TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 475.298 | Formula: C17H18INO5S
H donors: 1 H acceptors: 4 LogP: 3.18 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)N([C@@H](C(=O)O)C)Cc1cccc(c1)I
InChi: 1S/C17H18INO5S/c1-12(17(20)21)19(11-13-4-3-5-14(18)10-13)25(22,23)16-8-6-15(24-2)7-9-16/h3-10,12H,11H2,1-2H3,(H,20,21)/t12-/m1/s1
InChiKey: SMCBDGKQTPLVPB-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tolloid-like 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	bone morphogenetic protein 1b	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	Bone morphogenetic protein 1 homolog precursor, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Loa Loa (eye worm)	AStacin protease	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	IPR000859,CUB,domain-containing	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	ko:K09608 tolloid-like protein 1, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Echinococcus granulosus	Tolloid protein 1	Get druggable targets OG5_130155	All targets in OG5_130155
Echinococcus multilocularis	Tolloid protein 1	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	Iroquois-class homeodomain protein IRX-1, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Schistosoma japonicum	Tolloid-like protein 2 precursor, putative	Get druggable targets OG5_130155	All targets in OG5_130155
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130155	All targets in OG5_130155

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	snurportin 1	0.03	0.7642	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0315	0.8077	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0044	0.058	0.0578
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0154	0.3624	0.5738
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Onchocerca volvulus		0.0044	0.058	0.054
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0044	0.058	0.0578
Schistosoma mansoni	opsin-like receptor	0.0044	0.058	0.0578
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0044	0.058	0.0578
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0076	0.1476	0.1773
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0044	0.058	0.0578
Echinococcus granulosus	glutamate receptor 1	0.0048	0.0688	0.0723
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0154	0.3624	1
Brugia malayi	beta-lactamase family protein	0.0038	0.0411	0.0268
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	amine GPCR	0.0044	0.058	0.0578
Echinococcus granulosus	g protein coupled receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0067	0.1209	0.1417
Schistosoma mansoni	glutamate receptor NMDA	0.0029	0.0159	0.0017
Brugia malayi	RNA, U transporter 1	0.008	0.1575	0.145
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0044	0.058	0.044
Plasmodium falciparum	thioredoxin reductase	0.0069	0.127	0.2389
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0044	0.058	0.044
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.058	0.0578
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	neuropeptide receptor A26	0.0044	0.058	0.0578
Brugia malayi	glutathione reductase	0.0198	0.485	0.4773
Brugia malayi	Dopamine receptor protein 1	0.0044	0.058	0.044
Brugia malayi	Glutamate receptor 1 precursor	0.0067	0.1209	0.1078
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.058	0.0578
Schistosoma mansoni	adenoreceptor	0.0044	0.058	0.0578
Schistosoma mansoni	neuropeptide receptor	0.0044	0.058	0.0578
Brugia malayi	putative neuropeptide receptor	0.0044	0.058	0.044
Brugia malayi	putative neuropeptide receptor NPR1	0.0044	0.058	0.044
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.014	0.3238	0.4124
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0044	0.058	0.0578
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0411	0.0268
Brugia malayi	G protein-coupled receptor	0.0044	0.058	0.044
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0069	0.127	0.1534
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0044	0.058	0.044
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	thioredoxin glutathione reductase	0.0198	0.485	0.6274
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0174	0.4167	0.4081
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.058	0.0578
Schistosoma mansoni	hypothetical protein	0.0044	0.058	0.0578
Echinococcus granulosus	neuropeptide receptor	0.0044	0.058	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	Tolloid protein 1	0.0056	0.0907	0.1014
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.014	0.3238	0.3138
Brugia malayi	G-protein coupled receptor	0.0044	0.058	0.044
Echinococcus granulosus	nmda type glutamate receptor	0.0067	0.1227	0.1441
Schistosoma mansoni	growth hormone secretagogue receptor	0.0044	0.058	0.0578
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0411	0.0509
Schistosoma mansoni	hypothetical protein	0.0044	0.058	0.0578
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0044	0.058	0.0578
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0048	0.0706	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0197	0.4804	0.4727
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	biogenic amine receptor	0.0044	0.058	0.0578
Plasmodium falciparum	glutathione reductase	0.0069	0.127	0.2389
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0069	0.127	0.114
Brugia malayi	Serotonin receptor	0.0044	0.058	0.044
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.058	0.0578
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0069	0.127	0.2673
Echinococcus multilocularis	dro:myosuppressin receptor	0.0044	0.058	0.0578
Brugia malayi	Serotonin receptor	0.0044	0.058	0.044
Brugia malayi	GnHR receptor homolog	0.0044	0.058	0.044
Schistosoma mansoni	hypothetical protein	0.0044	0.058	0.0578
Brugia malayi	AKH receptor	0.0044	0.058	0.044
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.058	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0056	0.0907	0.1014
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.058	0.0578
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	G protein-coupled receptor F59B2.13	0.0044	0.058	0.044
Echinococcus granulosus	G protein coupled receptor 139	0.0044	0.058	0.0578
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0069	0.127	0.2389
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0044	0.058	0.0578
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0044	0.058	0.044
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0411	0.0268
Loa Loa (eye worm)	thioredoxin reductase	0.0198	0.485	0.4773
Brugia malayi	Dopamine receptor	0.0044	0.058	0.044
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.058	0.0578
Brugia malayi	beta-lactamase	0.0038	0.0411	0.0268
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	G protein coupled receptor 139	0.0044	0.058	0.0578
Brugia malayi	follicle stimulating hormone receptor	0.0044	0.058	0.044
Toxoplasma gondii	ABC1 family protein	0.0038	0.0411	0.0562
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Schistosoma mansoni	neuropeptide receptor	0.0044	0.058	0.0578
Schistosoma mansoni	neuropeptide receptor	0.0044	0.058	0.0578
Onchocerca volvulus		0.0044	0.058	0.054
Brugia malayi	Glutamate receptor 2 precursor	0.0067	0.1209	0.1078
Loa Loa (eye worm)	glutathione reductase	0.0198	0.485	0.4773
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0051	0.0766	0.0629
Echinococcus granulosus	serotonin receptor	0.0044	0.058	0.0578
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0159	0.0017
Trichomonas vaginalis	mercuric reductase, putative	0.0069	0.127	0.1572
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0044	0.058	0.0578
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0174	0.4167	0.4081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0268
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0411	0.0353
Brugia malayi	Dopamine receptor protein 2	0.0044	0.058	0.044
Echinococcus granulosus	glutamate receptor 2	0.0076	0.1476	0.1773
Leishmania major	C-8 sterol isomerase-like protein	0.0385	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0044	0.058	0.054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0069	0.127	0.114
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus multilocularis	sex peptide receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	beta-lactamase family protein	0.0038	0.0411	0.0268
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.3238	0.4124
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0069	0.127	0.2389
Echinococcus granulosus	hypothetical protein	0.0044	0.058	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.7642	0.7607
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0069	0.127	0.127
Schistosoma mansoni	biogenic amine receptor	0.0044	0.058	0.0578
Onchocerca volvulus		0.0044	0.058	0.054
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0069	0.127	0.5
Echinococcus multilocularis	glutamate receptor 4	0.0048	0.0688	0.0723
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0069	0.127	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0044	0.058	0.0578
Echinococcus multilocularis	glutamate receptor 2	0.0057	0.0955	0.1079
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0069	0.127	0.1534
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.058	0.0578
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Echinococcus granulosus	orexin receptor type 2	0.0044	0.058	0.0578
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0159	0.0017
Echinococcus granulosus	glutamate receptor 4	0.0048	0.0688	0.0723
Echinococcus multilocularis	glutamate receptor 2	0.0076	0.1476	0.1773
Brugia malayi	neuropeptide F receptor	0.0044	0.058	0.044
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.014	0.3238	0.4124
Onchocerca volvulus		0.0151	0.3542	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0069	0.127	0.1499
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Loa Loa (eye worm)	melatonin receptor type 1A	0.0044	0.058	0.044
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0069	0.127	0.2673
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0069	0.127	0.2673
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.058	0.0578
Echinococcus granulosus	neuropeptide receptor A26	0.0044	0.058	0.0578
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0044	0.058	0.0578
Echinococcus granulosus	7tm_1 domain containing protein	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0268
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.3542	0.3446
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.058	0.044
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.058	0.0578
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0315	0.8077	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	myosin xvIII	0.0044	0.058	0.0578
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0044	0.058	0.0578
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0044	0.058	0.0578
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0044	0.058	0.044
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0159	0.0017
Brugia malayi	neuropeptide F receptor	0.0044	0.058	0.044
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus multilocularis	glutamate receptor 2	0.0067	0.1209	0.1417
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus multilocularis	somatostatin receptor	0.0044	0.058	0.0578
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0411	0.0509
Plasmodium falciparum	glutathione reductase	0.0198	0.485	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0688	0.055
Brugia malayi	Thioredoxin reductase	0.0198	0.485	0.4773
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.058	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Trypanosoma cruzi	trypanothione reductase, putative	0.0069	0.127	0.127
Echinococcus granulosus	neuropeptide s receptor	0.0044	0.058	0.0578
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0069	0.127	0.2389
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Echinococcus granulosus	g-protein coupled receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0688	0.055
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0688	0.055
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0051	0.0766	0.0629
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0044	0.058	0.044
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0044	0.058	0.0578
Trypanosoma brucei	trypanothione reductase	0.0198	0.485	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Trichomonas vaginalis	esterase, putative	0.0038	0.0411	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.058	0.0578
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0044	0.058	0.044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0411	0.0353
Schistosoma mansoni	amine GPCR	0.0044	0.058	0.0578
Brugia malayi	larval opioid receptor	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0385	1	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0069	0.127	0.2389
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.058	0.044
Echinococcus granulosus	g protein coupled receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0411	0.0353
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.058	0.0578
Leishmania major	trypanothione reductase	0.0198	0.485	0.485
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0159	0.0017
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0198	0.485	0.7926
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0044	0.058	0.044
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0069	0.127	0.1534
Onchocerca volvulus		0.0044	0.058	0.054
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.058	0.0578
Leishmania major	hypothetical protein, conserved	0.0038	0.0411	0.0411
Schistosoma mansoni	amine GPCR	0.0044	0.058	0.0578
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.014	0.3238	0.3138
Echinococcus multilocularis	orexin receptor type 2	0.0044	0.058	0.0578
Onchocerca volvulus		0.0044	0.058	0.054
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0315	0.8077	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0069	0.127	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	opsin-like receptor	0.0044	0.058	0.0578
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0069	0.127	0.2673
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0067	0.1227	0.1441
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0069	0.127	0.127
Echinococcus granulosus	dro:myosuppressin receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Plasmodium falciparum	thioredoxin reductase	0.0198	0.485	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0844	0.0708
Loa Loa (eye worm)	glutamate receptor 1	0.0067	0.1209	0.1078
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0044	0.058	0.054
Schistosoma mansoni	hypothetical protein	0.03	0.7642	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0411	0.0411
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0411	0.0509
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0044	0.058	0.044
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus multilocularis	nmda type glutamate receptor	0.0067	0.1227	0.1441
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.058	0.044
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.058	0.0578
Echinococcus multilocularis	serotonin receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	TYRA-2 protein	0.0044	0.058	0.044
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.058	0.0578
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0411	0.0562
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.058	0.0578
Echinococcus granulosus	Tolloid protein 1	0.0056	0.0907	0.1014
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0385	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0044	0.058	0.0578
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0044	0.058	0.0578
Schistosoma mansoni	histamine h1 receptor	0.0044	0.058	0.0578
Echinococcus granulosus	snurportin 1	0.03	0.7642	1
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Schistosoma mansoni	hypothetical protein	0.0044	0.058	0.0578
Brugia malayi	ORL1-like opioid receptor	0.0044	0.058	0.044
Toxoplasma gondii	thioredoxin reductase	0.0198	0.485	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	glutamate receptor 2	0.0057	0.0955	0.1079
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0198	0.485	0.6274
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	G-protein coupled receptor	0.0044	0.058	0.044
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0067	0.1209	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.058	0.044
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0411	0.0268
Toxoplasma gondii	NADPH-glutathione reductase	0.0069	0.127	0.2389
Schistosoma mansoni	neuropeptide receptor	0.0044	0.058	0.0578
Treponema pallidum	NADH oxidase	0.0069	0.127	0.0765
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	amine GPCR	0.0044	0.058	0.0578
Plasmodium vivax	glutathione reductase, putative	0.0198	0.485	1
Echinococcus granulosus	g protein coupled receptor	0.0044	0.058	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Brugia malayi	Melatonin receptor type 1A	0.0044	0.058	0.044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.014	0.3238	0.4124
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus multilocularis	g-protein coupled receptor	0.0044	0.058	0.0578
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Brugia malayi	hypothetical protein	0.0151	0.3542	0.3446
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0056	0.0907	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.058	0.0578
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0411	0.0268
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0159	0.0017
Onchocerca volvulus		0.0044	0.058	0.054
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0076	0.1476	0.1773
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0411	0.0411
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.3238	0.4124
Echinococcus granulosus	7TM GPCR rhodopsin	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0268
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0241	0.6011	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0315	0.8077	1
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	biogenic amine receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.058	0.0578
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.014	0.3238	0.4124
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.058	0.0578
Echinococcus granulosus	neuropeptide receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	allatostatin A receptor	0.0044	0.058	0.0578
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Brugia malayi	sulfakinin receptor protein	0.0044	0.058	0.044
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0315	0.8077	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0069	0.127	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0268
Onchocerca volvulus		0.0044	0.058	0.054
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0069	0.127	0.127
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0411	0.0509
Echinococcus granulosus	sex peptide receptor	0.0044	0.058	0.0578
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0069	0.127	0.127
Echinococcus multilocularis	serotonin receptor	0.0044	0.058	0.0578
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.058	0.0578
Echinococcus granulosus	fmrfamide receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0044	0.058	0.0578
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0069	0.127	0.1499
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0168	0.401	0.392
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0044	0.058	0.044
Trypanosoma cruzi	trypanothione reductase, putative	0.0198	0.485	0.485
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0411	0.0509
Onchocerca volvulus		0.0044	0.058	0.054
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0069	0.127	0.114
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0044	0.058	0.0578
Schistosoma mansoni	opsin-like receptor	0.0044	0.058	0.0578
Mycobacterium tuberculosis	Probable oxidoreductase	0.0069	0.127	0.1534
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0069	0.127	0.5
Loa Loa (eye worm)	AStacin protease	0.0035	0.0331	0.0188
Brugia malayi	RE15519p	0.0044	0.058	0.044
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	neuropeptide s receptor	0.0044	0.058	0.0578
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.058	0.0578
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0069	0.127	0.127
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0154	0.3624	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0044	0.058	0.0578
Trichomonas vaginalis	glutathione reductase, putative	0.0069	0.127	0.1572
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0069	0.127	0.114
Echinococcus granulosus	allatostatin A receptor	0.0044	0.058	0.0578
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0411	0.0353
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0159	0.0017
Brugia malayi	hypothetical protein	0.0044	0.058	0.044
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0069	0.127	0.114
Schistosoma mansoni	neuropeptide f receptor 76f	0.0044	0.058	0.0578
Echinococcus granulosus	somatostatin receptor	0.0044	0.058	0.0578
Onchocerca volvulus		0.0044	0.058	0.054
Loa Loa (eye worm)	hypothetical protein	0.0385	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0268
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0048	0.0706	0.0527
Plasmodium vivax	thioredoxin reductase, putative	0.0198	0.485	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.058	0.0578
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.058	0.0578
Schistosoma mansoni	amine GPCR	0.0044	0.058	0.0578
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.014	0.3238	0.4124
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0268
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.058	0.0578

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 280 nM	Inhibitory activity against procollagen C-proteinase (PCP).	ChEMBL.	11934595
IC50 (binding)	= 280 nM	Inhibitory activity against procollagen C-proteinase (PCP).	ChEMBL.	11934595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 25282