TDR Targets

Basic information

Technical information

TDR Targets ID: 253317
Name: 3-[[(2S)-2-[bis(2,3-dihydro-1H-inden-1-yloxy) phosphorylmethylamino]-3-(4-phenylphenyl)prop anoyl]amino]propanoic acid
MW: 638.689 | Formula: C37H39N2O6P
H donors: 3 H acceptors: 4 LogP: 3.16 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)CCNC(=O)[C@H](Cc1ccc(cc1)c1ccccc1)NCP(=O)(OC1CCc2c1cccc2)OC1CCc2c1cccc2
InChi: 1S/C37H39N2O6P/c40-36(41)22-23-38-37(42)33(24-26-14-16-28(17-15-26)27-8-2-1-3-9-27)39-25-46(43,44-34-20-18-29-10-4-6-12-31(29)34)45-35-21-19-30-11-5-7-13-32(30)35/h1-17,33-35,39H,18-25H2,(H,38,42)(H,40,41)/t33-,34?,35?,46?/m0/s1
InChiKey: MBDRMJLGUMNUDT-BBJVWRKUSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-[[(2S)-2-[di(indan-1-yloxy)phosphorylmethylamino]-3-(4-phenylphenyl)propanoyl]amino]propanoic acid
3-[[(2S)-2-[bis(1-indanyloxy)phosphorylmethylamino]-1-oxo-3-(4-phenylphenyl)propyl]amino]propanoic acid
3-[[(2S)-2-[di(indan-1-yloxy)phosphorylmethylamino]-3-(4-phenylphenyl)propanoyl]amino]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0004	0.0075	0.0193
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0003	0.0023	0.0023
Onchocerca volvulus		0.0003	0.0023	0.0385
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Brugia malayi	glutaminase DH11.1	0.0133	0.6642	0.901
Loa Loa (eye worm)	dihydrofolate reductase	0.0147	0.7371	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0614	0.0833
Echinococcus multilocularis	dihydrofolate reductase	0.0147	0.7371	0.7371
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0003	0.0023	0.0023
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0003	0.0036	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0004	0.0075	0.0193
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0004	0.0095	0.0095
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Echinococcus granulosus	cpg binding protein	0.0015	0.0626	0.0626
Loa Loa (eye worm)	glutaminase	0.0133	0.6642	0.901
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Schistosoma mansoni	hypothetical protein	0.0004	0.0075	0.0075
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.2821	0.2821
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0003	0.0023	0.0031
Brugia malayi	hypothetical protein	0.0003	0.0023	0.0031
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0056	0.2741	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0003	0.0036	0.002
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0003	0.0052	0.0052
Schistosoma mansoni	protein tyrosine phosphatase	0.0003	0.0023	0.0023
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0003	0.0023	0.0023
Schistosoma mansoni	cpg binding protein	0.0015	0.0626	0.0626
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0003	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Onchocerca volvulus		0.0003	0.0023	0.0385
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0026	0.1222	0.4301
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Onchocerca volvulus		0.0003	0.0023	0.0385
Brugia malayi	CXXC zinc finger family protein	0.0014	0.0586	0.0795
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0003	0.0023	0.0031
Onchocerca volvulus		0.0003	0.0023	0.0385
Echinococcus granulosus	cytochrome P450 2K1	0.0004	0.0075	0.0075
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Onchocerca volvulus		0.0003	0.0023	0.0385
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Leishmania major	cytochrome p450-like protein	0.0004	0.0075	0.0193
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase 1	0.0003	0.0023	0.0031
Echinococcus multilocularis		0.0003	0.0023	0.0023
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0003	0.0023	1
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Brugia malayi	hypothetical protein	0.0003	0.0023	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0058	0.2821	0.2821
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Schistosoma mansoni	cytochrome P450	0.0004	0.0075	0.0075
Schistosoma mansoni	cpg binding protein	0.0015	0.0626	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Mycobacterium leprae	Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf	0.0105	0.5211	0.7039
Onchocerca volvulus		0.0003	0.0023	0.0385
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Mycobacterium ulcerans	glutaminase	0.0133	0.6642	0.9
Onchocerca volvulus		0.0003	0.0023	0.0385
Schistosoma mansoni	hypothetical protein	0.0198	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0004	0.0075	0.0193
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Schistosoma mansoni	glutaminase	0.0133	0.6642	0.6642
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0003	0.0036	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0003	0.0052	0.0052
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.0014	0.0569	0.0677
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0004	0.0075	0.0193
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0003	0.0036	0.002
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0004	0.0075	0.0193
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0003	0.0023	0.0023
Trypanosoma cruzi	cytochrome P450, putative	0.0004	0.0075	0.0193
Brugia malayi	Cytochrome P450 family protein	0.0004	0.0075	0.0102
Onchocerca volvulus		0.0003	0.0023	0.0385
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0147	0.7371	1
Schistosoma mansoni	cpg binding protein	0.0014	0.0586	0.0586
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0003	0.0036	0.002
Toxoplasma gondii	carbamoylphosphate synthetase	0.0014	0.0569	0.1852
Brugia malayi	F/Y-rich N-terminus family protein	0.0004	0.0092	0.0125
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Brugia malayi	cytochrome P450	0.0004	0.0075	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0003	0.0023	0.0023
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0003	0.0023	0.0023
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0003	0.0023	0.0023
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Chlamydia trachomatis	dihydrofolate reductase	0.0147	0.7371	0.5
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0003	0.0023	0.0031
Leishmania major	cytochrome p450-like protein	0.0004	0.0075	0.0193
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Onchocerca volvulus		0.0003	0.0023	0.0385
Onchocerca volvulus		0.0003	0.0023	0.0385
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0058	0.2821	0.3826
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0003	0.0036	0.002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.003	0.1383	0.1383
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0056	0.2741	1
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Echinococcus granulosus	dihydrofolate reductase	0.0147	0.7371	0.7371
Onchocerca volvulus		0.0003	0.0023	0.0385
Brugia malayi	Cytochrome P450 family protein	0.0004	0.0075	0.0102
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0003	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Schistosoma mansoni	protein tyrosine phosphatase	0.0003	0.0023	0.0023
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0003	0.0023	0.0023
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Trichomonas vaginalis	glutaminase, putative	0.0133	0.6642	1
Leishmania major	carbamoyl-phosphate synthase, putative	0.0014	0.0569	0.2009
Brugia malayi	hypothetical protein	0.0003	0.0023	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Schistosoma mansoni	dihydrofolate reductase	0.0147	0.7371	0.7371
Loa Loa (eye worm)	histone methyltransferase	0.0004	0.0095	0.0129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0003	0.0023	0.0023
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0003	0.0023	0.0023
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0058	0.2821	0.2821
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0003	0.0036	0.002
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0058	0.2821	0.2821
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0147	0.7371	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0003	0.0023	0.0023
Loa Loa (eye worm)	cytochrome P450	0.0004	0.0075	0.0102
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0003	0.0023	0.0023
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0056	0.2741	1
Onchocerca volvulus		0.0003	0.0023	0.0385
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Wolbachia endosymbiont of Brugia malayi	AICAR transformylase/IMP cyclohydrolase PurH	0.0105	0.5211	1
Brugia malayi	hypothetical protein	0.0003	0.0023	0.0031
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Onchocerca volvulus		0.0003	0.0023	0.0385
Echinococcus multilocularis	dnaJ subfamily B	0.0198	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0003	0.0023	0.0023
Mycobacterium ulcerans	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	0.0105	0.5211	0.7039
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0003	0.0023	0.0031
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0003	0.0023	0.0023
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0003	0.0052	0.0052
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0003	0.0023	0.0023
Onchocerca volvulus	4.1 G protein, putative homolog	0.0003	0.0023	0.0385
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0056	0.2741	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0003	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0058	0.2821	0.3826
Schistosoma mansoni	protein tyrosine phosphatase	0.0003	0.0023	0.0023
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0003	0.0023	1
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0003	0.0023	0.0023
Onchocerca volvulus		0.0003	0.0023	0.0385
Loa Loa (eye worm)	cytochrome P450 family protein	0.0004	0.0075	0.0102
Trypanosoma brucei	cytochrome P450, putative	0.0004	0.0075	0.0193
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0003	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0004	0.0095	0.0095
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0014	0.0586	0.0795
Onchocerca volvulus		0.0003	0.0023	0.0385
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0003	0.0052	0.0052
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0058	0.2821	0.2821
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Leishmania major	cytochrome p450-like protein	0.0004	0.0075	0.0193
Echinococcus multilocularis		0.0004	0.0075	0.0075
Brugia malayi	dihydrofolate reductase family protein	0.0147	0.7371	1
Schistosoma mansoni	pcd6 interacting protein-related	0.0003	0.0023	0.0023
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0003	0.0023	0.0023
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0003	0.0023	0.0023
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0614	0.0833
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0004	0.0075	0.0193
Mycobacterium tuberculosis	Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo	0.0105	0.5211	0.7039
Brugia malayi	Dihydrofolate reductase	0.0147	0.7371	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Trichomonas vaginalis	helicase, putative	0.0003	0.0036	0.002
Echinococcus multilocularis	hypothetical protein	0.0003	0.0023	0.0023
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0003	0.0052	0.0052
Loa Loa (eye worm)	glutaminase 2	0.0133	0.6642	0.901
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0003	0.0023	0.0023
Giardia lamblia	Protein tyrosine phosphatase	0.0003	0.0023	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	CYP4Cod1	0.0004	0.0075	0.0102
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0003	0.0023	0.0023
Loa Loa (eye worm)	cytochrome P450 family protein	0.0004	0.0075	0.0102
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0003	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0003	0.0023	0.0031
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0003	0.0023	0.0031
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Echinococcus multilocularis	cpg binding protein	0.0015	0.0626	0.0626
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0056	0.2741	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0003	0.0036	0.002
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0036	0.002
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0147	0.7371	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0003	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Schistosoma mansoni	aspartate carbamoyltransferase	0.0014	0.0569	0.0569
Brugia malayi	Cytochrome P450 family protein	0.0004	0.0075	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0023	0.0031
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0003	0.0023	0.0023
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0003	0.0023	1
Onchocerca volvulus		0.0003	0.0023	0.0385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0056	0.2741	1
Onchocerca volvulus		0.0014	0.0586	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ratio (functional)	= 41	Ratio of maximum plasma concentration (C) measured ex vivo to that of IC50 of (10a or 10c) in rat treated intravenously with 10 mg/kg	ChEMBL.	8120868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10484244

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 253317