TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.566 | Formula: C28H32N2O
H donors: 3 H acceptors: 1 LogP: 6.59 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)CCCCNCCc1c([nH]c2c1cccc2)c1cc(C)ccc1C
InChi: 1S/C28H32N2O/c1-20-10-11-21(2)26(19-20)28-25(24-8-3-4-9-27(24)30-28)16-18-29-17-6-5-7-22-12-14-23(31)15-13-22/h3-4,8-15,19,29-31H,5-7,16-18H2,1-2H3
InChiKey: PQCULIUFXOHFMB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Gonadotropin-releasing hormone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GnHR receptor homolog	Get druggable targets OG5_131719	All targets in OG5_131719

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	allatostatin A receptor	Gonadotropin-releasing hormone receptor	327 aa	279 aa	23.7 %
Echinococcus granulosus	tm gpcr rhodopsin	Gonadotropin-releasing hormone receptor	327 aa	299 aa	23.1 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Gonadotropin-releasing hormone receptor	327 aa	272 aa	23.2 %
Brugia malayi	ORL1-like opioid receptor	Gonadotropin-releasing hormone receptor	327 aa	293 aa	20.8 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Gonadotropin-releasing hormone receptor	327 aa	283 aa	20.1 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	292 aa	19.5 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Gonadotropin-releasing hormone receptor	327 aa	263 aa	23.2 %
Echinococcus multilocularis	neuropeptide receptor	Gonadotropin-releasing hormone receptor	327 aa	263 aa	20.9 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Gonadotropin-releasing hormone receptor	327 aa	288 aa	24.3 %
Echinococcus granulosus	allatostatin A receptor	Gonadotropin-releasing hormone receptor	327 aa	284 aa	22.9 %
Loa Loa (eye worm)	hypothetical protein	Gonadotropin-releasing hormone receptor	327 aa	334 aa	21.6 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	271 aa	20.7 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Gonadotropin-releasing hormone receptor	327 aa	343 aa	21.6 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Gonadotropin-releasing hormone receptor	327 aa	283 aa	19.1 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	336 aa	20.8 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	336 aa	19.0 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Gonadotropin-releasing hormone receptor	327 aa	273 aa	19.8 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Gonadotropin-releasing hormone receptor	327 aa	290 aa	19.7 %
Schistosoma mansoni	neuropeptide receptor	Gonadotropin-releasing hormone receptor	327 aa	263 aa	24.0 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Gonadotropin-releasing hormone receptor	327 aa	305 aa	24.9 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Gonadotropin-releasing hormone receptor	327 aa	288 aa	27.8 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	284 aa	19.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	biogenic amine 5HT receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	neuropeptide FF receptor 2	0.0252	0.0195	0.0851
Brugia malayi	Melatonin receptor type 1A	0.0252	0.0195	0.0195
Echinococcus multilocularis	fmrfamide receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide Y receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0252	0.0195	0.0851
Brugia malayi	G-protein coupled receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	somatostatin receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	TYRA-2 protein	0.0252	0.0195	0.0195
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0056	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	biogenic amine 5HT receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0252	0.0195	0.0195
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	neuropeptide Y receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	dihydrofolate reductase	0.1001	0.091	0.3962
Brugia malayi	AKH receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	7TM GPCR rhodopsin	0.0252	0.0195	0.0851
Echinococcus multilocularis	orexin receptor type 2	0.0252	0.0195	0.0851
Schistosoma mansoni	neuropeptide receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0252	0.0195	0.0851
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	7tm_1 domain containing protein	0.0252	0.0195	0.0851
Schistosoma mansoni	hypothetical protein	0.0252	0.0195	0.0851
Schistosoma mansoni	hypothetical protein	0.0252	0.0195	0.0851
Entamoeba histolytica	alpha-amylase family protein	0.0106	0.0056	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0252	0.0195	0.0195
Brugia malayi	ORL1-like opioid receptor	0.0252	0.0195	0.0195
Schistosoma mansoni	amine GPCR	0.0421	0.0357	0.1552
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.3457	0.3253	1
Brugia malayi	hypothetical protein	0.1168	0.107	0.107
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Mycobacterium ulcerans	thymidylate synthase	0.2456	0.2298	1
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	Serotonin receptor	0.0252	0.0195	0.0195
Brugia malayi	neuropeptide F receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	fmrfamide receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0056	0.0527
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.2456	0.2298	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.001	0.0024
Schistosoma mansoni	biogenic amine receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide Y receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	opsin-like receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	neuropeptides capa receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	hypothetical protein	0.0252	0.0195	0.0851
Echinococcus granulosus	allatostatin A receptor	0.0252	0.0195	0.0851
Trichomonas vaginalis	amylase, putative	0.0106	0.0056	0.0527
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0015	0.004
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.2456	0.2298	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	G protein coupled receptor 139	0.0252	0.0195	0.0851
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.3457	0.3253	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	neuropeptide F-like receptor	0.0252	0.0195	0.0851
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	putative neuropeptide receptor	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	G-protein coupled receptor	0.0252	0.0195	0.0195
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	serotonin receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Echinococcus multilocularis	fmrfamide receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide receptor A26	0.0252	0.0195	0.0851
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0252	0.0195	0.0851
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	adenoreceptor	0.0252	0.0195	0.0851
Giardia lamblia	1,4-alpha-glucan branching enzyme	0.0047	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	melatonin receptor type 1A	0.0252	0.0195	0.0195
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0252	0.0195	0.0195
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0252	0.0195	0.0195
Schistosoma mansoni	myosin xvIII	0.0252	0.0195	0.0851
Brugia malayi	sulfakinin receptor protein	1.053	1	1
Echinococcus granulosus	neuropeptide receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0252	0.0195	0.0851
Brugia malayi	larval opioid receptor	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	hypothetical protein	0.0252	0.0195	0.0851
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0252	0.0195	0.0195
Brugia malayi	Dopamine receptor protein 2	0.0252	0.0195	0.0195
Echinococcus multilocularis	allatostatin A receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0252	0.0195	0.0851
Onchocerca volvulus		0.2456	0.2298	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	dro:myosuppressin receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	dihydrofolate reductase	0.1001	0.091	0.091
Schistosoma mansoni	growth hormone secretagogue receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0252	0.0195	0.0851
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0056	0.0527
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.1001	0.091	0.3962
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	thymidylate synthase	0.2456	0.2298	1
Brugia malayi	Dopamine receptor protein 1	0.0252	0.0195	0.0195
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	tm gpcr rhodopsin	0.0252	0.0195	0.0851
Trichomonas vaginalis	alpha-amylase, putative	0.0106	0.0056	0.0527
Brugia malayi	follicle stimulating hormone receptor	0.0252	0.0195	0.0195
Brugia malayi	Dihydrofolate reductase	0.1001	0.091	0.091
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	g-protein coupled receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	g protein coupled receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	neuropeptide f receptor 76f	0.0252	0.0195	0.0851
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Echinococcus granulosus	g protein coupled receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	somatostatin receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	neuropeptide receptor A26	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	sex peptide receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide receptor	0.0252	0.0195	0.0851
Brugia malayi	GnHR receptor homolog	0.0808	0.0725	0.0725
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0252	0.0195	0.0195
Mycobacterium tuberculosis	Hypothetical protein	0.1168	0.107	0.4655
Schistosoma mansoni	amine GPCR	0.0252	0.0195	0.0851
Echinococcus granulosus	tm gpcr rhodopsin	0.0252	0.0195	0.0851
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0252	0.0195	0.0851
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	dro:myosuppressin receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0252	0.0195	0.0851
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	1.053	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	neuropeptide F receptor	0.0252	0.0195	0.0195
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.1168	0.107	0.3283
Schistosoma mansoni	neuropeptide receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	amine GPCR	0.0252	0.0195	0.0851
Echinococcus multilocularis	dihydrofolate reductase	0.1001	0.091	0.3962
Echinococcus granulosus	neuropeptide receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	amine GPCR	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.1001	0.091	0.3962
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.2456	0.2298	1
Brugia malayi	thymidylate synthase	0.2456	0.2298	0.2298
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0252	0.0195	0.0195
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.3457	0.3253	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	orexin receptor type 2	0.0252	0.0195	0.0851
Echinococcus multilocularis	serotonin receptor	0.0252	0.0195	0.0851
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	Dopamine receptor	0.0252	0.0195	0.0195
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0252	0.0195	0.0851
Echinococcus multilocularis	g-protein coupled receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	hypothetical protein	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	opsin-like receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0015	0.004
Entamoeba histolytica	alpha-amylase family protein	0.0106	0.0056	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Chlamydia trachomatis	dihydrofolate reductase	0.1001	0.091	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	neuropeptide receptor	0.0252	0.0195	0.0851
Brugia malayi	G protein-coupled receptor F59B2.13	0.0252	0.0195	0.0195
Brugia malayi	putative neuropeptide receptor NPR1	0.0252	0.0195	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Brugia malayi	Serotonin receptor	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	neuropeptide F-like receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptides capa receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.3457	0.3253	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	histamine h1 receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0252	0.0195	0.0851
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.3457	0.3253	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0252	0.0195	0.0851
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0252	0.0195	0.0851
Loa Loa (eye worm)	G-protein coupled receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	dihydrofolate reductase	0.1001	0.091	0.3962
Loa Loa (eye worm)	G-protein coupled receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	neuropeptides capa receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	neuropeptide receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	sex peptide receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	neuropeptide Y receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	amine GPCR	0.0252	0.0195	0.0851
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus multilocularis	g protein coupled receptor	0.0252	0.0195	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0252	0.0195	0.0851
Echinococcus multilocularis	serotonin receptor	0.0252	0.0195	0.0851
Brugia malayi	G protein-coupled receptor	0.0252	0.0195	0.0195
Echinococcus granulosus	neuropeptide s receptor	0.0252	0.0195	0.0851
Trichomonas vaginalis	amylase, putative	0.0106	0.0056	0.0527
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0252	0.0195	0.0195
Trichomonas vaginalis	conserved hypothetical protein	0.1168	0.107	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.3457	0.3253	1
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	thymidylate synthase	0.2456	0.2298	1
Brugia malayi	RE15519p	0.0252	0.0195	0.0195
Echinococcus multilocularis	neuropeptides capa receptor	0.0252	0.0195	0.0851
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0252	0.0195	0.0851
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	tm gpcr rhodopsin	0.0252	0.0195	0.0851
Echinococcus multilocularis	neuropeptide s receptor	0.0252	0.0195	0.0851
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0015	0.004
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0252	0.0195	0.0851
Trichomonas vaginalis	alpha-amylase, putative	0.0095	0.0045	0.0423
Brugia malayi	dihydrofolate reductase family protein	0.1001	0.091	0.091
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	g protein coupled receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Loa Loa (eye worm)	neuropeptide F receptor	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Brugia malayi	hypothetical protein	0.0252	0.0195	0.0195
Echinococcus granulosus	g protein coupled receptor	0.0252	0.0195	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0252	0.0195	0.0851
Schistosoma mansoni	opsin-like receptor	0.0252	0.0195	0.0851
Echinococcus granulosus	G protein coupled receptor 139	0.0252	0.0195	0.0851
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0252	0.0195	0.0851
Brugia malayi	neuropeptide F receptor	0.0252	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0195	0.0195
Loa Loa (eye worm)	thymidylate synthase	0.2456	0.2298	0.2298

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.4 uM	Ability to displace [125I]- - radio-labeled buserelin from rat Gonadotropin-releasing hormone receptor	ChEMBL.	11229759
IC50 (binding)	= 0.4 uM	Ability to displace [125I]- - radio-labeled buserelin from rat Gonadotropin-releasing hormone receptor	ChEMBL.	11229759

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 253070