Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0075 | 0.0799 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0259 | 1 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0137 | 0.3881 | 0.335 |
Echinococcus granulosus | hypothetical protein | 0.0259 | 1 | 1 |
Onchocerca volvulus | 0.0259 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0075 | 0.0799 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0259 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0075 | 0.0799 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0259 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0259 | 1 | 0.5 |
Onchocerca volvulus | 0.0259 | 1 | 1 | |
Toxoplasma gondii | PAN domain-containing protein | 0.0137 | 0.3881 | 0.335 |
Echinococcus multilocularis | aldo keto reductase | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0259 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0075 | 0.0799 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0259 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0184 | 0.6248 | 0.5922 |
Echinococcus multilocularis | aldo keto reductase | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Onchocerca volvulus | 0.0259 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0259 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0259 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0259 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0259 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0259 | 1 | 1 |
Onchocerca volvulus | 0.0259 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0259 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0259 | 1 | 1 |
Onchocerca volvulus | 0.0259 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0184 | 0.6248 | 0.5922 |
Schistosoma mansoni | pol-related | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Onchocerca volvulus | 0.0259 | 1 | 1 | |
Onchocerca volvulus | 0.0075 | 0.0799 | 0.0799 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0184 | 0.6248 | 0.5922 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0259 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0259 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0259 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0259 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0259 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0259 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 0.5 uM | compound evaluated for dark induced toxicity toward COLO-26, murine colon carcinoma cell line | ChEMBL. | 12408723 |
LD50 (ADMET) | = 0.5 uM | compound evaluated for dark induced toxicity toward COLO-26, murine colon carcinoma cell line | ChEMBL. | 12408723 |
logD (ADMET) | = 2 | Rate of diffusion of compound between layers and extent addition of H2O/HO- at pH 65.0 phosphate buffer | ChEMBL. | 12408723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.