Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Bos taurus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.4247 | 0.4247 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0005 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.7163 | 0.7163 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7163 | 0.7163 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3848 | 0.3848 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.3848 | 0.3848 |
Brugia malayi | TAR-binding protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0005 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0005 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0005 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4247 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.4247 | 0.4247 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4247 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Brugia malayi | hypothetical protein | 0.0037 | 0.4247 | 0.4247 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4247 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.7163 | 0.7163 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.3848 | 0.3848 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.4247 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0005 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.7163 | 0.7163 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0005 | 0.0005 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.4247 | 0.4247 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0005 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0005 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.4247 | 0.4247 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 nM | Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes. | ChEMBL. | 12408713 |
Ki (binding) | = 12 nM | Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membranes. | ChEMBL. | 12408713 |
Ki (binding) | > 10000 nM | Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes. | ChEMBL. | 12408713 |
Ki (binding) | > 10000 nM | Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX. | ChEMBL. | 12408713 |
Ki (binding) | > 10000 nM | Displacement of [3H]- CGS-21,680 from Adenosine A2a receptor in bovine striatal membranes. | ChEMBL. | 12408713 |
Ki (binding) | > 10000 nM | Displacement of [125I]-AB-MECA from Adenosine A3 receptor in bovine cortical membranes in the presence of 20 nM DPCPX. | ChEMBL. | 12408713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.