Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0025 | 0.014 | 0.0088 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0025 | 0.014 | 0.014 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0041 | 0.0531 | 0.0531 |
Brugia malayi | NADH-dependent xylose reductase | 0.0124 | 0.2557 | 0.2451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Giardia lamblia | Aldose reductase | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0378 | 0.0241 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0124 | 0.2557 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0531 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0427 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0378 | 0.0241 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0124 | 0.2557 | 0.2451 |
Trypanosoma cruzi | aldo-keto reductase | 0.0427 | 1 | 1 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0124 | 0.2557 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0303 | 0.6965 | 0.5922 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Brugia malayi | phosphatidylinositol 4-kinase, catalytic, alpha polypeptide | 0.0041 | 0.0531 | 0.0396 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2557 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.014 | 0.014 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0671 | 0.0538 |
Toxoplasma gondii | aldo-keto reductase | 0.0124 | 0.2557 | 0.2517 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0124 | 0.2557 | 0.2451 |
Schistosoma mansoni | potassium channel beta | 0.0124 | 0.2557 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0774 | 0.0774 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Mycobacterium ulcerans | oxidoreductase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0041 | 0.0531 | 0.0396 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0025 | 0.014 | 0.014 |
Echinococcus multilocularis | aldehyde reductase | 0.0303 | 0.6965 | 0.6922 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0041 | 0.0531 | 0.0531 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0427 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2557 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0124 | 0.2557 | 0.2451 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0671 | 0.0538 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0124 | 0.2557 | 0.2451 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0124 | 0.2557 | 0.2557 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0041 | 0.0531 | 0.0396 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0671 | 0.0671 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0041 | 0.0531 | 0.0396 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.014 | 0.014 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0124 | 0.2557 | 0.2517 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0303 | 0.6965 | 0.6922 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0671 | 0.0538 |
Trypanosoma brucei | prostaglandin f synthase | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0671 | 0.0538 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0396 |
Toxoplasma gondii | aldose reductase, putative | 0.0427 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0396 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0025 | 0.014 | 0.014 |
Loa Loa (eye worm) | oxidoreductase | 0.0427 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0124 | 0.2557 | 0.2451 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0427 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0025 | 0.014 | 0.014 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0124 | 0.2557 | 0.2557 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0671 | 0.0538 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0427 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0378 | 0.0378 |
Giardia lamblia | Aldose reductase | 0.0427 | 1 | 1 |
Onchocerca volvulus | 0.0427 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0124 | 0.2557 | 0.2451 |
Echinococcus multilocularis | aldo keto reductase | 0.0427 | 1 | 1 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0025 | 0.014 | 0.0088 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0774 | 0.0642 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0671 | 0.0538 |
Echinococcus granulosus | aldo keto reductase | 0.0427 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0427 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0041 | 0.0531 | 0.0531 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0124 | 0.2557 | 0.2517 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0427 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0025 | 0.014 | 0.014 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0124 | 0.2557 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0427 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0427 | 1 | 1 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0041 | 0.0531 | 0.0396 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0041 | 0.0531 | 0.0396 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0774 | 0.0774 |
Echinococcus granulosus | hypothetical protein | 0.0427 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0124 | 0.2557 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0774 | 0.0642 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0427 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CT50 (functional) | = 0.3 ug ml-1 | Cytotoxicity in rapidly proliferating CCRF-CEM cell lines after 72 hr exposure | ChEMBL. | 8960564 |
CT50 (functional) | = 0.3 ug ml-1 | Cytotoxicity in rapidly proliferating CCRF-CEM cell lines after 72 hr exposure | ChEMBL. | 8960564 |
IC50 (binding) | = 0.4 ng ml-1 | Inhibition of Phosphatidylinositol 3-kinase from bovine brain | ChEMBL. | 8960564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.