Detailed information for compound 254493

Basic information

Technical information
  • TDR Targets ID: 254493
  • Name: 4-[(E)-2-[4-methoxy-3-(1-methylcyclohexyl)phe nyl]prop-1-enyl]benzoic acid
  • MW: 364.477 | Formula: C24H28O3
  • H donors: 1 H acceptors: 2 LogP: 7.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C1(C)CCCCC1)/C(=C/c1ccc(cc1)C(=O)O)/C
  • InChi: 1S/C24H28O3/c1-17(15-18-7-9-19(10-8-18)23(25)26)20-11-12-22(27-3)21(16-20)24(2)13-5-4-6-14-24/h7-12,15-16H,4-6,13-14H2,1-3H3,(H,25,26)/b17-15+
  • InChiKey: QANMIASYTMOQAE-BMRADRMJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens retinoic acid receptor, alpha Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, gamma Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi nuclear hormone receptor Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) nuclear receptor nhr-7B Get druggable targets OG5_131607 All targets in OG5_131607
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131607 All targets in OG5_131607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.0764 0.075
Schistosoma mansoni tyrosine kinase 0.0486 0.3177 0.3167
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0157 0.0764 0.075
Echinococcus multilocularis orexin receptor type 2 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Lyn 0.0486 0.3177 0.3177
Echinococcus granulosus peptide allatostatin:somatostatin 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0157 0.0764 0.0764
Schistosoma mansoni growth factor receptor-bound protein 0.0093 0.0298 0.0284
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0157 0.0764 0.0689
Brugia malayi Tachykinin-like peptides receptor 99D 0.0157 0.0764 0.0689
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Schistosoma mansoni nck2/grb4 0.0093 0.0298 0.0284
Brugia malayi Serotonin receptor 0.0157 0.0764 0.0689
Schistosoma mansoni opsin-like receptor 0.0157 0.0764 0.075
Brugia malayi Melatonin receptor type 1A 0.0157 0.0764 0.0689
Brugia malayi nuclear hormone receptor 0.0787 0.5385 0.5348
Entamoeba histolytica protein kinase, putative 0.0392 0.2493 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi RE15519p 0.0157 0.0764 0.0689
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0787 0.5385 0.5385
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0157 0.0764 0.0764
Schistosoma mansoni neuropeptide F-like receptor 0.0157 0.0764 0.075
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0486 0.3177 0.3177
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Fyn 0.0486 0.3177 0.3177
Schistosoma mansoni tyrosine kinase 0.0742 0.5062 0.5055
Echinococcus granulosus tyrosine kinase 0.044 0.2839 0.2839
Echinococcus granulosus somatostatin receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Brugia malayi ORL1-like opioid receptor 0.0157 0.0764 0.0689
Echinococcus granulosus sex peptide receptor 0.0157 0.0764 0.0764
Echinococcus granulosus 7TM GPCR rhodopsin 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.012 0.0495 0.0495
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Loa Loa (eye worm) G-protein coupled receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi G protein-coupled receptor F59B2.13 0.0157 0.0764 0.0689
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0465 0.3027 0.3027
Echinococcus granulosus neuropeptide receptor 0.0157 0.0764 0.0764
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Loa Loa (eye worm) hypothetical protein 0.0074 0.0157 0.0157
Schistosoma mansoni histamine h1 receptor 0.0157 0.0764 0.075
Schistosoma mansoni biogenic amine receptor 0.0157 0.0764 0.075
Echinococcus multilocularis tyrosine protein kinase Blk 0.044 0.2839 0.2839
Echinococcus granulosus g protein coupled receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0157 0.0764 0.0764
Echinococcus multilocularis NCK adaptor protein 0.0093 0.0298 0.0298
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.055 0.3651 0.3651
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0157 0.0764 0.0764
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0486 0.3177 0.3177
Echinococcus granulosus tyrosine protein kinase Srms 0.0074 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis neuropeptide receptor 0.0157 0.0764 0.0764
Echinococcus granulosus neuropeptide receptor 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Echinococcus multilocularis somatostatin receptor 0.0157 0.0764 0.0764
Brugia malayi Tyrosine-protein kinase abl-1 0.012 0.0495 0.0417
Echinococcus granulosus epidermal growth factor receptor 0.0769 0.5259 0.5259
Brugia malayi Protein kinase domain containing protein 0.0074 0.0157 0.0077
Loa Loa (eye worm) neuropeptide F receptor 0.0157 0.0764 0.0764
Brugia malayi SH2 domain containing protein 0.0074 0.0157 0.0077
Schistosoma mansoni tyrosine kinase 0.0742 0.5062 0.5055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0157 0.0764 0.113
Brugia malayi G protein-coupled receptor 0.0157 0.0764 0.0689
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0157 0.0764 0.0764
Echinococcus granulosus insulin receptor 0.0465 0.3027 0.3027
Echinococcus granulosus tyrosine protein kinase Src42A 0.0413 0.2643 0.2643
Echinococcus multilocularis G protein coupled receptor 139 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis neuropeptides capa receptor 0.0157 0.0764 0.0764
Echinococcus granulosus biogenic amine 5HT receptor 0.0157 0.0764 0.0764
Brugia malayi AKH receptor 0.0157 0.0764 0.0689
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) SRC-1 0.0486 0.3177 0.3177
Brugia malayi GnHR receptor homolog 0.0157 0.0764 0.0689
Loa Loa (eye worm) TYRA-2 protein 0.0157 0.0764 0.0764
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase HCK 0.0392 0.2493 0.2493
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus 7tm_1 domain containing protein 0.0157 0.0764 0.0764
Echinococcus multilocularis g protein coupled receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0157 0.0764 0.075
Echinococcus multilocularis tyrosine kinase 0.0074 0.0157 0.0157
Schistosoma mansoni tyrosine kinase 0.012 0.0495 0.048
Schistosoma mansoni tyrosine kinase 0.055 0.3651 0.3641
Echinococcus multilocularis growth factor receptor bound protein 2 0.0093 0.0298 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0157 0.0764 0.0764
Schistosoma mansoni myosin xvIII 0.0157 0.0764 0.075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.0764 0.075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Onchocerca volvulus 0.0157 0.0764 0.113
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Echinococcus granulosus dro:myosuppressin receptor 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase shark 0.0074 0.0157 0.0157
Schistosoma mansoni neuropeptide receptor 0.0157 0.0764 0.075
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0486 0.3177 0.3177
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0157 0.0764 0.0764
Echinococcus granulosus neuropeptide s receptor 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.044 0.2839 0.2839
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0093 0.0298 0.0298
Schistosoma mansoni opsin-like receptor 0.0157 0.0764 0.075
Schistosoma mansoni neuropeptide receptor 0.0157 0.0764 0.075
Onchocerca volvulus 0.0157 0.0764 0.113
Schistosoma mansoni tyrosine kinase 0.012 0.0495 0.048
Echinococcus granulosus tachykinin peptides receptor 99D 0.0157 0.0764 0.0764
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Schistosoma mansoni tyrosine kinase 0.1415 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0157 0.0764 0.0764
Brugia malayi putative neuropeptide receptor NPR1 0.0157 0.0764 0.0689
Echinococcus multilocularis neuropeptide FF receptor 2 0.0157 0.0764 0.0764
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0157 0.0764 0.0689
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus multilocularis fmrfamide receptor 0.0157 0.0764 0.0764
Brugia malayi follicle stimulating hormone receptor 0.0157 0.0764 0.0689
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.055 0.3651 0.3651
Echinococcus granulosus hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Echinococcus granulosus neuropeptide FF receptor 2 0.0157 0.0764 0.0764
Echinococcus multilocularis 0.0432 0.2786 0.2786
Schistosoma mansoni biogenic amine receptor 0.0157 0.0764 0.075
Brugia malayi G-protein coupled receptor 0.0157 0.0764 0.0689
Brugia malayi Variant SH3 domain containing protein 0.0093 0.0298 0.0219
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0486 0.3177 0.3177
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0486 0.3177 0.3177
Echinococcus multilocularis dro:myosuppressin receptor 0.0157 0.0764 0.0764
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0157 0.0764 0.075
Echinococcus granulosus neuropeptide Y receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus g protein coupled receptor 0.0157 0.0764 0.0764
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0157 0.0764 0.075
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0074 0.0157 0.0157
Schistosoma mansoni neuropeptide receptor 0.0157 0.0764 0.075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK protein kinase 0.044 0.2839 0.2839
Echinococcus granulosus biogenic amine 5HT receptor 0.0157 0.0764 0.0764
Brugia malayi G-protein coupled receptor 0.0157 0.0764 0.0689
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0157 0.0764 0.075
Brugia malayi neuropeptide F receptor 0.0157 0.0764 0.0689
Echinococcus granulosus tyrosine protein kinase HCK 0.0392 0.2493 0.2493
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0465 0.3027 0.3027
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Protein kinase domain containing protein 0.0074 0.0157 0.0077
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Fyn 0.0486 0.3177 0.3177
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Protein kinase domain containing protein 0.0074 0.0157 0.0077
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Dopamine receptor protein 2 0.0157 0.0764 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0064 0.0081 0.0081
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0093 0.0298 0.0298
Echinococcus multilocularis neuropeptide receptor A26 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Immunoglobulin I-set domain containing protein 0.0566 0.3766 0.3716
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Echinococcus granulosus neuropeptides capa receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis g protein coupled receptor 0.0157 0.0764 0.0764
Echinococcus granulosus serotonin receptor 0.0157 0.0764 0.0764
Schistosoma mansoni tyrosine kinase 0.0074 0.0157 0.0142
Echinococcus granulosus tyrosine protein kinase ABL1 0.0074 0.0157 0.0157
Onchocerca volvulus 0.0157 0.0764 0.113
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus G protein coupled receptor 139 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0486 0.3177 0.3177
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Fyn 0.044 0.2839 0.2839
Echinococcus granulosus allatostatin A receptor 0.0157 0.0764 0.0764
Schistosoma mansoni tyrosine kinase 0.0074 0.0157 0.0142
Schistosoma mansoni biogenic amine (5HT) receptor 0.0157 0.0764 0.075
Echinococcus multilocularis neuropeptide Y receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase shark 0.0074 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0769 0.5259 0.5259
Echinococcus multilocularis insulin receptor 0.0465 0.3027 0.3027
Schistosoma mansoni adapter molecule crk 0.0093 0.0298 0.0284
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Brugia malayi Serotonin receptor 0.0157 0.0764 0.0689
Brugia malayi sulfakinin receptor protein 0.0157 0.0764 0.0689
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0157 0.0764 0.0764
Brugia malayi putative neuropeptide receptor 0.0157 0.0764 0.0689
Loa Loa (eye worm) hypothetical protein 0.0093 0.0298 0.0298
Schistosoma mansoni hypothetical protein 0.0157 0.0764 0.075
Schistosoma mansoni opsin-like receptor 0.0157 0.0764 0.075
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0157 0.0764 0.0689
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Fyn 0.0486 0.3177 0.3177
Echinococcus multilocularis g protein coupled receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Abl 0.012 0.0495 0.0495
Loa Loa (eye worm) melatonin receptor type 1A 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0157 0.0764 0.0764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Echinococcus granulosus NCK adaptor protein 0.0093 0.0298 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0486 0.3177 0.3177
Brugia malayi Protein kinase domain containing protein 0.0465 0.3027 0.2971
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0486 0.3177 0.3177
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0157 0.0764 0.0764
Brugia malayi SRC-1 0.0486 0.3177 0.3121
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0074 0.0157 0.0157
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Onchocerca volvulus 0.0157 0.0764 0.113
Onchocerca volvulus Neuropeptide F receptor homolog 0.0157 0.0764 0.113
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Echinococcus granulosus fibroblast growth factor receptor 4 0.055 0.3651 0.3651
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Schistosoma mansoni alpha-1 adrenergic receptor 0.0157 0.0764 0.075
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) neuropeptide F receptor 0.0157 0.0764 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/INSR protein kinase 0.0465 0.3027 0.3027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0157 0.0764 0.075
Loa Loa (eye worm) TK/ABL protein kinase 0.0074 0.0157 0.0157
Loa Loa (eye worm) TK protein kinase 0.0392 0.2493 0.2493
Onchocerca volvulus 0.0157 0.0764 0.113
Echinococcus granulosus c src tyrosine kinase 0.012 0.0495 0.0495
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0486 0.3177 0.3177
Schistosoma mansoni tyrosine kinase 0.0769 0.5259 0.5251
Onchocerca volvulus 0.0157 0.0764 0.113
Schistosoma mansoni amine GPCR 0.0157 0.0764 0.075
Echinococcus multilocularis serotonin receptor 0.0157 0.0764 0.0764
Echinococcus granulosus neuropeptide Y receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0157 0.0764 0.0764
Schistosoma mansoni tyrosine kinase 0.0486 0.3177 0.3167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0157 0.0764 0.0764
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0157 0.0764 0.075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.0764 0.0764
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis allatostatin A receptor 0.0157 0.0764 0.0764
Brugia malayi Protein kinase domain containing protein 0.0074 0.0157 0.0077
Echinococcus multilocularis epidermal growth factor receptor 0.1415 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0157 0.0764 0.0689
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0157 0.0764 0.0764
Schistosoma mansoni growth factor receptor-bound protein 0.0093 0.0298 0.0284
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0149 0.0134
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Echinococcus granulosus tyrosine kinase 0.0074 0.0157 0.0157
Schistosoma mansoni neuropeptide f receptor 76f 0.0157 0.0764 0.075
Onchocerca volvulus 0.0157 0.0764 0.113
Echinococcus granulosus neuropeptides capa receptor 0.0157 0.0764 0.0764
Echinococcus granulosus orexin receptor type 2 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0074 0.0157 0.0157
Echinococcus granulosus g-protein coupled receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Srms 0.044 0.2839 0.2839
Echinococcus granulosus tyrosine protein kinase Src64B 0.0486 0.3177 0.3177
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus multilocularis sex peptide receptor 0.0157 0.0764 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0486 0.3177 0.3177
Schistosoma mansoni tyrosine kinase 0.0465 0.3027 0.3017
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0157 0.0764 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Variant SH3 domain containing protein 0.0093 0.0298 0.0219
Echinococcus granulosus tyrosine protein kinase Blk 0.044 0.2839 0.2839
Echinococcus granulosus fmrfamide receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis neuropeptides capa receptor 0.0157 0.0764 0.0764
Echinococcus granulosus growth factor receptor bound protein 2 0.0093 0.0298 0.0298
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0413 0.2643 0.2643
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Schistosoma mansoni tyrosine kinase 0.0742 0.5062 0.5055
Schistosoma mansoni tyrosine kinase 0.0769 0.5259 0.5251
Brugia malayi Dopamine receptor protein 1 0.0157 0.0764 0.0689
Brugia malayi Sex muscle abnormal protein 5 0.0093 0.0298 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/EGFR protein kinase 0.1415 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Schistosoma mansoni hypothetical protein 0.0157 0.0764 0.075
Echinococcus multilocularis g-protein coupled receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Echinococcus multilocularis fmrfamide receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Schistosoma mansoni neuropeptide F-like receptor 0.0157 0.0764 0.075
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0157 0.0764 0.075
Onchocerca volvulus 0.0157 0.0764 0.113
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0157 0.0764 0.075
Brugia malayi larval opioid receptor 0.0157 0.0764 0.0689
Echinococcus multilocularis fibroblast growth factor receptor 4 0.055 0.3651 0.3651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0157 0.0764 0.0764
Echinococcus granulosus epidermal growth factor receptor 0.1415 1 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi Protein kinase domain containing protein 0.0074 0.0157 0.0077
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0486 0.3177 0.3177
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0157 0.0764 0.075
Echinococcus multilocularis epidermal growth factor receptor 0.0769 0.5259 0.5259
Brugia malayi SH2 domain containing protein 0.0074 0.0157 0.0077
Schistosoma mansoni biogenic amine receptor 0.0157 0.0764 0.075
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0157 0.0764 0.075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Onchocerca volvulus 0.0157 0.0764 0.113
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0093 0.0298 0.0284
Loa Loa (eye worm) TK protein kinase 0.0566 0.3766 0.3766
Schistosoma mansoni growth hormone secretagogue receptor 0.0157 0.0764 0.075
Echinococcus multilocularis neuropeptide Y receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0157 0.0764 0.075
Schistosoma mansoni amine GPCR 0.0157 0.0764 0.075
Schistosoma mansoni amine GPCR 0.0157 0.0764 0.075
Schistosoma mansoni hypothetical protein 0.0157 0.0764 0.075
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0769 0.5259 0.5259
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0157 0.0764 0.0764
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.0764 0.0764
Loa Loa (eye worm) G-protein coupled receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi hypothetical protein 0.0074 0.0157 0.0077
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Brugia malayi hypothetical protein 0.0157 0.0764 0.0689
Echinococcus granulosus tyrosine protein kinase Btk29A 0.012 0.0495 0.0495
Schistosoma mansoni adenoreceptor 0.0157 0.0764 0.075
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.0764 0.0764
Onchocerca volvulus 0.0157 0.0764 0.113
Brugia malayi protein-tyrosine kinase 0.044 0.2839 0.2781
Echinococcus multilocularis neuropeptide receptor 0.0157 0.0764 0.0764
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0157 0.0764 0.0689
Schistosoma mansoni amine GPCR 0.0157 0.0764 0.075
Echinococcus granulosus g protein coupled receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Src42A 0.0486 0.3177 0.3177
Echinococcus multilocularis serotonin receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) TK/FER protein kinase 0.0074 0.0157 0.0157
Brugia malayi neuropeptide F receptor 0.0157 0.0764 0.0689
Brugia malayi Dopamine receptor 0.0157 0.0764 0.0689
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0157 0.0764 0.0764
Echinococcus multilocularis G-protein coupled receptor, putative 0.0157 0.0764 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.0157 0.0764 0.0764
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.0764 0.0764
Schistosoma mansoni tyrosine kinase 0.0465 0.3027 0.3017
Schistosoma mansoni amine GPCR 0.0157 0.0764 0.075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0157 0.0764 0.075
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.012 0.0495 0.048
Schistosoma mansoni hypothetical protein 0.0157 0.0764 0.075
Echinococcus multilocularis c src tyrosine kinase 0.012 0.0495 0.0495
Schistosoma mansoni neuropeptide receptor 0.0157 0.0764 0.075
Echinococcus granulosus alpha 1A adrenergic receptor 0.0157 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0157 0.0764 0.0764
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0806 0.5527 1
Echinococcus multilocularis neuropeptide s receptor 0.0157 0.0764 0.0764

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 30 nM In vitro promotion of plasminogen activator secretion from F9 (murine teratocarcinoma) cells. ChEMBL. 8544175
AC50 (functional) = 30 nM In vitro promotion of plasminogen activator secretion from F9 (murine teratocarcinoma) cells. ChEMBL. 8544175
Ki (binding) = 17 nM Binding affinity to retinoic acid receptor beta using [3H]-CD 367 as radioligand ChEMBL. 8544175
Ki (binding) = 17 nM Binding affinity to retinoic acid receptor beta using [3H]-CD 367 as radioligand ChEMBL. 8544175
Ki (binding) = 29 nM Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand ChEMBL. 8544175
Ki (binding) = 29 nM Binding affinity to retinoic acid receptor (RAR) gamma using [3H]-CD 367 as radioligand ChEMBL. 8544175
Ki (binding) = 420 nM Binding affinity to retinoic acid receptor alpha using [3H]-CD 367 as radioligand ChEMBL. 8544175
Ki (binding) = 420 nM Binding affinity to retinoic acid receptor alpha using [3H]-CD 367 as radioligand ChEMBL. 8544175

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 8544175

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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