Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.3545 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.3545 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.071 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0611 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.3545 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.0611 | 0.0561 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.3545 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.3545 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0.0611 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0611 | 0.0679 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0007 | 0.0611 | 0.1434 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0611 | 0.0679 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0007 | 0.0611 | 0.1434 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.4619 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0007 | 0.0611 | 0.1434 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0611 | 0.0679 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0611 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.3545 | 0.4732 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0006 | 0.0442 | 0.0939 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.7357 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.7357 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.7357 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.7357 | 1 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.3545 | 0.4732 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.0611 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4678 | 0.6298 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.2495 | 0.6934 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0611 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0611 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.3545 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.2326 | 0.644 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.3545 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0611 | 0.0679 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0611 | 0.1434 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.2495 | 1 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.3545 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.3545 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.5904 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0007 | 0.0611 | 0.1434 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0611 | 0.0679 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0611 | 0.0508 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4678 | 0.4619 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4678 | 0.6298 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.3545 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.7357 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.7357 | 0.7328 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1132 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.3545 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.071 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.7357 | 0.7328 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.3545 | 0.4732 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.2495 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0611 | 0.0679 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.2326 | 0.644 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.3545 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.2495 | 0.6934 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0611 | 0.1434 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0611 | 0.0679 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0611 | 0.0679 |
Onchocerca volvulus | 0.0028 | 0.4393 | 1 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.5904 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0611 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8867 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 0.8588 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0007 | 0.0611 | 0.0679 |
Schistosoma mansoni | hypothetical protein | 0.0004 | 0.012 | 0.0011 |
Onchocerca volvulus | 0.0023 | 0.3545 | 0.7758 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.2495 | 0.3282 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.0611 | 0.0561 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.3545 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.071 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.2326 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.2495 | 0.3282 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.3545 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.7357 | 0.7328 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.0611 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.2326 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.2495 | 0.3282 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.3545 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.3545 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0611 | 0.0679 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.3545 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0004 | 0.012 | 0.0011 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.3545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.2495 | 0.3282 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1104 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0007 | 0.0611 | 0.1434 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.3545 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0611 | 0.0679 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4393 | 0.4331 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1132 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.0611 | 0.0561 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0007 | 0.0611 | 0.1434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.8588 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0611 | 0.1434 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.3545 | 0.4732 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0611 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.2495 | 0.3282 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.3545 | 0.4732 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0611 | 0.1434 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0007 | 0.0611 | 0.1434 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0007 | 0.0611 | 0.0679 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.8588 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.1132 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.2495 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.7357 | 1 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0007 | 0.0611 | 0.1434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 3.1 ug ml-1 | Antifungal activity against Trichophyton mentagrophytes. | ChEMBL. | 3510297 |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Epidermophyton floccosum. | ChEMBL. | 3510297 |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Microsporum canis | ChEMBL. | 3510297 |
MIC (functional) | > 100 ug ml-1 | Antifungal activity measured against Aspergillus fumigatus | ChEMBL. | 3510297 |
MIC (functional) | > 100 ug ml-1 | Antifungal activity measured against Sporothrix schenck ii. | ChEMBL. | 3510297 |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida parapsilosis. | ChEMBL. | 3510297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.