Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0822 | 0.9688 | 0.9744 |
Brugia malayi | nuclear hormone receptor | 0.0465 | 0.5103 | 0.5185 |
Echinococcus granulosus | histone deacetylase 7 | 0.0834 | 0.9842 | 0.9842 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0834 | 0.9842 | 0.9842 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0822 | 0.9688 | 0.9844 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0822 | 0.9688 | 0.9688 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0834 | 0.9842 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Leishmania major | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0834 | 0.9842 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0225 | 0.2036 | 0.2036 |
Echinococcus granulosus | histone deacetylase 6 | 0.0834 | 0.9842 | 0.9842 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0822 | 0.9688 | 0.9744 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0847 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0822 | 0.9688 | 0.9688 |
Echinococcus granulosus | histone deacetylase 1 | 0.0822 | 0.9688 | 0.9688 |
Brugia malayi | Histone deacetylase 1 | 0.0822 | 0.9688 | 0.9844 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0834 | 0.9842 | 0.9842 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0245 | 0.2288 | 0.2288 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0822 | 0.9688 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0834 | 0.9842 | 0.9842 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0834 | 0.9842 | 0.9842 |
Echinococcus granulosus | histone deacetylase | 0.0834 | 0.9842 | 0.9842 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0366 | 0.3837 | 0.3837 |
Trypanosoma brucei | histone deacetylase 1 | 0.0822 | 0.9688 | 0.9744 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0822 | 0.9688 | 0.9688 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0543 | 0.6103 | 0.3775 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0245 | 0.2288 | 0.2288 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0366 | 0.3837 | 0.3837 |
Echinococcus granulosus | histone deacetylase 6 | 0.0834 | 0.9842 | 0.9842 |
Plasmodium vivax | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0366 | 0.3837 | 0.3837 |
Loa Loa (eye worm) | histone deacetylase | 0.0834 | 0.9842 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0834 | 0.9842 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0822 | 0.9688 | 0.9844 |
Plasmodium falciparum | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0834 | 0.9842 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0484 | 0.5355 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0543 | 0.6103 | 0.6202 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0822 | 0.9688 | 0.9844 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0822 | 0.9688 | 0.9744 |
Brugia malayi | Histone deacetylase family protein | 0.0834 | 0.9842 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0834 | 0.9842 | 0.9842 |
Schistosoma mansoni | histone deacetylase | 0.0822 | 0.9688 | 0.9688 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0543 | 0.6103 | 0.6202 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.3837 | 0.3898 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.5158 | 0.5241 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.4878 | 0.4957 |
Giardia lamblia | Histone deacetylase | 0.0822 | 0.9688 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0366 | 0.3837 | 0.3837 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.142 | 0.1443 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0465 | 0.5103 | 0.5185 |
Brugia malayi | Histone deacetylase family protein | 0.0834 | 0.9842 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0822 | 0.9688 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0834 | 0.9842 | 0.9842 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0822 | 0.9688 | 0.9588 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0834 | 0.9842 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0822 | 0.9688 | 0.9844 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0822 | 0.9688 | 0.9688 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0847 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0822 | 0.9688 | 0.9844 |
Trypanosoma brucei | histone deacetylase 4 | 0.0834 | 0.9842 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0822 | 0.9688 | 0.9744 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0822 | 0.9688 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0822 | 0.9688 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0834 | 0.9842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.5317 | 0.5402 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 109 uM | Antiproliferative activity against human HT29 cells | ChEMBL. | 18023585 |
GI50 (functional) | = 109 uM | Antiproliferative activity against human HT29 cells | ChEMBL. | 18023585 |
IC50 (functional) | = 17 uM | In vitro cytotoxic activity required to inhibit murine lymphocytotic leukemia L1210 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 17 uM | In vitro cytotoxic activity required to inhibit murine lymphocytotic leukemia L1210 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 24 uM | In vitro cytotoxic activity required to inhibit human colon adenocarcinoma HT-29 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 24 uM | In vitro cytotoxic activity required to inhibit human colon adenocarcinoma HT-29 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 26 uM | In vitro cytotoxic activity required to inhibit human chronic myelogenous leukemia K-562 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 26 uM | In vitro cytotoxic activity required to inhibit human chronic myelogenous leukemia K-562 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 27 uM | In vitro cytotoxic activity required to inhibit murine melanoma B16 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 27 uM | In vitro cytotoxic activity required to inhibit murine melanoma B16 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 29 uM | In vitro cytotoxic activity required to inhibit human bladder carcinoma T24 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 29 uM | In vitro cytotoxic activity required to inhibit human bladder carcinoma T24 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 60 uM | In vitro cytotoxic activity required to inhibit human estrogen-sensitive breast adenocarcinoma MCF-7 cell line | ChEMBL. | 14584955 |
IC50 (functional) | = 60 uM | In vitro cytotoxic activity required to inhibit human estrogen-sensitive breast adenocarcinoma MCF-7 cell line | ChEMBL. | 14584955 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 14584955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.