Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 7 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | Get druggable targets OG5_139351 | All targets in OG5_139351 |
Schistosoma japonicum | ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative | Get druggable targets OG5_139351 | All targets in OG5_139351 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | Get druggable targets OG5_139351 | All targets in OG5_139351 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | Get druggable targets OG5_139351 | All targets in OG5_139351 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | dipeptidyl-peptidase 7 | 492 aa | 471 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 alpha | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.101 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.101 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.101 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Onchocerca volvulus | 0.101 | 0.5 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.101 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.101 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.101 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.101 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.101 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.101 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.101 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.101 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.101 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.101 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.101 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.101 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.49 uM | Inhibitory activity of compound against Dipeptidyl-peptidase II (DPP II) | ChEMBL. | 14584950 |
IC50 (binding) | = 0.49 uM | Inhibitory activity of compound against Dipeptidyl-peptidase II (DPP II) | ChEMBL. | 14584950 |
IC50 (binding) | > 1000 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) | ChEMBL. | 14584950 |
IC50 (binding) | > 1000 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) | ChEMBL. | 14584950 |
Selectivity index (binding) | > 2041 | Selectivity index of compound was determined as value for DPP IV divided by value for DPP II | ChEMBL. | 14584950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.