Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.0991 | 0.58 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0382 | 0.1032 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0802 | 0.4325 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0802 | 0.4325 | 0.4325 |
Echinococcus granulosus | thymidylate synthase | 0.0802 | 0.4325 | 1 |
Onchocerca volvulus | 0.0802 | 0.4325 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0778 | 0.4133 | 0.4133 |
Echinococcus multilocularis | integrin alpha 3 | 0.0759 | 0.399 | 0.9224 |
Echinococcus multilocularis | integrin alpha ps | 0.0444 | 0.1521 | 0.3517 |
Brugia malayi | hypothetical protein | 0.0382 | 0.1032 | 0.178 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0802 | 0.4325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.2323 | 0.2323 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0802 | 0.4325 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0802 | 0.4325 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0444 | 0.1521 | 0.3517 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0802 | 0.4325 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0802 | 0.4325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0749 | 0.3911 | 0.3911 |
Echinococcus granulosus | integrin alpha ps | 0.0444 | 0.1521 | 0.3517 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0802 | 0.4325 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0991 | 0.58 | 1 |
Brugia malayi | thymidylate synthase | 0.0802 | 0.4325 | 0.7458 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0802 | 0.4325 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0802 | 0.4325 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0759 | 0.399 | 0.9224 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0749 | 0.3911 | 0.6743 |
Schistosoma mansoni | integrin alpha-ps | 0.0444 | 0.1521 | 0.2623 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0802 | 0.4325 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0802 | 0.4325 | 0.7458 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM l-1 | Inhibitory concentration of the compound against binding of Dopamine receptor D2 by displacement of [3H]-spiperone | ChEMBL. | 10743959 |
IC50 (binding) | > 1000 nM l-1 | Inhibitory concentration of the compound against binding of Dopamine receptor D2 by displacement of [3H]-spiperone | ChEMBL. | 10743959 |
Ki (binding) | = 4.3 nM l-1 | Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor | ChEMBL. | 10743959 |
Ki (binding) | = 4.3 nM l-1 | Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor | ChEMBL. | 10743959 |
Ki (binding) | = 160 nM l-1 | Binding affinity for 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]-ketanserin | ChEMBL. | 10743959 |
Ki (binding) | = 160 nM l-1 | Binding affinity for 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]-ketanserin | ChEMBL. | 10743959 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.