Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium berghei | berghepain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium knowlesi | knowpain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | vivapain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | unspecified product | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | unspecified product | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium yoelii | cysteine proteinase precursor | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | cathepsin B | cysteine proteinase falcipain 1 | 569 aa | 516 aa | 20.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0134 | 0.3516 | 1 |
Plasmodium vivax | vivapain-1 | 0.0134 | 0.3516 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5365 | 1 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5365 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Plasmodium vivax | unspecified product | 0.0134 | 0.3516 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0329 | 0.0934 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5365 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.119 | 0.119 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Plasmodium vivax | unspecified product | 0.0125 | 0.3246 | 0.9231 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0017 | 0.0017 |
Echinococcus granulosus | geminin | 0.0195 | 0.5365 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.119 | 0.119 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.119 | 0.119 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0329 | 0.0329 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0639 | 0.0639 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0001 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0329 | 0.0934 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0329 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0639 | 0.1191 |
Onchocerca volvulus | 0.0348 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0639 | 0.0639 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0329 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0329 | 0.0329 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0329 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0329 | 0.0934 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0329 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.119 | 0.119 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0329 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0001 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 26 % | Growth inhibition of human HCT116 cells at 10 uM after 24 hrs by propidium iodide assay | ChEMBL. | 20064725 |
GI (functional) | = 29 % | Growth inhibition of human H460 cells at 10 uM after 24 hrs by propidium iodide assay | ChEMBL. | 20064725 |
GI (functional) | = 30 % | Growth inhibition of human Calu1 cells at 10 uM after 24 hrs by propidium iodide assay | ChEMBL. | 20064725 |
GI (functional) | = 35 % | Growth inhibition of human ACHN cells at 10 uM after 24 hrs by propidium iodide assay | ChEMBL. | 20064725 |
GI (functional) | = 35 % | Growth inhibition of human PANC1 cells at 10 uM after 24 hrs by propidium iodide assay | ChEMBL. | 20064725 |
IC50 (binding) | = 6.046 | Inhibition of Plasmodium falciparum W2 cysteine protease | ChEMBL. | No reference |
IC50 (binding) | = 0.9 uM | Inhibition of Plasmodium falciparum W2 cysteine protease | ChEMBL. | No reference |
IC50 (functional) | = 3.4 uM | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum clone, CDC/Sierra Leone I (strain D6) | ChEMBL. | 8544179 |
IC50 (functional) | = 3.4 uM | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum clone, CDC/Sierra Leone I (strain D6) | ChEMBL. | 8544179 |
IC50 (functional) | = 3.8 uM | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum clone, CDC/Indochina III (strain W2) | ChEMBL. | 8544179 |
IC50 (functional) | = 3.8 uM | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum clone, CDC/Indochina III (strain W2) | ChEMBL. | 8544179 |
Inhibition (functional) | = 0 % | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha release at 10 uM preincubated for 30 mins before LPS challenge by ELISA | ChEMBL. | 20064725 |
Inhibition (functional) | = 6 % | Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL6 release at 10 uM preincubated for 30 mins before LPS challenge by ELISA | ChEMBL. | 20064725 |
Resistance index (functional) | = 1.1 | Ratio of IC50 of W2 strain to D6 strain. | ChEMBL. | 8544179 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 8544179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.