Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0355 | 0.9306 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0355 | 0.9306 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0355 | 0.9306 | 0.9306 |
Onchocerca volvulus | Peroxidasin homolog | 0.0355 | 0.9306 | 0.5 |
Brugia malayi | hypothetical protein | 0.0355 | 0.9306 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0355 | 0.9306 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0355 | 0.9306 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0355 | 0.9306 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0355 | 0.9306 | 0.9306 |
Onchocerca volvulus | 0.0355 | 0.9306 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.037 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0355 | 0.9306 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0355 | 0.9306 | 0.9306 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Onchocerca volvulus | 0.0355 | 0.9306 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0355 | 0.9306 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.037 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0355 | 0.9306 | 1 |
Brugia malayi | Peroxidasin | 0.0355 | 0.9306 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0355 | 0.9306 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0355 | 0.9306 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0259 | 0.4942 | 0.4942 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.9306 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0355 | 0.9306 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0355 | 0.9306 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0355 | 0.9306 | 0.9306 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0355 | 0.9306 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0355 | 0.9306 | 0.5 |
Onchocerca volvulus | 0.0355 | 0.9306 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -5.58 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand | ChEMBL. | 9836623 |
Log Ki (binding) | = 5.58 | Binding affinity for rat cortex 5-hydroxytryptamine 1A receptor, by displacement of 0.2 nM [3H]-8-OH-DPAT radioligand | ChEMBL. | 9836623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.