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0252 0.1407 0.2563
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0018 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0172
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.0429 0.0797
Schistosoma mansoni caspase-3 (C14 family) 0.062 0.3521 0.6633
Onchocerca volvulus Dual oxidase homolog 0.0023 0.009 0.0139
Trypanosoma brucei metacaspase MCA3 0.0272 0.1524 0.9485
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0252 0.1407 0.2563
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0094 0.0524
Onchocerca volvulus 0.0252 0.1407 0.244
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.062 0.3521 0.6633
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0095 0.0534
Echinococcus granulosus caspase 3 0.0348 0.1957 0.3683
Onchocerca volvulus 0.0252 0.1407 0.244
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0009 0.0013 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0931 0.5305 1
Trypanosoma brucei metacaspase 0.0272 0.1524 0.9485
Loa Loa (eye worm) beta-lactamase 0.0023 0.0094 0.0172
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Onchocerca volvulus 0.0019 0.0069 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1524 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0008 0.0007 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0429 0.0764
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Onchocerca volvulus 0.0104 0.0556 0.0953
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0172 0.0946 0.0945
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0179 0.1061
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0287 0.1606 0.2912
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0136 0.0245
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0252 0.1407 0.2645
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0069 0.0372
Entamoeba histolytica cysteine proteinase 1, putative 0.001 0.0016 0.0078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0017 0.0058 0.0106
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0009 0.0013 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0009 0.001 0.0007
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0013 0.0033 0.0273
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.074 0.1332
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0252 0.1407 0.2645
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.0429 0.0797
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.0429 0.0797
Brugia malayi MBOAT family protein 0.0009 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Echinococcus multilocularis cysteine protease 0.0019 0.0069 0.0119
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0024 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0272 0.1524 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0069 0.038
Loa Loa (eye worm) hypothetical protein 0.0155 0.0852 0.1551
Echinococcus granulosus carbonic anhydrase II 0.0287 0.1606 0.3019
Loa Loa (eye worm) blistered cuticle protein 3 0.0023 0.009 0.0163
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0511 0.2894 0.545
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0154 0.0847 0.0846
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0009 0.0012 0.0038
Echinococcus multilocularis MACRO domain containing protein 2 0.0009 0.0012 0.0011
Onchocerca volvulus 0.0104 0.0556 0.0953
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0126 0.0685 0.4476
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0272 0.1524 0.2864
Mycobacterium ulcerans lipoprotein LppD 0.0009 0.0012 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0181 0.0331
Echinococcus granulosus carbonic anhydrase 0.0163 0.0897 0.1682
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0947 0.1775
Schistosoma mansoni ran 0.0023 0.0094 0.0165
Schistosoma mansoni nuclear receptor 0.0038 0.0181 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) TAR-binding protein 0.0114 0.0612 0.1115
Schistosoma mansoni acetylcholine receptor-related 0.0116 0.0628 0.1174
Schistosoma mansoni cpg binding protein 0.0013 0.0034 0.0052
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0012 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0628 0.1127
Brugia malayi Cytochrome P450 family protein 0.0015 0.0049 0.0071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0024 0.0033
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0018 0.0051
Loa Loa (eye worm) hypothetical protein 0.0155 0.0852 0.1551
Brugia malayi hypothetical protein 0.0043 0.0208 0.0361
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0375 0.2288
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0061
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0009 0.001 0.0009
Trypanosoma cruzi metacaspase, putative 0.0272 0.1524 0.9485
Echinococcus multilocularis cathepsin L 0.001 0.0016 0.002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0181 0.0331
Plasmodium vivax amine transporter, putative 0.0104 0.0556 0.3599
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Schistosoma mansoni nAChR subunit 0.0116 0.0628 0.1174
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0181 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0016 0.0054 0.0314
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0016 0.0041
Loa Loa (eye worm) haspin protein kinase 0.0009 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0009 0.001 0.0009
Schistosoma mansoni zinc finger protein 0.0038 0.0181 0.0331
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0181 0.0331
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0013 0.0035 0.0088
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0009 0.001 0.0012
Treponema pallidum fructose-bisphosphate aldolase 0.0151 0.0826 0.2369
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0018 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0013 0.0043
Treponema pallidum replicative DNA helicase (dnaB) 0.0199 0.1105 0.3175
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0009 0.0013 0.0023
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0009 0.0012 0.001
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0136 0.074 0.1332
Entamoeba histolytica hypothetical protein 0.0009 0.0012 0.0019
Trypanosoma cruzi GUP1, putative 0.0009 0.0013 0.0016
Onchocerca volvulus Cell death protein 3 homolog 0.0498 0.2819 0.4904
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.0996
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0179 0.2018
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0179 0.0327
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.0429 0.0797
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.0061
Echinococcus multilocularis caspase 0.062 0.3521 0.6633
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0016 0.0078
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0009 0.0014 0.0026
Loa Loa (eye worm) hhat protein 0.0009 0.0013 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0016 0.0054 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0136 0.0245
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0136 0.0245
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0016 0.0041
Leishmania major phosphopantetheinyl transferase-like protein 0.0016 0.0054 0.0276
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0429 0.0797
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0252 0.1407 0.255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0016 0.0069
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0009 0.001 0.0018
Mycobacterium tuberculosis Probable thioesterase TesA 0.001 0.0019 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0017 0.0058 0.0088
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0013 0.0033 0.0177
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0181 0.0331
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0013 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0045 0.0219 0.1308
Brugia malayi exodeoxyribonuclease III family protein 0.0009 0.0014 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0182 0.1006 0.1887
Schistosoma mansoni jumonji domain containing protein 0.0039 0.0185 0.0338
Mycobacterium ulcerans lipase LipD 0.0023 0.0094 0.0271
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Plasmodium vivax thioredoxin reductase, putative 0.0068 0.0349 0.2231
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0252 0.1407 0.2645
Onchocerca volvulus 0.0058 0.0293 0.0494
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0033 0.0177
Plasmodium falciparum glutathione reductase 0.0068 0.0349 0.2231
Trypanosoma brucei metacaspase 5, putative 0.0272 0.1524 0.9485
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0017 0.0059 0.009
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0095 0.0534
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0055 0.0148
Echinococcus granulosus L aminoadipate semialdehyde 0.0058 0.0293 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.002 0.0077 0.0134
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0181 0.0331
Entamoeba histolytica hypothetical protein 0.0044 0.0214 0.2437
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0199 0.1105 0.3372
Mycobacterium leprae Conserved hypothetical protein 0.0588 0.3336 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.0897 0.1619
Onchocerca volvulus 0.0013 0.0034 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0023 0.0094 0.0167
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0012 0.0031 0.0075
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.0429 0.078
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0009 0.001 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0069 0.0119
Brugia malayi Cation transporter family protein 0.0252 0.1407 0.255
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0009 0.0013 0.0012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0049 0.0243 0.0448
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0094 0.0542
Loa Loa (eye worm) acetylcholine receptor protein 0.0116 0.0628 0.1143
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0054 0.0279
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0074 0.0383 0.0383
Echinococcus multilocularis ubiquitin specific protease 41 0.0013 0.0033 0.0051
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0108
Echinococcus multilocularis MACRO domain containing protein 2 0.0009 0.0012 0.0011
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0095 0.0273
Echinococcus granulosus carbonic anhydrase 0.0163 0.0897 0.1682
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0094 0.0524
Onchocerca volvulus 0.0136 0.074 0.1274
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0116 0.0628 0.1174
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0023
Schistosoma mansoni ap endonuclease 0.0009 0.0014 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.002 0.0077 0.0134
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0181 0.0331
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0157 0.086 0.1612
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.1012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0009 0.0013 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0123 0.022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0049 0.0243 0.0448
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0154 0.0847 0.0846
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0024 0.0043
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0013 0.0035 0.009
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0199 0.1105 0.3301
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0611 0.3468 0.6535
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0069 0.0108
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0009 0.0012 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.0429 0.0764
Brugia malayi Protein kinase domain containing protein 0.0009 0.0014 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0095 0.0534
Echinococcus multilocularis lysine specific demethylase 5A 0.0018 0.0065 0.0111
Echinococcus granulosus peregrin 0.0015 0.0047 0.0077
Echinococcus granulosus nAChR subunit 0.0252 0.1407 0.2645
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.0429 0.0764
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.001
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0576 0.3265 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Leishmania major ferric reductase, putative 0.0023 0.009 0.05
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0042 0.0201
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0179 0.1142
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0011
Schistosoma mansoni sterol O-acyltransferase 1 0.0093 0.0494 0.092
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0033 0.0179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Mycobacterium tuberculosis Probable lipase LipD 0.0023 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0033 0.0278
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Onchocerca volvulus 0.0023 0.0094 0.0147
Plasmodium vivax ataxin-2 like protein, putative 0.0045 0.0219 0.1369
Mycobacterium leprae Probable lipase LipE 0.0023 0.0094 0.0265
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0094 0.0582
Loa Loa (eye worm) cysteine protease 0.0019 0.0069 0.0126
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0095 0.0551
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Schistosoma mansoni caspase-7 (C14 family) 0.062 0.3521 0.6633
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0286 0.1732
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0009 0.0013 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0179 0.1142
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.1175 0.214
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0057
Schistosoma mansoni neurotransmitter gated ion channel 0.0136 0.074 0.1385
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0181 0.0331
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0149 0.0816 0.0815
Onchocerca volvulus 0.0252 0.1407 0.244
Loa Loa (eye worm) hypothetical protein 0.0045 0.0219 0.0398
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0172 0.0946 0.0945
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0009 0.0011 0.0011
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0181 0.0313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0172 0.0946 0.2823
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0069 0.0104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0208 0.0381
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0009 0.0013 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0023 0.009 0.05
Plasmodium vivax metacaspase 1, putative 0.0272 0.1524 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Brugia malayi ecdysteroid receptor 0.0082 0.0429 0.0764
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0429 0.0764
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Trypanosoma cruzi metacaspase, putative 0.0272 0.1524 0.9485
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0136 0.074 0.1332
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0024 0.0033
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0252 0.1407 0.255
Entamoeba histolytica cell division protein kinase 2, putative 0.0009 0.0014 0.0043
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0009 0.0013 0.0012
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0009 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0179 0.1061
Brugia malayi Thioredoxin reductase 0.0068 0.0349 0.0619
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0016 0.002
Mycobacterium tuberculosis Conserved protein 0.0023 0.0094 0.0094
Echinococcus multilocularis sterol O acyltransferase 1 0.0093 0.0494 0.092
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1007 0.5738 1
Echinococcus granulosus jumonji domain containing protein 0.0021 0.0081 0.0141
Entamoeba histolytica hypothetical protein 0.0044 0.0214 0.2437
Trichomonas vaginalis CMGC family protein kinase 0.0009 0.0014 0.005
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.001 0.0017 0.0035
Echinococcus multilocularis tar DNA binding protein 0.0114 0.0612 0.1145
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0055 0.0083
Trypanosoma cruzi metacaspase, putative 0.0272 0.1524 0.9485
Echinococcus granulosus o acyltransferase membrane bound domain 0.0009 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0009 0.0014 0.005
Brugia malayi beta-lactamase family protein 0.0023 0.0094 0.0154
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0056 0.028 0.0823
Plasmodium falciparum thioredoxin reductase 0.0068 0.0349 0.2231
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0077
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0012 0.0022
Onchocerca volvulus 0.0116 0.0628 0.1079
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0094 0.0529
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0009 0.001 0.0007
Toxoplasma gondii hypothetical protein 0.0163 0.0897 0.5873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0027 0.0027
Onchocerca volvulus 0.0136 0.074 0.1274
Entamoeba histolytica hypothetical protein 0.0016 0.0054 0.0524
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0349 0.2125
Brugia malayi Cation transporter family protein 0.0252 0.1407 0.255
Plasmodium vivax SET domain protein, putative 0.0031 0.0136 0.0822
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0172
Echinococcus multilocularis apoptotic protease activating factor 1 0.0226 0.1256 0.2359
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0054 0.0144
Plasmodium falciparum metacaspase-like protein 0.0272 0.1524 1
Schistosoma mansoni aldehyde dehydrogenase 0.0009 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Echinococcus multilocularis sodium and chloride dependent glycine 0.0104 0.0556 0.1038
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0009 0.0014 0.005
Schistosoma mansoni cpg binding protein 0.0014 0.0038 0.006
Echinococcus granulosus MACRO domain containing protein 2 0.0009 0.0012 0.0011
Echinococcus multilocularis glycine receptor subunit beta 0.0252 0.1407 0.2645
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0042 0.0381
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0094 0.0265
Echinococcus granulosus o acyltransferase membrane bound domain 0.0009 0.0013 0.0012
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0009 0.001 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0054 0.0081
Toxoplasma gondii macro domain-containing protein 0.0009 0.0012 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0157 0.086 0.1612
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0252 0.1407 0.2563
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0012 0.0031 0.0077
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0011 0.0024 0.0078
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0009 0.001 0.0012
Trichomonas vaginalis ran, putative 0.0023 0.0094 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0082 0.0429 0.0764
Loa Loa (eye worm) thioredoxin reductase 0.0068 0.0349 0.0636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0016 0.0069
Plasmodium falciparum importin beta, putative 0.0032 0.0141 0.0858
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0009 0.0014 0.0014
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0094 0.0153
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0015 0.0047 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0042 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.0429 0.0797
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0009 0.001 0.0012
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0058 0.0293 0.0541
Trichomonas vaginalis set domain proteins, putative 0.0241 0.1343 0.8809
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0009 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0082 0.0429 0.0797
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0208 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.0429 0.078
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0095 0.0534
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0947 0.1709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Loa Loa (eye worm) CXXC zinc finger family protein 0.0013 0.0034 0.0062
Schistosoma mansoni hypothetical protein 0.0009 0.0013 0.0012
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0429 0.0797
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Echinococcus multilocularis caspase 8 0.0272 0.1524 0.2864
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.002 0.0077 0.0134
Brugia malayi hypothetical protein 0.0104 0.0556 0.0996
Mycobacterium ulcerans aldehyde dehydrogenase 0.0157 0.086 0.262
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0094 0.0576
Trypanosoma cruzi PAB1-binding protein , putative 0.0045 0.0219 0.1308
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0181 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0136 0.0245
Toxoplasma gondii PHD-finger domain-containing protein 0.0015 0.0047 0.0267
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0009 0.0013 0.0012
Onchocerca volvulus 0.0019 0.0069 0.0104
Schistosoma mansoni alpha glucosidase 0.0038 0.0179 0.0327
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0009 0.0012 0.001
Mycobacterium ulcerans Type I modular polyketide synthase 0.0012 0.0031 0.0077
Onchocerca volvulus 0.0611 0.3468 0.6038
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0009 0.0014 0.0023
Brugia malayi Cytochrome P450 family protein 0.001 0.0018 0.0015
Echinococcus granulosus cathepsin l1 0.0019 0.0069 0.0119
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0116 0.0628 0.1127
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Onchocerca volvulus 0.0226 0.1256 0.2175
Echinococcus granulosus glycine receptor subunit beta 0.0252 0.1407 0.2645
Mycobacterium tuberculosis Probable hydrolase 0.0023 0.0094 0.0094
Schistosoma mansoni neurotransmitter gated ion channel 0.0116 0.0628 0.1174
Brugia malayi beta-lactamase family protein 0.0023 0.0094 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1524 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0252 0.1407 0.255
Toxoplasma gondii hypothetical protein 0.0009 0.0013 0.0041
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0136 0.074 0.1332
Brugia malayi cyclin-dependent kinase 7 homolog 0.0009 0.0014 0.0007
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0012 0.0031 0.0075
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0033 0.0051
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0252 0.1407 0.2645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0069 0.0126
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0095 0.0587
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.061 0.3461 0.6521
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Trypanosoma cruzi metacaspase 5, putative 0.0272 0.1524 0.9485
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Echinococcus granulosus cathepsin l1 0.0013 0.0033 0.0051
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0252 0.1407 0.255
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0009 0.001 0.0007
Onchocerca volvulus 0.0252 0.1407 0.244
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0252 0.1407 0.2645
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Loa Loa (eye worm) aldehyde dehydrogenase 0.0009 0.001 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0055 0.0151
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0009 0.001 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0055 0.0284
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0139 0.0253
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0031 0.0129
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0024 0.0033
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0095 0.0095
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0016 0.002
Echinococcus multilocularis cpg binding protein 0.0014 0.0038 0.006
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0016 0.0054 0.0147
Leishmania major glycerol uptake protein, putative 0.0009 0.0013 0.0016
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0006 0.0005
Brugia malayi isocitrate dehydrogenase 0.0011 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0108 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Toxoplasma gondii hypothetical protein 0.0104 0.0556 0.3622
Plasmodium vivax glutathione reductase, putative 0.0068 0.0349 0.2231
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0009 0.001 0.0012
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0964 0.5491 1
Giardia lamblia Protein LRP16 0.0009 0.0012 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0094 0.0529
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0468 0.2646 0.4983
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0013 0.0033 0.0144
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0054 0.0099
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0181 0.0331
Trypanosoma brucei trypanothione reductase 0.0068 0.0349 0.2125
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0069 0.0416
Trypanosoma cruzi glycerol uptake protein, putative 0.0009 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0074 0.0383 0.1158
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0252 0.1407 0.2645
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0104 0.0556 0.1038
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0181 0.0299
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0179 0.0327
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.0429 0.0797
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0009 0.001 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0009 0.0013 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0157 0.086 0.1612
Echinococcus granulosus glycine receptor subunit alpha 1 0.0252 0.1407 0.2645
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0576 0.3265 0.3265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0181 0.0331
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0017 0.0014
Onchocerca volvulus 0.0019 0.0069 0.0104
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0016 0.0041
Onchocerca volvulus 0.0104 0.0556 0.0953
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0069 0.038
Mycobacterium tuberculosis Possible lipoprotein LppD 0.0009 0.0012 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0429 0.0764
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.1893 0.3447
Trypanosoma brucei PAB1-binding protein , putative 0.0045 0.0219 0.1308
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0101
Trypanosoma brucei protein kinase, putative 0.0009 0.0014 0.0023
Plasmodium vivax vivapain-2 0.0019 0.0069 0.038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0017 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0163 0.0897 0.1634
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.0996
Echinococcus multilocularis beta LACTamase domain containing family member 0.0023 0.0094 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Treponema pallidum alginate O-acetylation protein (algI) 0.0009 0.0013 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0009 0.0014 0.005
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0013 0.0035 0.0088
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0252 0.1407 0.2645
Brugia malayi nuclear receptor NHR-67 0.0038 0.0181 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0009 0.001 0.0007
Loa Loa (eye worm) ctsf protein 0.0019 0.0069 0.0126
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0055 0.0284
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0568
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0068 0.0349 0.0348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0101
Giardia lamblia Fructose-bisphosphate aldolase 0.0151 0.0826 0.9727
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0009 0.001 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0042 0.0237
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0378
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Leishmania major importin beta-1 subunit, putative 0.0026 0.0107 0.0609
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.0429 0.0797
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0009 0.0014 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0012 0.0022
Trichomonas vaginalis serine/threonine kinase, putative 0.0009 0.0014 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0009 0.001 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0179 0.1142
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0136 0.074 0.1385
Echinococcus granulosus carbonic anhydrase 0.0163 0.0897 0.1682
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0108
Loa Loa (eye worm) hhat protein 0.0009 0.0013 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0069 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0208 0.0361
Entamoeba histolytica Ran family GTPase 0.0023 0.0094 0.0997
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0012 0.0029 0.0028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.002 0.0076 0.0133
Brugia malayi PHD-finger family protein 0.0015 0.0047 0.0067
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0009 0.0013 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0429 0.0764
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0042 0.0237
Mycobacterium leprae Polyketide synthase Pks13 0.0018 0.0066 0.018
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.001 0.0018 0.0018
Brugia malayi cathepsin L-like precursor 0.0013 0.0033 0.0043
Echinococcus granulosus ubiquitin specific protease 41 0.0013 0.0033 0.0051
Giardia lamblia Kinase, CAMK CAMKL 0.0009 0.0014 0.0043
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0009 0.0013 0.0012
Mycobacterium tuberculosis Probable dehydrogenase 0.0154 0.0847 0.0846
Toxoplasma gondii type I fatty acid synthase, putative 0.0009 0.0011 0.0029
Trypanosoma cruzi glycerol uptake protein, putative 0.0009 0.0013 0.0016
Giardia lamblia Kinase, CAMK CAMKL 0.0009 0.0014 0.0043
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0181 0.0313
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.0897 0.1682
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0009 0.0014 0.0023
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0104 0.0556 0.1038
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0094 0.0546
Schistosoma mansoni hypothetical protein 0.0009 0.001 0.0007
Schistosoma mansoni ran 0.0023 0.0094 0.0165
Echinococcus granulosus serine:threonine protein kinase haspin 0.0009 0.0012 0.001
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.0897 0.1682
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.0429 0.0764
Schistosoma mansoni hypothetical protein 0.0226 0.1256 0.2359
Loa Loa (eye worm) serotonin transporter b 0.0611 0.3468 0.6317
Brugia malayi jmjC domain containing protein 0.0019 0.0069 0.0108
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0056 0.028 0.2493
Brugia malayi RNA binding protein 0.0114 0.0612 0.1099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0252 0.1407 0.2645
Echinococcus granulosus importin subunit beta 1 0.0032 0.0141 0.0256
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0009 0.001 0.0009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0947 0.1724
Onchocerca volvulus Huntingtin homolog 0.0061 0.0312 0.0527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Leishmania major glycerol uptake protein, putative 0.0009 0.0013 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0006 0.0005
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0009 0.0013 0.0031
Brugia malayi Cathepsin L-like precursor 0.0013 0.0033 0.0043
Loa Loa (eye worm) MBOAT family protein 0.0009 0.0013 0.0023
Plasmodium falciparum thioredoxin reductase 0.0023 0.0095 0.0551
Mycobacterium tuberculosis Conserved protein 0.0023 0.0094 0.0094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0095 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Schistosoma mansoni nuclear receptor 0.0038 0.0181 0.0331
Schistosoma mansoni retinoic acid receptor RXR 0.0511 0.2894 0.545
Schistosoma mansoni microtubule-associated protein tau 0.0931 0.5305 1
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0009 0.0014 0.0025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0947 0.1775
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0069 0.0372
Schistosoma mansoni sodium-dependent amino acid transporter 0.0104 0.0556 0.1038
Mycobacterium ulcerans recombinase A 0.0056 0.028 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0033 0.0179
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Echinococcus granulosus o acyltransferase membrane bound domain 0.0009 0.0013 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0095 0.0551
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0154 0.0847 0.0846
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0172
Mycobacterium ulcerans Type I modular polyketide synthase 0.0012 0.0031 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0208 0.0378
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0009 0.0013 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.0429 0.0797
Brugia malayi Pre-SET motif family protein 0.0031 0.0136 0.023
Schistosoma mansoni hypothetical protein 0.0044 0.0214 0.0393
Brugia malayi conserved hypotetical protein 0.0038 0.0181 0.0313
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0042 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0568
Trypanosoma brucei cytochrome P450, putative 0.001 0.0018 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0114 0.0612 0.1145
Echinococcus multilocularis snurportin 1 0.0337 0.1893 0.356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0009 0.0014 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0179 0.1142
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0094 0.0165
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.0897 0.1619
Brugia malayi Cell death protein 3 precursor 0.0498 0.2819 0.5125
Leishmania major metacaspase, putative 0.0272 0.1524 0.9485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Mycobacterium ulcerans thioesterase 0.001 0.0019 0.0041
Trypanosoma cruzi Macro domain containing protein, putative 0.0009 0.0012 0.0011
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0009 0.001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.0372
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0151 0.0826 0.5405
Onchocerca volvulus Alhambra homolog 0.0015 0.0047 0.0064
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.002 0.0076 0.0133
Schistosoma mansoni cpg binding protein 0.0014 0.0038 0.006
Schistosoma mansoni caspase-7 (C14 family) 0.0498 0.2819 0.5309
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Loa Loa (eye worm) ACC-1 protein 0.0252 0.1407 0.2563
Loa Loa (eye worm) hypothetical protein 0.0925 0.527 0.9598
Brugia malayi hypothetical protein 0.0061 0.0312 0.0551
Entamoeba histolytica vacuolar protein sorting 26 0.0009 0.0013 0.0031
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0181 0.033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.0429 0.078
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0116 0.0628 0.1127
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0094 0.0499 0.091
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0012 0.0031 0.0039
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0135 0.0737 0.4794
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0252 0.1407 0.2645
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0055 0.0151
Echinococcus granulosus cyclin dependent kinase 9 0.0009 0.0014 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0055 0.0284
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0013 0.0033 0.0051
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Schistosoma mansoni nAChR subunit 0.0252 0.1407 0.2645
Loa Loa (eye worm) hypothetical protein 0.0084 0.0442 0.0804
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0042 0.0237
Schistosoma mansoni aldehyde dehydrogenase 0.0009 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0101
Loa Loa (eye worm) MBOAT family protein 0.0009 0.0013 0.0023
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0033 0.0043
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0069 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0042 0.0058
Leishmania major cathepsin L-like protease 0.0072 0.0375 0.2288
Brugia malayi latrophilin 2 splice variant baaae 0.0012 0.0027 0.0031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0013 0.0033 0.0144
Onchocerca volvulus 0.0019 0.0069 0.0104
Mycobacterium ulcerans hypothetical protein 0.0017 0.0055 0.0151
Plasmodium falciparum amino acid transporter, putative 0.0104 0.0556 0.3599
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.0429 0.0797
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0009 0.0013 0.0012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0011 0.0024 0.0086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0055 0.0539
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.002 0.0077 0.014
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0009 0.001 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0172 0.0946 0.0945
Leishmania major carbonic anhydrase-like protein 0.0287 0.1606 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0013 0.0043
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Mycobacterium ulcerans hypothetical protein 0.0023 0.0094 0.0271
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0044 0.0213 0.2423
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0069 0.0416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0429 0.0797
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0199 0.1105 1
Echinococcus multilocularis glycine receptor subunit beta 0.0252 0.1407 0.2645
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0055 0.0083
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0047 0.0232
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0009 0.001 0.0007
Echinococcus multilocularis jumonji domain containing protein 0.0021 0.0081 0.0141
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0012 0.0029 0.0028
Entamoeba histolytica acyl-coA synthetase, putative 0.0017 0.0055 0.0539
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0023 0.0094 0.0154
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0108
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0163 0.0897 0.1634
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Echinococcus multilocularis nAChR subunit 0.0136 0.074 0.1385
Entamoeba histolytica hypothetical protein, conserved 0.0009 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.0897 0.1682
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0009 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.0372
Trichomonas vaginalis esterase, putative 0.0023 0.0094 0.0582
Loa Loa (eye worm) hypothetical protein 0.0272 0.1524 0.2775
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Brugia malayi hypothetical protein 0.0044 0.0214 0.0373
Brugia malayi ecdysone receptor 0.0038 0.0181 0.0313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.0429 0.078
Onchocerca volvulus 0.0013 0.0033 0.0041
Loa Loa (eye worm) PHD-finger family protein 0.0015 0.0047 0.0085
Brugia malayi MH2 domain containing protein 0.0094 0.0499 0.0893
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0013 0.0033 0.0051
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0252 0.1407 0.2645
Toxoplasma gondii type I fatty acid synthase, putative 0.0014 0.0039 0.0218
Entamoeba histolytica hypothetical protein 0.0009 0.0013 0.0031
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0009 0.0014 0.0023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.0429 0.0797
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0013 0.0014
Schistosoma mansoni importin beta-1 0.0032 0.0141 0.0256
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0095 0.081
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0208 0.0381
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0009 0.001 0.0009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0154 0.0847 0.0846
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0009 0.001 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0163 0.0897 0.1619
Giardia lamblia DNA repair protein RAD52 0.0155 0.0849 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0104 0.0556 0.1038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0252 0.1407 0.255
Loa Loa (eye worm) hypothetical protein 0.0252 0.1407 0.2563
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0378
Mycobacterium ulcerans aldehyde dehydrogenase 0.0009 0.001 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Brugia malayi Cation transporter family protein 0.0252 0.1407 0.255
Echinococcus granulosus cysteine protease 0.001 0.0016 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0104 0.0556 0.0996
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0094 0.017
Brugia malayi nuclear receptor NHR-88 0.0082 0.0429 0.0764
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.061 0.3461 0.6521
Trypanosoma cruzi Macro domain containing protein, putative 0.0009 0.0012 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0094 0.0167
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0009 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0163 0.0897 0.1634
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0181 0.0331
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0095 0.0273
Leishmania major hypothetical protein, conserved 0.0009 0.0013 0.0016
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0136 0.074 0.1385
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0095 0.0534
Echinococcus multilocularis nAChR subunit 0.0252 0.1407 0.2645
Toxoplasma gondii aldehyde dehydrogenase 0.0157 0.086 0.5626
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0252 0.1407 0.255
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0116 0.0628 0.1174
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0014 0.0014
Onchocerca volvulus 0.0082 0.0429 0.0731
Loa Loa (eye worm) hypothetical protein 0.0611 0.3468 0.6317
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0258
Brugia malayi GSG2 0.0009 0.0012 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0016 0.0078
Treponema pallidum NADH oxidase 0.0023 0.0095 0.0257
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0095 0.0585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0094 0.0167
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0042 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0179 0.1142
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.001 0.0017 0.0035
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0095 0.0585
Onchocerca volvulus 0.0026 0.0111 0.0177
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0179 0.1142
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.0429 0.0764
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0013 0.0033 0.0051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0009 0.0013 0.0031
Loa Loa (eye worm) twinkle helicase 0.0057 0.0287 0.0524
Echinococcus granulosus lysine specific demethylase 5A 0.0019 0.0069 0.0119
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0062 0.0625
Trypanosoma cruzi metacaspase 5, putative 0.0272 0.1524 0.9485
Trypanosoma cruzi metacaspase, putative 0.0272 0.1524 0.9485
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0151 0.0826 0.9727
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0108
Trypanosoma cruzi DNA repair protein, putative 0.0017 0.0059 0.0306
Onchocerca volvulus 0.0023 0.0094 0.0147
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0009 0.0013 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0013 0.0033 0.0042
Echinococcus granulosus sodium and chloride dependent glycine 0.0104 0.0556 0.1038
Plasmodium falciparum phd finger protein, putative 0.0015 0.0047 0.0232
Echinococcus granulosus thioredoxin glutathione reductase 0.0068 0.0349 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1524 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0104 0.0556 0.4885
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0181 0.0313
Brugia malayi nuclear hormone receptor 0.0964 0.5491 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0116 0.0628 0.1174
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0055 0.0151
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0095 0.0168
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0136 0.0855
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0009 0.0013 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0016 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0009 0.001 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.3622
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1524 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0069 0.0707
Loa Loa (eye worm) transcription factor SMAD2 0.0094 0.0499 0.091
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0011 0.0024 0.0086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0055 0.0055
Brugia malayi nuclear receptor RXR 0.0038 0.0181 0.0313
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0252 0.1407 0.255
Trypanosoma cruzi glycerol uptake protein, putative 0.0009 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0104 0.0556 0.1012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.0429 0.0764
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0172
Entamoeba histolytica cysteine proteinase 2 0.001 0.0016 0.0078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Echinococcus multilocularis peregrin 0.0015 0.0047 0.0077
Echinococcus multilocularis L aminoadipate semialdehyde 0.0058 0.0293 0.0541
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0017 0.0058 0.0088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0033 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0416
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0287 0.1606 0.3019
Plasmodium falciparum carbonic anhydrase 0.0163 0.0897 0.5858
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0023 0.009 0.05
Echinococcus multilocularis sodium and chloride dependent glycine 0.0104 0.0556 0.1038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.0429 0.0731
Loa Loa (eye worm) hypothetical protein 0.0136 0.074 0.1348
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0272 0.1524 1
Brugia malayi Appr-1-p processing enzyme family protein 0.0009 0.0012 0.0003
Brugia malayi MBOAT family protein 0.0009 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.0226 0.1256 0.2287
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0094 0.0582
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0016 0.0078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0076
Brugia malayi nuclear hormone receptor 0.0082 0.0429 0.0764
Loa Loa (eye worm) haspin protein kinase 0.0009 0.0012 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0931 0.5305 1
Brugia malayi Cytochrome P450 family protein 0.001 0.0018 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0179 0.1142
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0009 0.0012 0.001
Onchocerca volvulus 0.0009 0.0013 0.0005
Loa Loa (eye worm) ACC-1 protein 0.0252 0.1407 0.2563
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Echinococcus granulosus glycine receptor subunit beta 0.0252 0.1407 0.2645
Trichomonas vaginalis protein kinase atmrk1, putative 0.0009 0.0014 0.005
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0009 0.001 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) hypothetical protein 0.0082 0.0429 0.078
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0016 0.0078
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0009 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.1524 1
Schistosoma mansoni hypothetical protein 0.0182 0.1006 0.1887
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.002 0.0077 0.0134
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0054 0.0276
Echinococcus multilocularis hypothetical protein 0.0009 0.0012 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.0429 0.0764
Onchocerca volvulus 0.0019 0.0069 0.0104
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0272 0.1524 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0104 0.0556 0.1038
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0055 0.0151
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0069 0.0126
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0013 0.0033 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0023 0.0094 0.0172
Loa Loa (eye worm) solute carrier family 6 member 4 0.0611 0.3468 0.6317
Entamoeba histolytica hypothetical protein 0.0044 0.0213 0.2423
Mycobacterium ulcerans polyketide synthase Pks13 0.0018 0.0066 0.0184
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0947 0.1775
Chlamydia trachomatis replicative DNA helicase 0.0199 0.1105 1
Echinococcus granulosus caspase 2 0.0498 0.2819 0.5309
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0094 0.0582
Echinococcus multilocularis muscleblind protein 0.0155 0.0852 0.1596
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0272 0.1524 0.2762
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0252 0.1407 0.2563
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0016 0.0054 0.0314
Trypanosoma cruzi GUP1, putative 0.0009 0.0013 0.0016
Loa Loa (eye worm) MBOAT family protein 0.0009 0.0013 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0014 0.005
Trypanosoma brucei metacaspase MCA2 0.0272 0.1524 0.9485
Plasmodium vivax hypothetical protein, conserved 0.0272 0.1524 1
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0375 0.2288
Brugia malayi hypothetical protein 0.0029 0.0127 0.0214
Onchocerca volvulus 0.0116 0.0628 0.1079
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.0429 0.0797
Toxoplasma gondii PHD-finger domain-containing protein 0.0015 0.0047 0.0267
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0009 0.0014 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0042 0.0237
Schistosoma mansoni aldehyde dehydrogenase 0.0009 0.001 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0375 0.2288
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0252 0.1407 0.2645
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0252 0.1407 0.255
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0024 0.0033
Brugia malayi hypothetical protein 0.0226 0.1256 0.2273
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0095 0.0551
Schistosoma mansoni coup transcription factor 0.0082 0.0429 0.0797
Echinococcus multilocularis carbonic anhydrase 0.0163 0.0897 0.1682
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.3622
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0287 0.1606 0.2912
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0069 0.0126
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0252 0.1407 0.2645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0208 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0416
Mycobacterium ulcerans thioesterase TesA 0.001 0.0019 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0016 0.0041
Brugia malayi hypothetical protein 0.0116 0.0628 0.1127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0027 0.0027
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0094 0.0997
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.0011
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0181 0.0313
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.0429 0.0731
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0107 0.0666
Schistosoma mansoni sodium/chloride dependent transporter 0.0104 0.0556 0.1038
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0009 0.001 0.0007
Plasmodium falciparum MO15-related protein kinase 0.0135 0.0737 0.4794
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0009 0.0014 0.0014
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0009 0.001 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.061 0.3461 0.6521
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0116 0.0628 0.1174
Schistosoma mansoni tar DNA-binding protein 0.0114 0.0612 0.1145
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0042 0.0237
Onchocerca volvulus 0.0038 0.0181 0.0299
Schistosoma mansoni neurotransmitter gated ion channel 0.0116 0.0628 0.1174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0095 0.0534
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0248
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0013 0.0035 0.0035
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0272 0.1524 1
Brugia malayi Muscleblind-like protein 0.0155 0.0852 0.1536
Onchocerca volvulus 0.0019 0.0069 0.0104
Brugia malayi glutathione reductase 0.0068 0.0349 0.0619
Brugia malayi TAR-binding protein 0.0114 0.0612 0.1099
Toxoplasma gondii LsmAD domain-containing protein 0.0045 0.0219 0.14
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.062 0.3521 0.6633
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0058 0.0293 0.0516
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0009 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.1143
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0085
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0179 0.1142
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0054 0.0279
Echinococcus granulosus serine:threonine protein kinase haspin 0.0009 0.0012 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0044 0.0214 0.0393
Loa Loa (eye worm) fibroinase 0.0019 0.0069 0.0126
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0611 0.3468 0.631
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0017 0.0059 0.009
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0042 0.0201
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0179 0.0309
Plasmodium falciparum metacaspase 1 0.0272 0.1524 1
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0024 0.0114
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0069 0.0104
Echinococcus multilocularis carbonic anhydrase 0.0163 0.0897 0.1682
Echinococcus multilocularis cysteine protease 0.0019 0.0069 0.0119
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0179 0.114
Trichomonas vaginalis ap endonuclease, putative 0.0009 0.0014 0.0055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0114 0.0612 0.1115
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0287 0.1606 0.2925
Onchocerca volvulus 0.0017 0.0055 0.0079
Plasmodium vivax unspecified product 0.001 0.0016 0.0031
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0104 0.0556 0.1038
Plasmodium vivax vivapain-3 0.001 0.0016 0.0031
Brugia malayi MBOAT family protein 0.0009 0.0013 0.0005
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.004
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0016 0.0054 0.0147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.0429 0.0797
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0429 0.0764
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0023 0.0094 0.0094
Trypanosoma cruzi cysteine protease, putative 0.001 0.0016 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0095 0.0534
Toxoplasma gondii exonuclease III APE 0.0009 0.0014 0.0053
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.0372
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0252 0.1407 0.255
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0009 0.001 0.0012
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0009 0.001 0.0009
Treponema pallidum gamma-glutamyl phosphate reductase 0.0009 0.001 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0252 0.1407 0.255
Onchocerca volvulus 0.0031 0.0136 0.022
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0141 0.0824
Schistosoma mansoni hypothetical protein 0.0009 0.0012 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0375 0.2288
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0017 0.0055 0.0151
Plasmodium falciparum glutathione reductase 0.0023 0.0095 0.0551
Mycobacterium ulcerans polyketide synthase 0.0013 0.0035 0.009
Mycobacterium ulcerans polyketide synthase Pks9 0.0008 0.0007 0.0003
Mycobacterium leprae Probable polyketide synthase Pks1 0.0013 0.0035 0.0088
Onchocerca volvulus 0.0016 0.0054 0.0077
Echinococcus granulosus MACRO domain containing protein 2 0.0009 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0337 0.1893 0.356
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Loa Loa (eye worm) glutathione reductase 0.0068 0.0349 0.0636
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0104 0.0556 0.1038
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0018 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.0429 0.0797
Loa Loa (eye worm) RNA binding protein 0.0114 0.0612 0.1115
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.0429 0.0764
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0013 0.0035 0.009
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0013 0.0033 0.0051
Trichomonas vaginalis porcupine, putative 0.0009 0.0013 0.0043
Onchocerca volvulus 0.0019 0.0069 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.0429 0.078
Leishmania major glycerol uptake protein, putative 0.0009 0.0013 0.0016
Schistosoma mansoni Replicative DNA helicase 0.0199 0.1105 0.2075
Echinococcus granulosus caspase 8 0.0272 0.1524 0.2864
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0016 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0023 0.0094 0.0094
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0009 0.0012 0.0038
Loa Loa (eye worm) carbonic anhydrase 3 0.0287 0.1606 0.2925
Toxoplasma gondii hypothetical protein 0.0104 0.0556 0.3622
Loa Loa (eye worm) hypothetical protein 0.0498 0.2819 0.5134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0009 0.0013 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0009 0.0014 0.005
Schistosoma mansoni sodium/chloride dependent transporter 0.0611 0.3468 0.6535
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.002 0.0077 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.033
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0116 0.0628 0.1174
Brugia malayi MBOAT family protein 0.0009 0.0013 0.0005
Brugia malayi hypothetical protein 0.0045 0.0219 0.0381
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0094 0.0524
Echinococcus granulosus sodium and chloride dependent glycine 0.0104 0.0556 0.1038
Plasmodium vivax vivapain-2 0.0019 0.0069 0.038
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.0372
Onchocerca volvulus 0.0038 0.0181 0.0299
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0107 0.0666
Toxoplasma gondii thioredoxin reductase 0.0068 0.0349 0.2259
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0095 0.0273
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0095 0.0595
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0104 0.0556 0.1012
Entamoeba histolytica cysteine protease, putative 0.001 0.0016 0.0078
Onchocerca volvulus 0.0023 0.0094 0.0147
Mycobacterium ulcerans esterase/lipase LipP 0.0023 0.0094 0.0271
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0009 0.001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0208 0.0378
Toxoplasma gondii isocitrate dehydrogenase 0.0011 0.0024 0.0114
Entamoeba histolytica protein kinase domain containing protein 0.0009 0.0014 0.0043
Plasmodium vivax importin-beta 2, putative 0.0032 0.0141 0.0858
Loa Loa (eye worm) norepinephrine transporter 0.0611 0.3468 0.6317
Leishmania major serine/threonine kinase-like protein, putative 0.0009 0.0014 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0094 0.0582
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0009 0.0014 0.0014
Mycobacterium ulcerans polyketide synthase 0.0012 0.0031 0.0077
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0009 0.001 0.0012

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 6.6 In vitro inhibition of growth in MCF-7 (estrogen sensitive human breast cancer) cells. ChEMBL. 9836614
Inhibition (functional) > 10 Inhibitory effect on cell growth against MDA-MB231 human breast cancer cells ChEMBL. 9836614
Inhibition (binding) = 14 % Inhibition of Tubulin polymerization by a 40 microM solution of compound ChEMBL. 9836614
Inhibition (binding) = 14 % Inhibition of Tubulin polymerization by a 40 microM solution of compound ChEMBL. 9836614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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