TDR Targets

Basic information

Technical information

TDR Targets ID: 253197
Name: 2-(5-chloro-1H-indol-3-yl)-N-(4-hydroxyphenyl )-2-oxoacetamide
MW: 314.723 | Formula: C16H11ClN2O3
H donors: 3 H acceptors: 3 LogP: 3.04 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)NC(=O)C(=O)c1c[nH]c2c1cc(Cl)cc2
InChi: 1S/C16H11ClN2O3/c17-9-1-6-14-12(7-9)13(8-18-14)15(21)16(22)19-10-2-4-11(20)5-3-10/h1-8,18,20H,(H,19,22)
InChiKey: HRFUEGPZQUCUSZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(5-chloro-1H-indol-3-yl)-N-(4-hydroxyphenyl)-2-oxo-acetamide
2-(5-chloro-1H-indol-3-yl)-N-(4-hydroxyphenyl)-2-oxo-ethanamide
2-(5-chloro-1H-indol-3-yl)-N-(4-hydroxyphenyl)-2-keto-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	aldehyde reductase, putative	0.0083	0.0919	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.3709	0.5421
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0327	0.0464
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0222	0.0286
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0083	0.0919	0.229
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0286
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0083	0.0919	0.0846
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0287	0.4011	0.6689
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0286
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.0563	0.0487
Entamoeba histolytica	aldose reductase, putative	0.0287	0.4011	1
Echinococcus granulosus	geminin	0.0355	0.5033	0.4993
Schistosoma mansoni	pol-related	0.0287	0.4011	0.3963
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Brugia malayi	RNA, U transporter 1	0.0079	0.0858	0.1361
Onchocerca volvulus		0.0083	0.0919	0.1052
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0287	0.4011	0.5862
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0222	0.0286
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0287	0.4011	0.6689
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0222	0.0144
Trypanosoma cruzi	aldo/keto reductase, putative	0.0287	0.4011	1
Echinococcus multilocularis	microtubule associated protein 2	0.0682	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0053	0.0132
Trichomonas vaginalis	aldo-keto reductase, putative	0.0083	0.0919	0.1343
Toxoplasma gondii	aldo-keto reductase	0.0083	0.0919	0.2187
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0222	0.0325
Echinococcus granulosus	snurportin 1	0.0297	0.4165	0.4118
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.024	0.3291	0.5473
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0287	0.4011	1
Echinococcus granulosus	aldo keto reductase	0.0287	0.4011	0.3963
Schistosoma mansoni	hypothetical protein	0.0355	0.5033	0.4993
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0327	0.025
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0222	0.0325
Onchocerca volvulus		0.0287	0.4011	0.5723
Echinococcus multilocularis	aldo keto reductase	0.0287	0.4011	0.3963
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Trichomonas vaginalis	aldo/keto reductase, putative	0.0287	0.4011	0.5862
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.006	0.0563	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0286
Echinococcus granulosus	hypothetical protein	0.0287	0.4011	0.3963
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Brugia malayi	beta-lactamase family protein	0.0037	0.0222	0.0286
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0287	0.4011	0.5862
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.008	0.0068
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0083	0.0919	0.0846
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0287	0.4011	0.5862
Brugia malayi	beta-lactamase family protein	0.0037	0.0222	0.0286
Echinococcus granulosus	aldo keto reductase	0.0287	0.4011	0.3963
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0083	0.0919	0.1343
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.1499	0.337
Trypanosoma brucei	aldo/keto reductase, putative	0.0083	0.0919	0.2187
Echinococcus multilocularis	geminin	0.0355	0.5033	0.4993
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Leishmania major	hypothetical protein, conserved	0.0037	0.0222	0.0555
Mycobacterium leprae	Possible oxidoreductase	0.0083	0.0919	0.1837
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0327	0.0464
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Trichomonas vaginalis	aldo/keto reductase, putative	0.0287	0.4011	0.5862
Mycobacterium ulcerans	oxidoreductase	0.0287	0.4011	1
Onchocerca volvulus		0.0287	0.4011	0.5723
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Leishmania major	aldo-keto reductase-like protein	0.0287	0.4011	1
Loa Loa (eye worm)	oxidoreductase	0.0287	0.4011	0.6689
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.3709	0.5421
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Trichomonas vaginalis	set domain proteins, putative	0.0474	0.6842	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Plasmodium falciparum	importin beta, putative	0.0028	0.008	0.0309
Schistosoma mansoni	hypothetical protein	0.0355	0.5033	0.4993
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0053	0.0132
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0287	0.4011	0.6689
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Mycobacterium tuberculosis	Conserved protein	0.0083	0.0919	0.1837
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.1499	0.337
Loa Loa (eye worm)	hypothetical protein	0.006	0.0563	0.0862
Trypanosoma cruzi	aldo-keto reductase	0.0287	0.4011	1
Onchocerca volvulus		0.0287	0.4011	0.5723
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0286
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.3709	0.5421
Loa Loa (eye worm)	oxidoreductase	0.0287	0.4011	0.6689
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0083	0.0919	0.2187
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.008	0.0068
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0267	0.3709	0.6179
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Trypanosoma cruzi	aldo/keto reductase, putative	0.0083	0.0919	0.229
Plasmodium falciparum	aldo-keto reductase, putative	0.0083	0.0919	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.3709	0.5421
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0222	0.0144
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.1499	0.1431
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0058	0.053	0.0454
Plasmodium vivax	SET domain protein, putative	0.006	0.0563	0.5892
Toxoplasma gondii	aldose reductase, putative	0.0287	0.4011	1
Echinococcus multilocularis	aldo keto reductase	0.0287	0.4011	0.3963
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.0563	0.0487
Onchocerca volvulus	Glucosylceramidase homolog	0.0175	0.2316	0.3163
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.0563	0.0487
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.2459	0.3594
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.3709	0.5421
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0222	0.0286
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0222	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0919	0.1343
Echinococcus granulosus	voltage gated potassium channel subunit	0.0083	0.0919	0.0846
Echinococcus multilocularis	snurportin 1	0.0297	0.4165	0.4118
Entamoeba histolytica	aldose reductase, putative	0.0287	0.4011	1
Toxoplasma gondii	ABC1 family protein	0.0037	0.0222	0.0428
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0287	0.4011	1
Brugia malayi	follicle stimulating hormone receptor	0.024	0.3291	0.5473
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0083	0.0919	0.229
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0222	0.0555
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Schistosoma mansoni	aldo-keto reductase	0.0287	0.4011	0.3963
Plasmodium vivax	aldehyde reductase, putative	0.0083	0.0919	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0222	0.0144
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0287	0.4011	1
Schistosoma mansoni	aldo-keto reductase	0.0287	0.4011	0.3963
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.008	0.0068
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0222	0.1957
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0083	0.0919	0.1463
Brugia malayi	Pre-SET motif family protein	0.0416	0.597	1
Loa Loa (eye worm)	oxidoreductase	0.0287	0.4011	0.6689
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Trichomonas vaginalis	esterase, putative	0.0037	0.0222	0.0325
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	0.4165	0.6949
Schistosoma mansoni	potassium channel beta	0.0083	0.0919	0.0846
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0327	0.025
Onchocerca volvulus		0.006	0.0563	0.0514
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Brugia malayi	Pre-SET motif family protein	0.006	0.0563	0.0862
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0327	0.025
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0222	0.0555
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.006	0.0563	0.1288
Onchocerca volvulus		0.0474	0.6842	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0122	0.1499	0.1431
Onchocerca volvulus		0.0287	0.4011	0.5723
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.006	0.0563	0.0487
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0327	0.025
Onchocerca volvulus		0.0287	0.4011	0.5723
Trichomonas vaginalis	aldo-keto reductase, putative	0.0083	0.0919	0.1343
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0287	0.4011	0.3963
Echinococcus multilocularis	aldo keto reductase	0.0287	0.4011	0.3963
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0267	0.3709	0.6179
Loa Loa (eye worm)	hypothetical protein	0.0028	0.008	0.0045
Loa Loa (eye worm)	oxidoreductase	0.0287	0.4011	0.6689
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0222	0.0325
Plasmodium vivax	importin-beta 2, putative	0.0028	0.008	0.0309
Echinococcus granulosus	aldehyde reductase	0.0204	0.275	0.2692
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.1499	0.1431
Echinococcus granulosus	aldo keto reductase	0.0287	0.4011	0.3963
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0222	0.0325
Trichomonas vaginalis	aldo-keto reductase, putative	0.0083	0.0919	0.1343
Schistosoma mansoni	hypothetical protein	0.0297	0.4165	0.4118
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0416	0.597	1
Giardia lamblia	Aldose reductase	0.0287	0.4011	0.5
Brugia malayi	NADH-dependent xylose reductase	0.0083	0.0919	0.1463
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0122	0.1499	0.3738
Toxoplasma gondii	aldehyde dehydrogenase	0.0122	0.1499	0.3654
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0122	0.1499	0.1431
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Onchocerca volvulus		0.0287	0.4011	0.5723
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4011	0.6689
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0287	0.4011	0.6689
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0122	0.1499	0.337
Echinococcus multilocularis	aldo keto reductase	0.0287	0.4011	0.3963
Mycobacterium ulcerans	hypothetical protein	0.0083	0.0919	0.1837
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Echinococcus granulosus	histone lysine methyltransferase setb	0.006	0.0563	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0286
Mycobacterium leprae	Conserved hypothetical protein	0.0204	0.275	0.6672
Trypanosoma brucei	prostaglandin f synthase	0.0287	0.4011	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0287	0.4011	1
Leishmania major	prostaglandin f synthase, putative	0.0287	0.4011	1
Brugia malayi	beta-lactamase	0.0037	0.0222	0.0286
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0083	0.0919	0.1463
Brugia malayi	MH2 domain containing protein	0.0115	0.1406	0.2286
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0083	0.0919	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0327	0.025
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0327	0.025
Trichomonas vaginalis	glucosylceramidase, putative	0.0267	0.3709	0.5421
Loa Loa (eye worm)	oxidoreductase	0.0287	0.4011	0.6689
Leishmania major	hypothetical protein, conserved	0.0026	0.0053	0.0132
Mycobacterium tuberculosis	Probable oxidoreductase	0.0287	0.4011	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.006	0.0563	0.0487
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.2459	0.3594
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0083	0.0919	0.2187
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.1406	0.2286
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0222	0.0286
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0238	0.3266	0.8034
Giardia lamblia	Aldose reductase	0.0287	0.4011	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0287	0.4011	0.5862
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.1499	0.337
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0222	0.0325
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Schistosoma mansoni	microtubule-associated protein tau	0.0682	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0222	0.0428
Entamoeba histolytica	aldose reductase, putative	0.0287	0.4011	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0327	0.025
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0287	0.4011	0.3963
Trichomonas vaginalis	aldo/keto reductase, putative	0.0287	0.4011	0.5862
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.1406	0.2286
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0083	0.0919	0.229
Echinococcus multilocularis	aldehyde reductase	0.0204	0.275	0.2692
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.2316	0.3385
Brugia malayi	Importin beta-1 subunit	0.0028	0.008	0.0045

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 23 %	Inhibition of [3H]- flunitrazepam binding to GABA-A central benzodiazepine receptor of bovine cortical membranes at 10 microM	ChEMBL.	8978839
Inhibition (binding)	= 23 %	Inhibition of [3H]- flunitrazepam binding to GABA-A central benzodiazepine receptor of bovine cortical membranes at 10 microM	ChEMBL.	8978839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10495505

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 253197