Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0409 | 0.3777 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0861 | 0.9121 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0194 | 0.1226 | 0.1344 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0861 | 0.9121 | 1 |
Onchocerca volvulus | 0.0861 | 0.9121 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0935 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0861 | 0.9121 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0194 | 0.1226 | 0.1344 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0861 | 0.9121 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0194 | 0.1226 | 0.1344 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0194 | 0.1226 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0194 | 0.1226 | 0.1344 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0935 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0409 | 0.3777 | 0.3231 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0194 | 0.1226 | 0.1344 |
Echinococcus granulosus | thymidylate synthase | 0.0861 | 0.9121 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0935 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0935 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0861 | 0.9121 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0861 | 0.9121 | 1 |
Brugia malayi | hypothetical protein | 0.0409 | 0.3777 | 0.4141 |
Echinococcus multilocularis | thymidylate synthase | 0.0861 | 0.9121 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0935 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0194 | 0.1226 | 0.1344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -5.71 | In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assay (SPA) | ChEMBL. | 9836620 |
Log EC50 (functional) | Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against Peroxisome proliferator activated receptor gamma using transfection assay in CV-1 cells; IA = Inactive at 10e-4 M | ChEMBL. | 9836620 | |
Log EC50 (functional) | 0 | Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphatase activity (Transactivation) against Peroxisome proliferator activated receptor gamma using transfection assay in CV-1 cells; IA = Inactive at 10e-4 M | ChEMBL. | 9836620 |
Log Ki (binding) | = 5.71 | In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assay (SPA) | ChEMBL. | 9836620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.