Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0131 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0131 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0131 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0131 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0131 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0131 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0131 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0131 | 1 | 1 |
Onchocerca volvulus | 0.0131 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0131 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0131 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0131 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0131 | 1 | 0.5 |
Onchocerca volvulus | 0.0131 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0131 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0131 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0131 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Onchocerca volvulus | 0.0131 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0131 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0131 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Onchocerca volvulus | 0.0131 | 1 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0131 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0131 | 1 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0131 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0131 | 1 | 0.5 |
Onchocerca volvulus | 0.0131 | 1 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0131 | 1 | 0.5 |
Onchocerca volvulus | 0.0131 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0131 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0131 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0131 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0131 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0131 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 50 | Ratio of maximum plasma concentration (C) measured ex vivo to that of IC50 of (10a or 10c) in rat treated intravenously with 10 mg/kg | ChEMBL. | 8120868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.