Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase | 0.0141 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0141 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0141 | 1 | 0.5 |
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0141 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0141 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0141 | 1 | 0.5 |
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0141 | 1 | 0.5 |
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0141 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0141 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0141 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0141 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0141 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0141 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0141 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0141 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0141 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0141 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0141 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0141 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0141 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0141 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 uM | Inhibition of [3H]-flunitrazepam binding to GABA-A central Benzodiazepine receptor of bovine brain membranes | ChEMBL. | 2984422 |
IC50 (binding) | = 22 uM | Inhibition of [3H]-flunitrazepam binding to GABA-A central Benzodiazepine receptor of bovine brain membranes | ChEMBL. | 2984422 |
Inhibition (binding) | = 100 % | Inhibition of specific [3H]-flunitrazepam binding to benzodiazepine receptor at 250 uM | ChEMBL. | 2984422 |
Inhibition (binding) | = 100 % | Inhibition of specific [3H]-flunitrazepam binding to benzodiazepine receptor at 250 uM | ChEMBL. | 2984422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.