Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0307 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0307 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0307 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0307 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0307 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0307 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0307 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0307 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0307 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0307 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0307 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0307 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0307 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0307 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0307 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0307 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 0.28 | Calculated partition coefficient (clogP) (Molgen) | ChEMBL. | 14584949 |
clogP | = 1.62 | Calculated partition coefficient (clogP) (HINT) | ChEMBL. | 14584949 |
EC50 (binding) | = 128 umol/L | Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | ChEMBL. | 17352460 |
EC50 (binding) | = 128 umol/L | Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay | ChEMBL. | 17352460 |
IC50 (functional) | = 117.69 uM | In vitro multi drug resistance (MDR) reversal inhibitory activity against CCRF-CEM/VCR-1000 cell line | ChEMBL. | 14584949 |
IC50 (functional) | = 117.69 uM | In vitro multi drug resistance (MDR) reversal inhibitory activity against CCRF-CEM/VCR-1000 cell line | ChEMBL. | 14584949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.