Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | notch protein | 0.0236 | 0.2789 | 0.2789 |
Giardia lamblia | High cysteine protein | 0.0236 | 0.2789 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Putative cubilin | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | notch | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | neural cadherin | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | notch | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Peroxidasin | 0.0823 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | 0.0236 | 0.2789 | 0.2789 | |
Echinococcus granulosus | protein jagged 1 | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Cadherin domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | fibropellin Ia | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0823 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Animal haem peroxidase family protein | 0.0823 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Peroxidase homolog | 0.0823 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0823 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | notch | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | slit 2 protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | peroxidasin | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Animal haem peroxidase family protein | 0.0823 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0823 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0236 | 0.2789 | 0.5 |
Brugia malayi | Muscle positioning protein 4 | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | delta-like protein 1 | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Onchocerca volvulus | 0.0823 | 1 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | protein jagged 2 | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | fibropellin Ia | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | 0.0823 | 1 | 1 | |
Echinococcus granulosus | protein jagged 1 | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0823 | 1 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | 0.0236 | 0.2789 | 0.2789 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0823 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 0.2789 | 0.2789 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Peroxidasin homolog | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | notch | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Peroxidase homolog | 0.0823 | 1 | 1 |
Echinococcus granulosus | neural cadherin | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | Notch2 | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Dual oxidase homolog | 0.0823 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0823 | 1 | 1 |
Onchocerca volvulus | 0.0236 | 0.2789 | 0.2789 | |
Echinococcus multilocularis | notch | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | protein jagged 1 | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | cell polarity protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | 0.0236 | 0.2789 | 0.2789 | |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0823 | 1 | 1 |
Schistosoma mansoni | notch | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | 0.0823 | 1 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | notch | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0823 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0823 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0823 | 1 | 1 |
Schistosoma mansoni | notch | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | septate junction protein | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Slit protein homolog | 0.0236 | 0.2789 | 0.2789 |
Echinococcus granulosus | protein jagged 2 | 0.0236 | 0.2789 | 0.2789 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Schistosoma mansoni | slit | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | Delta serrate ligand family protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0823 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Brugia malayi | EGF-like domain containing protein | 0.0236 | 0.2789 | 0.2789 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0236 | 0.2789 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.2789 | 0.2789 |
Schistosoma mansoni | peroxidasin | 0.0823 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.84 | Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836621 |
Log Ki (binding) | = 6.84 | Inhibition by 50% of in vitro binding to Peroxisome proliferator activated receptor gamma | ChEMBL. | 9836621 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.