Detailed information for compound 25271

Basic information

Technical information
  • TDR Targets ID: 25271
  • Name: 3-butyl-7-(3,4-dimethoxyphenyl)sulfonyl-1-oct ylpurine-2,6-dione
  • MW: 520.642 | Formula: C25H36N4O6S
  • H donors: 0 H acceptors: 5 LogP: 5.41 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCn1c(=O)n(CCCCCCCC)c(=O)c2c1ncn2S(=O)(=O)c1ccc(c(c1)OC)OC
  • InChi: 1S/C25H36N4O6S/c1-5-7-9-10-11-12-16-28-24(30)22-23(27(25(28)31)15-8-6-2)26-18-29(22)36(32,33)19-13-14-20(34-3)21(17-19)35-4/h13-14,17-18H,5-12,15-16H2,1-4H3
  • InChiKey: AHYHIVMTPQFUJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-butyl-7-(3,4-dimethoxyphenyl)sulfonyl-1-octyl-purine-2,6-dione
  • 3-butyl-7-(3,4-dimethoxyphenyl)sulfonyl-1-octyl-xanthine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) fibroinase 0.0017 0.0074 0.007
Onchocerca volvulus Cell death protein 3 homolog 0.0068 0.06 0.3023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.02 0.195 0.1941
Loa Loa (eye worm) hypothetical protein 0.002 0.0103 0.0099
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Brugia malayi hypothetical protein 0.0106 0.0982 0.0972
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0506 0.8126
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1896
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.0865 0.2112
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0107 0.181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.02 0.195 0.1941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Onchocerca volvulus 0.0048 0.0389 0.1931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0096 0.8838
Entamoeba histolytica hypothetical protein 0.0161 0.155 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0287 0.0683
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0107 0.0103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0261 0.5012
Echinococcus multilocularis GPCR, family 2 0.0035 0.0259 0.0409
Onchocerca volvulus 0.0094 0.0865 0.4394
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0622 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0096 0.0212
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0622 1
Brugia malayi nuclear receptor NHR-88 0.02 0.195 0.1941
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Echinococcus granulosus caspase 2 0.0068 0.06 0.1458
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Loa Loa (eye worm) hypothetical protein 0.0283 0.2802 0.2799
Schistosoma mansoni coup transcription factor 0.02 0.195 0.319
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Schistosoma mansoni hypothetical protein 0.0405 0.4059 0.6642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Onchocerca volvulus 0.0017 0.0074 0.0302
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0107 0.9437
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.02 0.195 0.479
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0259 0.025
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.0865 0.1402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.02 0.195 0.319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Brugia malayi nuclear receptor NHR-67 0.0094 0.0865 0.0856
Brugia malayi Cytochrome P450 family protein 0.0028 0.0185 0.0175
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.02 0.195 0.1941
Leishmania major cytochrome p450-like protein 0.0028 0.0185 0.2029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.02 0.195 0.1941
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0096 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0106 0.0982 0.2399
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.02 0.195 0.3179
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.0109 0.1844
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0427 0.7457
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Schistosoma mansoni hypothetical protein 0.0161 0.155 0.2536
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0109 1
Schistosoma mansoni DNA helicase recq5 0.002 0.0107 0.0175
Plasmodium falciparum metacaspase 1 0.0021 0.0109 1
Trypanosoma brucei protein kinase, putative 0.0059 0.0506 0.8623
Loa Loa (eye worm) hypothetical protein 0.0106 0.0982 0.0978
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0107 0.1856
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0107 0.0158
Echinococcus multilocularis caspase 8 0.0021 0.0109 0.0161
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0074 0.0158
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0506 1
Schistosoma mansoni ap endonuclease 0.0019 0.0096 0.0157
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0021 0.0109 0.0098
Echinococcus multilocularis nuclear receptor nhr 48 0.0094 0.0865 0.1402
Loa Loa (eye worm) hypothetical protein 0.0102 0.0949 0.0946
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0622 0.1018
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0506 0.0812
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Onchocerca volvulus 0.0017 0.0074 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.02 0.195 0.319
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0571 1
Schistosoma mansoni hypothetical protein 0.0079 0.0713 0.1167
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.02 0.195 0.479
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0094 0.0865 0.1402
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0109 0.1746
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0506 0.7873
Loa Loa (eye worm) hypothetical protein 0.0035 0.0259 0.0256
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Echinococcus multilocularis jun protein 0.0098 0.0901 0.146
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0506 1
Schistosoma mansoni nuclear hormone receptor 0.02 0.195 0.319
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0106 0.0982 0.1592
Onchocerca volvulus 0.0017 0.0074 0.0302
Entamoeba histolytica recQ family helicase, putative 0.002 0.0107 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Echinococcus granulosus caspase 8 0.0021 0.0109 0.0243
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0094 0.0865 0.1416
Brugia malayi nuclear hormone receptor 0.02 0.195 0.1941
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0107 0.0225
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0096 0.0086
Brugia malayi MAP kinase sur-1 0.0059 0.0506 0.0496
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0096 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0096 0.0141
Entamoeba histolytica cysteine protease, putative 0.0017 0.0074 0.0479
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0074 0.0479
Echinococcus granulosus ecdysone induced protein 78C 0.02 0.195 0.479
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0513 0.8969
Echinococcus multilocularis thyroid hormone receptor alpha 0.0605 0.6112 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0161 0.155 0.2523
Leishmania major cathepsin L-like protease 0.0066 0.0571 0.9066
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0094 0.0865 0.1402
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0622 0.1512
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Schistosoma mansoni RAR-like nuclear receptor 0.02 0.195 0.319
Brugia malayi Nuclear hormone receptor family member nhr-14 0.02 0.195 0.1941
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0096 0.0092
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0506 0.8846
Echinococcus multilocularis ecdysone induced protein 78C 0.02 0.195 0.3179
Echinococcus multilocularis bloom syndrome protein 0.002 0.0107 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1896
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0074 0.0302
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0107 0.0261
Plasmodium vivax vivapain-2 0.0017 0.0074 0.6832
Brugia malayi ecdysteroid receptor 0.02 0.195 0.1941
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0506 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0107 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0107 0.0238
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0506 0.7873
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0094 0.0865 0.1416
Schistosoma mansoni hypothetical protein 0.0035 0.0259 0.0425
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0185 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0074 0.1237
Schistosoma mansoni caspase-3 (C14 family) 0.0021 0.0109 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Brugia malayi Nuclear hormone receptor-like 1 0.0106 0.0982 0.0972
Brugia malayi bZIP transcription factor family protein 0.0098 0.0901 0.0892
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.0109 0.1844
Loa Loa (eye worm) steroid hormone receptor 0.02 0.195 0.1946
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.001 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0283 0.2802 0.2795
Loa Loa (eye worm) hypothetical protein 0.0068 0.06 0.0597
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Echinococcus multilocularis FTZ F1 alpha 0.02 0.195 0.3179
Brugia malayi steroid hormone receptor 0.02 0.195 0.1941
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0105
Trypanosoma brucei metacaspase MCA2 0.0021 0.0109 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0096 0.0397
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0096 0.1621
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0506 0.8846
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.02 0.195 0.319
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Onchocerca volvulus Bile acid receptor homolog 0.02 0.195 1
Brugia malayi nuclear receptor RXR 0.0106 0.0982 0.0972
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0074 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0506 0.8846
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0389 0.0936
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0185 0.3198
Echinococcus granulosus GPCR family 2 0.0035 0.0259 0.0616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Schistosoma mansoni Tr4/Tr2 (homologue) 0.02 0.195 0.319
Schistosoma mansoni hypothetical protein 0.0387 0.3865 0.6325
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Schistosoma mansoni DNA helicase recq1 0.002 0.0107 0.0175
Echinococcus granulosus geminin 0.0387 0.3865 0.9521
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1323 0.1319
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.001 0.0017
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0109 0.1746
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0571 1
Trypanosoma brucei Metacaspase-4 0.0021 0.0109 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0074 0.0064
Onchocerca volvulus 0.0077 0.0686 0.3464
Schistosoma mansoni caspase-7 (C14 family) 0.0021 0.0109 0.0178
Trypanosoma cruzi metacaspase, putative 0.0021 0.0109 0.1844
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0622 0.1003
Echinococcus granulosus nuclear receptor nhr 48 0.0094 0.0865 0.2112
Loa Loa (eye worm) hypothetical protein 0.0106 0.0982 0.0978
Onchocerca volvulus 0.0017 0.0074 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0874 0.087
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0106 0.0982 0.0978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Echinococcus granulosus caspase 0.0021 0.0109 0.0243
Schistosoma mansoni nuclear receptor 0.0094 0.0865 0.1416
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0074 0.0158
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0323 0.0528
Schistosoma mansoni eyes absent homolog 0.0102 0.0949 0.1553
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0096 0.6331
Entamoeba histolytica hypothetical protein 0.0161 0.155 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0074 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0185 0.0181
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0016 0.0026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.02 0.195 0.3179
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0074 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Brugia malayi tailless protein 0.0094 0.0865 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-49 0.02 0.195 0.1941
Brugia malayi Nuclear hormone receptor-like 1 0.02 0.195 0.1941
Echinococcus granulosus cathepsin l1 0.0017 0.0074 0.0158
Loa Loa (eye worm) cysteine protease 0.0017 0.0074 0.007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.02 0.195 0.1941
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0506 0.0827
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Echinococcus multilocularis geminin 0.0387 0.3865 0.6319
Brugia malayi Cathepsin L-like precursor 0.0012 0.0016 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.02 0.195 0.1941
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.02 0.195 1
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0622 0.1018
Echinococcus granulosus Nuclear hormone receptor HR96 0.0094 0.0865 0.2112
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1896
Onchocerca volvulus 0.0017 0.0074 0.0302
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0622 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1896
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.202 0.3294
Brugia malayi Cell death protein 3 precursor 0.0068 0.06 0.0591
Echinococcus granulosus retinoic acid receptor rxr beta a 0.02 0.195 0.479
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0622 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0405 0.4059 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.02 0.195 0.1946
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0506 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Brugia malayi hypothetical protein 0.0106 0.0982 0.0972
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0161 0.155 0.3803
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1042 0.1033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Trypanosoma cruzi metacaspase, putative 0.0021 0.0109 0.1844
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0074 0.0479
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0004 0.0374
Schistosoma mansoni hypothetical protein 0.0035 0.0259 0.0425
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Loa Loa (eye worm) DR-78 0.0094 0.0865 0.0862
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0506 0.8846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0982 0.0978
Brugia malayi Nuclear hormone receptor family member nhr-31 0.02 0.195 0.1941
Schistosoma mansoni nuclear receptor 0.0094 0.0865 0.1416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.02 0.195 0.1941
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0107 0.9437
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0185 0.1882
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0107 0.1856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.02 0.195 0.1946
Onchocerca volvulus Protein ultraspiracle homolog 0.02 0.195 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.02 0.195 0.1946
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.02 0.195 0.3179
Loa Loa (eye worm) hypothetical protein 0.0094 0.0865 0.0862
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0185 0.3198
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0098 0.0901 0.2201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0094 0.0865 0.4394
Brugia malayi photoreceptor-specific nuclear receptor 0.02 0.195 0.1941
Echinococcus multilocularis caspase 0.0021 0.0109 0.0161
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0107 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0622 1
Echinococcus multilocularis cysteine protease 0.0017 0.0074 0.0105
Brugia malayi nuclear hormone receptor family member nhr-6 0.0094 0.0865 0.0856
Plasmodium falciparum metacaspase-like protein 0.0021 0.0109 1
Brugia malayi hypothetical protein 0.0094 0.0865 0.0856
Brugia malayi hypothetical protein 0.0094 0.0865 0.0856
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1323 0.1319
Echinococcus granulosus cathepsin l1 0.0012 0.0016 0.0014
Brugia malayi Cathepsin L-like precursor 0.0017 0.0074 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.000000000086336
Brugia malayi conserved hypotetical protein 0.0094 0.0865 0.0856
Schistosoma mansoni thyroid hormone receptor 0.0605 0.6112 1
Loa Loa (eye worm) nuclear hormone receptor 0.0094 0.0865 0.0862
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0107 0.1714
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0096 0.1638
Brugia malayi orphan nuclear receptor NR2E1 0.0094 0.0865 0.0856
Brugia malayi nuclear hormone receptor 0.0094 0.0865 0.0856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.02 0.195 0.3179
Schistosoma mansoni hypothetical protein 0.0035 0.0259 0.0425
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0506 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Echinococcus multilocularis cysteine protease 0.0017 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.068 0.067
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0259 0.0256
Schistosoma mansoni jun-related protein 0.0079 0.0713 0.1167
Entamoeba histolytica recQ family DNA helicase 0.001 0.0004 0.0026
Brugia malayi hypothetical protein 0.0102 0.0949 0.094
Brugia malayi nuclear receptor RXR 0.0094 0.0865 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.02 0.195 0.1941
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0287 0.0277
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.0106 0.0982 0.0978
Trypanosoma brucei metacaspase 0.0021 0.0109 0.0266
Brugia malayi nuclear receptor NHR-88 0.0094 0.0865 0.0856
Brugia malayi cathepsin L-like precursor 0.0012 0.0016 0.0006
Brugia malayi Cathepsin L-like precursor 0.0012 0.0016 0.0006
Onchocerca volvulus 0.0094 0.0865 0.4394
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.02 0.195 0.3179
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0074 0.0105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.02 0.195 0.3179
Toxoplasma gondii exonuclease III APE 0.0019 0.0096 0.1543
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0021 0.0109 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Echinococcus granulosus Nuclear hormone receptor HR96 0.0094 0.0865 0.2112
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Brugia malayi Nuclear hormone receptor-like 1 0.0106 0.0982 0.0972
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0098 0.0901 0.146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.02 0.195 0.1946
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0622 1
Trypanosoma cruzi metacaspase, putative 0.0021 0.0109 0.1844
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0016 0.0102
Plasmodium vivax vivapain-2 0.0017 0.0074 0.6832
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0074 0.1193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0506 0.1224
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0107 0.1714
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1896
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0004 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Schistosoma mansoni nuclear receptor nhr-48 0.0094 0.0865 0.1416
Loa Loa (eye worm) hypothetical protein 0.0076 0.068 0.0676
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0106 0.0982 0.1606
Plasmodium vivax metacaspase 1, putative 0.0021 0.0109 1
Brugia malayi hypothetical protein 0.0048 0.0389 0.0379
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0006
Leishmania major metacaspase, putative 0.0021 0.0109 0.0628
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0094 0.0865 0.4394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0096 0.1621
Echinococcus multilocularis caspase 2 0.0068 0.06 0.0967
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0984 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0323 0.0528
Loa Loa (eye worm) hypothetical protein 0.0102 0.0949 0.0946
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0506 0.1224
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0107 0.0238
Schistosoma mansoni hypothetical protein 0.0048 0.0389 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0109 0.1896
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.02 0.195 0.1941
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.02 0.195 0.479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0259 0.025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0074 0.0105
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0405 0.4059 0.6636
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.02 0.195 0.479
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0571 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0107 0.0158
Trypanosoma cruzi metacaspase, putative 0.0021 0.0109 0.1844
Brugia malayi Nuclear hormone receptor E75 0.0094 0.0865 0.0856
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0094 0.0865 0.1402
Echinococcus granulosus nuclear receptor 2DBD gamma 0.02 0.195 0.479
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0506 0.0812
Onchocerca volvulus 0.0017 0.0074 0.0302
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0094 0.0865 0.0862
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0074 0.0121
Loa Loa (eye worm) nuclear receptor NHR-67 0.0094 0.0865 0.0862
Brugia malayi hypothetical protein 0.0077 0.0686 0.0676
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.202 0.4963
Loa Loa (eye worm) hypothetical protein 0.0106 0.0982 0.0978
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0571 1
Schistosoma mansoni nuclear hormone receptor 0.0094 0.0865 0.1416
Onchocerca volvulus 0.0017 0.0074 0.0302
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0185 0.0181
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0016 0.0006
Brugia malayi hypothetical protein 0.0161 0.155 0.1541
Brugia malayi Cathepsin L-like precursor 0.0017 0.0074 0.0064
Brugia malayi Nuclear hormone receptor E75 0.0094 0.0865 0.0856
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0107 0.0097
Loa Loa (eye worm) RecQ helicase 0.002 0.0107 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.02 0.195 0.1941
Brugia malayi Cytochrome P450 family protein 0.0028 0.0185 0.0175
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0096 0.0619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.02 0.195 0.319
Leishmania major cathepsin L-like protease 0.0066 0.0571 0.9066
Echinococcus granulosus jun protein 0.0098 0.0901 0.2201
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.02 0.195 0.319
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0259 0.0409
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0107 0.0593
Loa Loa (eye worm) hypothetical protein 0.0048 0.0389 0.0385
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0107 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.02 0.195 0.1946
Schistosoma mansoni zinc finger protein 0.0094 0.0865 0.1416
Brugia malayi Cathepsin L-like precursor 0.0017 0.0074 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Leishmania major cathepsin L-like protease 0.0066 0.0571 0.9066
Brugia malayi Steroid receptor seven-up type 2 0.02 0.195 0.1941
Toxoplasma gondii cathepsin CPL 0.0017 0.0074 0.1193
Schistosoma mansoni hypothetical protein 0.0387 0.3865 0.6325
Schistosoma mansoni retinoic acid receptor RXR 0.02 0.195 0.319
Schistosoma mansoni hypothetical protein 0.0076 0.068 0.1112
Entamoeba histolytica hypothetical protein 0.0161 0.155 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0261 0.5012
Onchocerca volvulus 0.02 0.195 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0074 0.0105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.02 0.195 0.319
Schistosoma mansoni hypothetical protein 0.0035 0.0259 0.0425
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1042 0.1038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0074 0.0302
Schistosoma mansoni transcription factor LCR-F1 0.0161 0.155 0.2536
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0109 0.1746
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0506 0.8623
Schistosoma mansoni thyroid hormone receptor 0.0605 0.6112 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0074 0.0121
Schistosoma mansoni nuclear hormone receptor 0.0094 0.0865 0.1416
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0096 0.1638
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0021 0.0109 0.0243
Echinococcus granulosus FTZ F1 alpha 0.02 0.195 0.479
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0109 0.1896
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0074 0.1193
Trypanosoma brucei metacaspase 5, putative 0.0021 0.0109 0.0266
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0259 0.0616
Brugia malayi Cathepsin L-like precursor 0.0017 0.0074 0.0064
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0094 0.0865 0.0856
Loa Loa (eye worm) hypothetical protein 0.02 0.195 0.1946
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0074 0.0302
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0094 0.0865 0.2112
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0287 0.0453
Brugia malayi Cathepsin L-like precursor 0.0017 0.0074 0.0064
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0185 0.1699
Brugia malayi ecdysone receptor 0.0094 0.0865 0.0856
Brugia malayi nuclear hormone receptor family member odr-7 0.0094 0.0865 0.0856
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.02 0.195 0.1946
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0021 0.0109 0.0178
Schistosoma mansoni ap endonuclease 0.0019 0.0096 0.0157
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0389 0.0621
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0094 0.0865 0.1402
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.02 0.195 0.479
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0506 0.0502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0074 0.1193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.02 0.195 0.1946
Trypanosoma brucei metacaspase MCA3 0.0021 0.0109 0.0266
Brugia malayi MH2 domain containing protein 0.0139 0.1323 0.1314
Entamoeba histolytica hypothetical protein 0.0161 0.155 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0106 0.0982 0.1606
Echinococcus granulosus bloom syndrome protein 0.002 0.0107 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0074 0.1193
Echinococcus granulosus thyroid hormone receptor alpha 0.0094 0.0865 0.2112
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0287 0.0283
Brugia malayi Cathepsin L-like precursor 0.0017 0.0074 0.0064
Schistosoma mansoni caspase-7 (C14 family) 0.0068 0.06 0.0982

Activities

Activity type Activity value Assay description Source Reference
CTS (functional) = 1.1 Calcitonin (CT) secretion/RIA assay to measure the ability of compound to increase cellular levels and secretion of human CT. ChEMBL. 10737755
Rolipram activity (binding) = 0 % PDE4 30 assay to measure the percent rolipram activity of the PDE4 assay at 30 micro M concentration of the compound. ChEMBL. 10737755
Rolipram activity (binding) = 0 % PDE4 30 assay to measure the percent rolipram activity of the PDE4 assay at 30 micro M concentration of the compound. ChEMBL. 10737755
TAR (functional) = 0.7 CT-luci reporter gene assay to measure the ability to increase transcription of a luciferase receptor gene linked to the human CT gene. ChEMBL. 10737755

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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