Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0016 | 0.0264 | 0.5 | |
Onchocerca volvulus | 0.0016 | 0.0264 | 0.5 | |
Loa Loa (eye worm) | TK protein kinase | 0.0116 | 0.8869 | 0.8882 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0112 | 0.8557 | 0.856 |
Brugia malayi | Variant SH3 domain containing protein | 0.0025 | 0.1035 | 0.0796 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.4173 | 0.4035 |
Echinococcus granulosus | tyrosine kinase | 0.0116 | 0.8869 | 0.8838 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.4173 | 0.4035 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.4173 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0128 | 0.9952 | 1 |
Schistosoma mansoni | adapter molecule crk | 0.0025 | 0.1035 | 0.0822 |
Onchocerca volvulus | 0.0016 | 0.0264 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0128 | 0.9952 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0029 | 0.1347 | 0.1118 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0025 | 0.1035 | 0.0796 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0128 | 0.9952 | 0.995 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0116 | 0.8869 | 0.8838 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0025 | 0.1035 | 0.0796 |
Echinococcus granulosus | c src tyrosine kinase | 0.0029 | 0.1347 | 0.1113 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.4173 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.4173 | 0.4052 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0128 | 0.9952 | 0.995 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0025 | 0.1035 | 0.0822 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0025 | 0.1035 | 0.0796 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0016 | 0.0264 | 0.034 |
Onchocerca volvulus | 0.0016 | 0.0264 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.0103 | 0.7758 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0029 | 0.1347 | 0.1118 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.9952 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0128 | 0.9952 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0128 | 0.9952 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0128 | 0.9952 | 1 |
Brugia malayi | SRC-1 | 0.0128 | 0.9952 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.9952 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.4173 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0025 | 0.1035 | 0.0822 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.4173 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0116 | 0.8869 | 0.8838 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0128 | 0.9952 | 0.995 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0103 | 0.7758 | 0.7697 |
Loa Loa (eye worm) | TK protein kinase | 0.0103 | 0.7758 | 0.7735 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.4173 | 0.4015 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.4173 | 0.5 |
Schistosoma mansoni | nck2/grb4 | 0.0025 | 0.1035 | 0.0822 |
Schistosoma mansoni | tyrosine kinase | 0.0029 | 0.1347 | 0.1143 |
Brugia malayi | protein-tyrosine kinase | 0.0116 | 0.8869 | 0.8882 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.4173 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0128 | 0.9952 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0029 | 0.1347 | 0.1113 |
Echinococcus granulosus | NCK adaptor protein | 0.0025 | 0.1035 | 0.0792 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0116 | 0.8869 | 0.8882 |
Onchocerca volvulus | 0.0016 | 0.0264 | 0.5 | |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.4173 | 0.5 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0025 | 0.1035 | 0.0792 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.4173 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0029 | 0.1347 | 0.1143 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0128 | 0.9952 | 1 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0025 | 0.1035 | 0.0796 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.4173 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0029 | 0.1347 | 0.1118 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0112 | 0.8557 | 0.8518 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.4173 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0029 | 0.1347 | 0.1118 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0103 | 0.7758 | 0.7735 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0264 | 0.0028 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.4173 | 0.4035 |
Schistosoma mansoni | tyrosine kinase | 0.0016 | 0.0264 | 0.0028 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0116 | 0.8869 | 0.8882 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0128 | 0.9952 | 0.995 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0128 | 0.9952 | 0.995 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1035 | 0.0796 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0116 | 0.8869 | 0.8882 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0128 | 0.9952 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0128 | 0.9952 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0128 | 0.9952 | 0.995 |
Echinococcus multilocularis | NCK adaptor protein | 0.0025 | 0.1035 | 0.0796 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0025 | 0.1035 | 0.0822 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.4173 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.4173 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0029 | 0.1347 | 0.1143 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0128 | 0.9952 | 0.995 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.4173 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.4173 | 0.4035 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.4173 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.4173 | 0.4015 |
Brugia malayi | Variant SH3 domain containing protein | 0.0025 | 0.1035 | 0.0796 |
Onchocerca volvulus | 0.0016 | 0.0264 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0128 | 0.9952 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (functional) | = 0 % | Evaluation for antihelminthic activity against Hymenolepis nana when the dose was administered orally in mouse. | ChEMBL. | 4032426 |
Clearance (functional) | = 30 % | Antihelmintic activity against Nematospiroides dubius when the dose was administered orally in mouse. | ChEMBL. | 4032426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.