EC (functional)
|
= 5 uM
|
Inhibition of acetylation of histone-4 in human T-24 cancer cells
|
ChEMBL.
|
14613312
|
EC (functional)
|
= 5 uM
|
The relative effective concentration of the compound to induce same level of histone H4 acetylation of human T24 cells by MS-275 at 1 uM
|
ChEMBL.
|
12593661
|
EC (functional)
|
= 5 uM
|
Inhibition of acetylation of histone-4 in human T-24 cancer cells
|
ChEMBL.
|
14613312
|
IC50 (binding)
|
= 3000 nM
|
Inhibition of Histone Deacetylase Enzymatic Assay
|
BINDINGDB.
|
No reference
|
IC50 (functional)
|
= 1 uM
|
Inhibitory concentration of the compound against lung H446 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 1 uM
|
Inhibitory concentration of the compound against lung H446 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 2 uM
|
Inhibitory concentration of the compound against prostate DU145 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 2 uM
|
Inhibitory concentration of the compound against breast MDA-MB231 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 2 uM
|
Inhibitory concentration of the compound against prostate DU145 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 2 uM
|
Inhibitory concentration of the compound against breast MDA-MB231 cell line
|
ChEMBL.
|
12593661
|
IC50 (binding)
|
= 3 uM
|
Inhibitory concentration of the compound against human Histone deacetylase 1
|
ChEMBL.
|
14613312
|
IC50 (binding)
|
= 3 uM
|
Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)
|
ChEMBL.
|
12593661
|
IC50 (binding)
|
= 3 uM
|
Inhibitory concentration of the compound against human Histone deacetylase 1
|
ChEMBL.
|
14613312
|
IC50 (binding)
|
= 3 uM
|
Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 4 uM
|
Inhibitory concentration against HCT116 cells proliferation
|
ChEMBL.
|
14613312
|
IC50 (functional)
|
= 4 uM
|
Inhibitory concentration of the compound against colon HCT116 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 4 uM
|
Inhibitory concentration against HCT116 cells proliferation
|
ChEMBL.
|
14613312
|
IC50 (functional)
|
= 4 uM
|
Inhibitory concentration of the compound against colon HCT116 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 6 uM
|
Inhibitory concentration of the compound against breast MCF-7 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 6 uM
|
Inhibitory concentration of the compound against breast MCF-7 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 8 uM
|
Inhibitory concentration of the compound against T24 cells proliferation
|
ChEMBL.
|
14613312
|
IC50 (functional)
|
= 8 uM
|
Inhibitory concentration of the compound against bladder T24 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 8 uM
|
Inhibitory concentration of the compound against lung A549 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 8 uM
|
Inhibitory concentration of the compound against T24 cells proliferation
|
ChEMBL.
|
14613312
|
IC50 (functional)
|
= 8 uM
|
Inhibitory concentration of the compound against bladder T24 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 8 uM
|
Inhibitory concentration of the compound against lung A549 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 10 uM
|
Inhibitory concentration of the compound against colon SW48 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
= 10 uM
|
Inhibitory concentration of the compound against colon SW48 cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
> 37 uM
|
Inhibitory concentration of the compound against normal fibroblast MRHFcell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
> 37 uM
|
Inhibitory concentration of the compound against normal epithelial HMEC cell line
|
ChEMBL.
|
12593661
|
IC50 (functional)
|
> 37 uM
|
Inhibitory concentration of the compound against normal epithelial HMEC cell line
|
ChEMBL.
|
12593661
|
Inhibition (functional)
|
= 55 %
|
In vivo percent inhibitory activity of intraperitoneally administered compound (40 mg/kg/day) against mice infected with HCT116 tumor
|
ChEMBL.
|
12593661
|
Inhibition (functional)
|
= 55 %
|
In vivo percent inhibitory activity of intraperitoneally administered compound (40 mg/kg/day) against mice infected with HCT116 tumor
|
ChEMBL.
|
12593661
|