Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4591 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.4591 | 0.4591 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1767 | 0.1767 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4591 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1767 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3289 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.4591 | 0.4591 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.4591 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4591 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.4591 | 0.4591 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.3289 | 0.3289 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.4591 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (functional) | = 0.372 mM kg-1 | Tested in mouse for significant protection against the lethal effects of 2xLD50 of soman without atropine. | ChEMBL. | 2913310 |
LD50 (functional) | = 0.372 mM kg-1 | Tested in mouse for significant protection against the lethal effects of 2xLD50 of soman without atropine. | ChEMBL. | 2913310 |
logD (ADMET) | < -3 | Partition coefficient (logD7.6) | ChEMBL. | 2913310 |
pKa | = 8.02 | Dissociation constant (pKa) (in 0.1 M phosphate buffer) | ChEMBL. | 2913310 |
Survivors (functional) | = 0 | Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/4 LD50 of 2-PAM. | ChEMBL. | 2913310 |
Survivors (functional) | = 0 | Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/8 LD50 of 2-PAM. | ChEMBL. | 2913310 |
Survivors (functional) | = 0 | Number of surviving mice after the administration of compound and 11.2 mg/kg of atropine sulfate and 1/16 LD50 of 2-PAM. | ChEMBL. | 2913310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.