Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.00654868 | 0.756983 | 0.756983 |
Echinococcus granulosus | acetylcholinesterase | 0.00654868 | 0.756983 | 0.756983 |
Loa Loa (eye worm) | hypothetical protein | 0.00580797 | 0.503492 | 0.503492 |
Trypanosoma brucei | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.00654868 | 0.756983 | 0.756983 |
Plasmodium vivax | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase 4 | 0.00433673 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.00654868 | 0.756983 | 0.756983 |
Loa Loa (eye worm) | hypothetical protein | 0.00580797 | 0.503492 | 0.503492 |
Toxoplasma gondii | peptidase family M13 protein | 0.00725879 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00725879 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00451977 | 0.0626407 | 0.0626407 |
Mycobacterium leprae | probable zinc metalloprotease | 0.00725879 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00597059 | 0.559148 | 0.559148 |
Brugia malayi | Carboxylesterase family protein | 0.00654868 | 0.756983 | 0.756983 |
Echinococcus multilocularis | carboxylesterase 5A | 0.00654868 | 0.756983 | 0.756983 |
Loa Loa (eye worm) | hypothetical protein | 0.00580797 | 0.503492 | 0.503492 |
Loa Loa (eye worm) | hypothetical protein | 0.00654868 | 0.756983 | 0.756983 |
Loa Loa (eye worm) | hypothetical protein | 0.00725879 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.00580797 | 0.503492 | 0.503492 |
Mycobacterium ulcerans | zinc metalloprotease | 0.00725879 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00597059 | 0.559148 | 0.559148 |
Onchocerca volvulus | 0.00451977 | 0.0626407 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.00597059 | 0.559148 | 0.559148 |
Trypanosoma cruzi | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.00654868 | 0.756983 | 0.756983 |
Plasmodium falciparum | histone deacetylase 2 | 0.00433673 | 0 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.00433673 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00725879 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00597059 | 0.559148 | 0.559148 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.00580797 | 0.503492 | 0.503492 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00654868 | 0.756983 | 0.756983 |
Echinococcus multilocularis | acetylcholinesterase | 0.00654868 | 0.756983 | 0.756983 |
Brugia malayi | Peptidase family M13 containing protein | 0.00725879 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00597059 | 0.559148 | 0.559148 |
Leishmania major | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.00725879 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00597059 | 0.559148 | 0.559148 |
Brugia malayi | Carboxylesterase family protein | 0.00654868 | 0.756983 | 0.756983 |
Loa Loa (eye worm) | hypothetical protein | 0.00654868 | 0.756983 | 0.756983 |
Trypanosoma cruzi | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.00725879 | 1 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.00725879 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.00433673 | 0 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.00725879 | 1 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.00433673 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00580797 | 0.503492 | 0.503492 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.00654868 | 0.756983 | 0.756983 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.00725879 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6 nM | In vitro anti-plasmodial activity against Haiti 135 (chloroquine-susceptible) P. falciparum. | ChEMBL. | 9836608 |
IC50 (functional) | = 6 nM | In vitro anti-plasmodial activity against Haiti 135 (chloroquine-susceptible) P. falciparum. | ChEMBL. | 9836608 |
IC50 (functional) | = 58 nM | In vitro anti-plasmodial activity against Indochina I (chloroquine-resistant) P. falciparum. | ChEMBL. | 9836608 |
IC50 (functional) | = 58 nM | In vitro anti-plasmodial activity against Indochina I (chloroquine-resistant) P. falciparum. | ChEMBL. | 9836608 |
IC50 (functional) | = 0.006 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake | ChEMBL. | 18512900 |
IC50 (functional) | = 0.029 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | ChEMBL. | 18512900 |
IC50 (functional) | = 0.058 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake | ChEMBL. | 18512900 |
IC50 (functional) | = 0.066 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay | ChEMBL. | 18512900 |
IC50 (functional) | = 0.357 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | ChEMBL. | 18512900 |
IC50 (functional) | = 0.509 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay | ChEMBL. | 18512900 |
Ratio IC50 (functional) | = 7.17 | Selectivity for chloroquine-resistant Plasmodium falciparum FCB over chloroquine-sensitive Plasmodium falciparum GCO3 as IC50 ratio by SYBR green assay | ChEMBL. | 18512900 |
Ratio IC50 (functional) | = 9.67 | Selectivity for chloroquine-resistant Plasmodium falciparum Indochina I over chloroquine-sensitive Plasmodium falciparum Haiti 135 as IC50 ratio by [3H]hypoxanthine uptake | ChEMBL. | 18512900 |
Ratio IC50 (functional) | = 12.3 | Selectivity for chloroquine-resistant Plasmodium falciparum Dd2 over chloroquine-sensitive Plasmodium falciparum HB3 as IC50 ratio by SYBR green assay | ChEMBL. | 18512900 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18512900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.