Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0148 | 0.5755 | 0.5134 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0226 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.5755 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0226 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0066 | 0.1278 | 0.1278 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0226 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0053 | 0.0573 | 0.0288 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0226 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0226 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0066 | 0.1278 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0108 | 0.3561 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0066 | 0.1278 | 0.368 |
Brugia malayi | thymidylate synthase | 0.0105 | 0.3421 | 1 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0226 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.5755 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.006 | 0.0968 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0066 | 0.1278 | 0.1361 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.5755 | 0.5755 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0066 | 0.1278 | 0.368 |
Mycobacterium tuberculosis | Hypothetical protein | 0.005 | 0.0419 | 0.039 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0066 | 0.1278 | 0.368 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0119 | 0.4163 | 0.3308 |
Echinococcus granulosus | thymidylate synthase | 0.0105 | 0.3421 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0119 | 0.4163 | 0.4145 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.5755 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0226 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0119 | 0.4163 | 0.4145 |
Brugia malayi | Probable DNA topoisomerase II | 0.0066 | 0.1278 | 0.368 |
Mycobacterium ulcerans | thymidylate synthase | 0.0105 | 0.3421 | 0.3401 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0066 | 0.1278 | 0.368 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0066 | 0.1278 | 0.368 |
Onchocerca volvulus | 0.0105 | 0.3421 | 1 | |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0053 | 0.0573 | 0.0288 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0066 | 0.1278 | 0.1609 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0119 | 0.4163 | 0.3308 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0105 | 0.3421 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0119 | 0.4163 | 0.4145 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0105 | 0.3421 | 0.9604 |
Loa Loa (eye worm) | thymidylate synthase | 0.0105 | 0.3421 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0119 | 0.4163 | 0.4145 |
Brugia malayi | hypothetical protein | 0.005 | 0.0419 | 0.1148 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0105 | 0.3421 | 0.3401 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0066 | 0.1278 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.5755 | 0.5134 |
Echinococcus multilocularis | thymidylate synthase | 0.0105 | 0.3421 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0066 | 0.1278 | 0.1609 |
Schistosoma mansoni | DNA topoisomerase II | 0.0066 | 0.1278 | 0.368 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0066 | 0.1278 | 0.1361 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | NA 0 uM | Antiasthmatic activity against the immunoglobulin E (IgE) antigen using the human basophil asthma model; I = Inactive at 48 microM | ChEMBL. | 1969485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.