Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0366 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0037 | 0.0366 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0037 | 0.0366 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.071 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0509 | 1 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0037 | 0.0366 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0509 | 1 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.071 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0021 | 0.0041 | 0.1131 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0509 | 1 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.0041 | 0.1131 | |
Plasmodium falciparum | LCCL domain-containing protein | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.071 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0021 | 0.0041 | 0.1131 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0021 | 0.0041 | 0.1131 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0509 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0509 | 1 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0037 | 0.0366 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0021 | 0.0041 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0021 | 0.0041 | 0.1131 |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Onchocerca volvulus | 0.0037 | 0.0366 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0041 | 0.1131 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.43 | Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836621 |
Log Ki (binding) | = 6.43 | Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836621 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.